C-phycocyanin transcriptionally regulates uPA mRNA through cAMP mediated PKA pathway in human fibroblast WI-38 cells

• Published in: Biochimica et biophysica acta Vol. 1760; no. 11; pp. 1624 - 1630
• Main Authors: Madhyastha, H.K., Radha, K.S., Sugiki, M., Omura, S., Maruyama, M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2006
• Subjects: C-phycocyanin; Cells, Cultured; Cyclic AMP - metabolism; Cyclic AMP-Dependent Protein Kinases - metabolism; Fibroblast; Fibroblasts - metabolism; Gene Expression Regulation; Humans; Phycocyanin - pharmacology; PKA pathway; Protein Biosynthesis; RNA, Messenger - metabolism; Signal Transduction; Spirulina fusiformis; Transcription, Genetic; uPA; Urokinase-Type Plasminogen Activator - genetics; Urokinase-Type Plasminogen Activator - metabolism; c-pc; DDA; CHX; DRB; PMA; PKA pathway; Spirulina fusiformis; uPA; dBcAMP; C-phycocyanin; Fibroblast

We have previously demonstrated the efficacy of c-phycocyanin in up-regulation of urokinase-type plasminogen activator (uPA) in bovine endothelial cell line. However, the mechanism of action and pathway elucidation in uPA regulation is unclear. In experiments reported here, we have investigated the...