Ethnic Differences in Insulin Sensitivity, β-Cell Function, and Hepatic Extraction Between Japanese and Caucasians: A Minimal Model Analysis
Context:Ethnic differences have previously been reported for type 2 diabetes.Objective:We aimed at assessing the potential differences between Caucasian and Japanese subjects ranging from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) and to type 2 diabetes.Design:This was a cros...
Saved in:
| Published in | The journal of clinical endocrinology and metabolism Vol. 99; no. 11; pp. 4273 - 4280 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Bethesda, MD
Oxford University Press
01.11.2014
Copyright by The Endocrine Society Endocrine Society |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Context:Ethnic differences have previously been reported for type 2 diabetes.Objective:We aimed at assessing the potential differences between Caucasian and Japanese subjects ranging from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) and to type 2 diabetes.Design:This was a cross-sectional study with oral glucose tolerance tests to assess β-cell function, hepatic insulin extraction, and insulin sensitivity.Participants:Participants included 120 Japanese and 150 Caucasian subjects.Main Outcomes:Measures of β-cell function, hepatic extraction, and insulin sensitivity were assessed using C-peptide, glucose, and insulin minimal models.Results:Basal β-cell function (Φb) was lower in Japanese compared with Caucasians (P < .01). In subjects with IGT, estimates of the dynamic (Φd) and static (Φs) β-cell responsiveness were significantly lower in the Japanese compared with Caucasians (P < .05). In contrast, values of insulin action showed higher sensitivity in the Japanese IGT subjects. Hepatic extraction was similar in NGT and IGT groups but higher in Japanese type 2 diabetic subjects (P < .01). Despite differences in insulin sensitivity, β-cell function, and hepatic extraction, the disposition indices were similar between the 2 ethnic groups at all glucose tolerance states. Furthermore, the overall insulin sensitivity and β-cell responsiveness for all glucose tolerance states were similar in Japanese and Caucasians after accounting for differences in body mass index.Conclusion:Our study provides evidence for a similar ability of Japanese and Caucasians to compensate for increased insulin resistance. |
|---|---|
| AbstractList | Context:Ethnic differences have previously been reported for type 2 diabetes.Objective:We aimed at assessing the potential differences between Caucasian and Japanese subjects ranging from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) and to type 2 diabetes.Design:This was a cross-sectional study with oral glucose tolerance tests to assess β-cell function, hepatic insulin extraction, and insulin sensitivity.Participants:Participants included 120 Japanese and 150 Caucasian subjects.Main Outcomes:Measures of β-cell function, hepatic extraction, and insulin sensitivity were assessed using C-peptide, glucose, and insulin minimal models.Results:Basal β-cell function (Φb) was lower in Japanese compared with Caucasians (P < .01). In subjects with IGT, estimates of the dynamic (Φd) and static (Φs) β-cell responsiveness were significantly lower in the Japanese compared with Caucasians (P < .05). In contrast, values of insulin action showed higher sensitivity in the Japanese IGT subjects. Hepatic extraction was similar in NGT and IGT groups but higher in Japanese type 2 diabetic subjects (P < .01). Despite differences in insulin sensitivity, β-cell function, and hepatic extraction, the disposition indices were similar between the 2 ethnic groups at all glucose tolerance states. Furthermore, the overall insulin sensitivity and β-cell responsiveness for all glucose tolerance states were similar in Japanese and Caucasians after accounting for differences in body mass index.Conclusion:Our study provides evidence for a similar ability of Japanese and Caucasians to compensate for increased insulin resistance. CONTEXT:Ethnic differences have previously been reported for type 2 diabetes. OBJECTIVE:We aimed at assessing the potential differences between Caucasian and Japanese subjects ranging from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) and to type 2 diabetes. DESIGN:This was a cross-sectional study with oral glucose tolerance tests to assess β-cell function, hepatic insulin extraction, and insulin sensitivity. PARTICIPANTS:Participants included 120 Japanese and 150 Caucasian subjects. MAIN OUTCOMES:Measures of β-cell function, hepatic extraction, and insulin sensitivity were assessed using C-peptide, glucose, and insulin minimal models. RESULTS:Basal β-cell function (Φb) was lower in Japanese compared with Caucasians (P < .01). In subjects with IGT, estimates of the dynamic (Φd) and static (Φs) β-cell responsiveness were significantly lower in the Japanese compared with Caucasians (P < .05). In contrast, values of insulin action showed higher sensitivity in the Japanese IGT subjects. Hepatic extraction was similar in NGT and IGT groups but higher in Japanese type 2 diabetic subjects (P < .01). Despite differences in insulin sensitivity, β-cell function, and hepatic extraction, the disposition indices were similar between the 2 ethnic groups at all glucose tolerance states. Furthermore, the