Hippocampal area CA2 activity supports social investigation following an acute social stress

• Published in: Molecular psychiatry Vol. 30; no. 6; pp. 2284 - 2296
• Main Authors: Radzicki, Daniel, McCann, Katharine E., Alexander, Georgia M., Dudek, Serena M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2025; Nature Publishing Group
• Subjects: 13/51; 14/19; 631/378; 631/443; 64/60; 9/74; Aggression; Aggression - physiology; Animals; Behavior, Animal - physiology; Behavioral Sciences; Biological Psychology; CA1 Region, Hippocampal - metabolism; CA2 Region, Hippocampal - metabolism; CA2 Region, Hippocampal - physiology; Cortex (cingulate); Defensive behavior; Electrophysiology; Hippocampus; Hippocampus - metabolism; Male; Medicine; Medicine & Public Health; Memory - physiology; Mice; Mice, Inbred C57BL; Neurons; Neurons - metabolism; Neurons - physiology; Neurosciences; Pharmacotherapy; Phenotypes; Psychiatry; Pyramidal Cells - metabolism; Pyramidal Cells - physiology; Recognition, Psychology - physiology; Social Behavior; Social Defeat; Social interactions; Stress, Psychological - metabolism; Stress, Psychological - physiopathology

Neuronal activity in the hippocampus is critical for many types of memory acquisition and retrieval and influences an animal’s response to stress. Moreover, the molecularly distinct principal neurons of hippocampal area CA2 are required for social recognition memory and aggression in mice. To interr...