Pluripotent Stem Cell-Engineered Cell Sheets Reassembled with Defined Cardiovascular Populations Ameliorate Reduction in Infarct Heart Function Through Cardiomyocyte-Mediated Neovascularization

• Published in: Stem cells (Dayton, Ohio) Vol. 30; no. 6; pp. 1196 - 1205
• Main Authors: Masumoto, Hidetoshi, Matsuo, Takehiko, Yamamizu, Kohei, Uosaki, Hideki, Narazaki, Genta, Katayama, Shiori, Marui, Akira, Shimizu, Tatsuya, Ikeda, Tadashi, Okano, Teruo, Sakata, Ryuzo, Yamashita, Jun K.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2012; Oxford University Press
• Subjects: Animals; Coronary Vessels - growth & development; Disease Models, Animal; Heart attacks; Male; Medical research; Mice; Myocardial infarction; Myocardial Infarction - pathology; Myocardial Infarction - surgery; Myocytes, Cardiac - cytology; Myocytes, Cardiac - physiology; Myocytes, Cardiac - transplantation; Neovascularization, Physiologic; Pluripotent stem cells; Pluripotent Stem Cells - cytology; Pluripotent Stem Cells - physiology; Pluripotent Stem Cells - transplantation; Prospective Studies; Rats; Rats, Nude; Stem Cell Transplantation - methods; Stem cells; Tissue engineering; Tissue Engineering - methods; Transplants & implants; Ventricular remodeling

Although stem cell therapy is a promising strategy for cardiac restoration, the heterogeneity of transplanted cells has been hampering the precise understanding of the cellular and molecular mechanisms. Previously, we established a cardiovascular cell differentiation system from mouse pluripotent st...