Absolute quantification and modulation of cytochrome P450 3A isoforms in cattle liver

• Published in: The veterinary journal (1997) Vol. 202; no. 1; pp. 106 - 111
• Main Authors: Zancanella, V., Giantin, M., Dacasto, M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2014
• Subjects: Absolute quantification; Animals; Aryl Hydrocarbon Hydroxylases - genetics; Aryl Hydrocarbon Hydroxylases - metabolism; Breed-differences; Cattle; Cattle - genetics; Cattle - metabolism; CYP3A; Gene expression; Gene Expression Regulation, Enzymologic - physiology; Isoenzymes - genetics; Isoenzymes - metabolism; Liver - enzymology; Phenobarbital; CYP3A; Breed-differences; Phenobarbital; Gene expression; Cattle; Absolute quantification

In humans and laboratory animals, knowledge about cytochrome P450 (CYP) regulation and function is detailed and very extensive. However, CYPs have still been incompletely characterized in veterinary species so far. In this study, mRNA levels of three CYP3A enzymes (CYP3A28, CYP3A38 and CYP3A48) were...