overall insulin sensitivity and β-cell responsiveness for all glucose tolerance states were similar in Japanese and Caucasians after accounting for differences in body mass index. CONCLUSION:Our study provides evidence for a similar ability of Japanese and Caucasians to compensate for increased insulin resistance. Ethnic differences have previously been reported for type 2 diabetes.CONTEXTEthnic differences have previously been reported for type 2 diabetes.We aimed at assessing the potential differences between Caucasian and Japanese subjects ranging from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) and to type 2 diabetes.OBJECTIVEWe aimed at assessing the potential differences between Caucasian and Japanese subjects ranging from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) and to type 2 diabetes.This was a cross-sectional study with oral glucose tolerance tests to assess β-cell function, hepatic insulin extraction, and insulin sensitivity.DESIGNThis was a cross-sectional study with oral glucose tolerance tests to assess β-cell function, hepatic insulin extraction, and insulin sensitivity.PARTICIPANTS included 120 Japanese and 150 Caucasian subjects.PARTICIPANTSPARTICIPANTS included 120 Japanese and 150 Caucasian subjects.Measures of β-cell function, hepatic extraction, and insulin sensitivity were assessed using C-peptide, glucose, and insulin minimal models.MAIN OUTCOMESMeasures of β-cell function, hepatic extraction, and insulin sensitivity were assessed using C-peptide, glucose, and insulin minimal models.Basal β-cell function (Φ(b)) was lower in Japanese compared with Caucasians (P < .01). In subjects with IGT, estimates of the dynamic (Φ(d)) and static (Φ(s)) β-cell responsiveness were significantly lower in the Japanese compared with Caucasians (P < .05). In contrast, values of insulin action showed higher sensitivity in the Japanese IGT subjects. Hepatic extraction was similar in NGT and IGT groups but higher in Japanese type 2 diabetic subjects (P < .01). Despite differences in insulin sensitivity, β-cell function, and hepatic extraction, the disposition indices were similar between the 2 ethnic groups at all glucose tolerance states. Furthermore, the overall insulin sensitivity and β-cell responsiveness for all glucose tolerance states were similar in Japanese and Caucasians after accounting for differences in body mass index.RESULTSBasal β-cell function (Φ(b)) was lower in Japanese compared with Caucasians (P < .01). In subjects with IGT, estimates of the dynamic (Φ(d)) and static (Φ(s)) β-cell responsiveness were significantly lower in the Japanese compared with Caucasians (P < .05). In contrast, values of insulin action showed higher sensitivity in the Japanese IGT subjects. Hepatic extraction was similar in NGT and IGT groups but higher in Japanese type 2 diabetic subjects (P < .01). Despite differences in insulin sensitivity, β-cell function, and hepatic extraction, the disposition indices were similar between the 2 ethnic groups at all glucose tolerance states. Furthermore, the overall insulin sensitivity and β-cell responsiveness for all glucose tolerance states were similar in Japanese and Caucasians after accounting for differences in body mass index.Our study provides evidence for a similar ability of Japanese and Caucasians to compensate for increased insulin resistance.CONCLUSIONOur study provides evidence for a similar ability of Japanese and Caucasians to compensate for increased insulin resistance. Ethnic differences have previously been reported for type 2 diabetes. We aimed at assessing the potential differences between Caucasian and Japanese subjects ranging from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) and to type 2 diabetes. This was a cross-sectional study with oral glucose tolerance tests to assess β-cell function, hepatic insulin extraction, and insulin sensitivity. PARTICIPANTS included 120 Japanese and 150 Caucasian subjects. Measures of β-cell function, hepatic extraction, and insulin sensitivity were assessed using C-peptide, glucose, and insulin minimal models. Basal β-cell function (Φ(b)) was lower in Japanese compared with Caucasians (P < .01). In subjects with IGT, estimates of the dynamic (Φ(d)) and static (Φ(s)) β-cell responsiveness were significantly lower in the Japanese compared with Caucasians (P < .05). In contrast, values of insulin action showed higher sensitivity in the Japanese IGT subjects. Hepatic extraction was similar in NGT and IGT groups but higher in Japanese type 2 diabetic subjects (P < .01). Despite differences in insulin sensitivity, β-cell function, and hepatic extraction, the disposition indices were similar between the 2 ethnic groups at all glucose tolerance states. Furthermore, the overall insulin sensitivity and β-cell responsiveness for all glucose tolerance states were similar in Japanese and Caucasians after accounting for differences in body mass index. Our study provides evidence for a similar ability of Japanese and Caucasians to compensate for increased insulin resistance. |
| Author | Dalla Man, Chiara Tornøe, Christoffer W. Ohsugi, Mitsuru Pedersen, Bente K. Pedersen, Maria Cobelli, Claudio Tanaka, Haruhiko Møller, Jonas B. Overgaard, Rune V. Ingwersen, Steen H. Kadowaki, Takashi Vasconcelos, Nina-Maria Ueki, Kohjiru Lynge, Jan |
| AuthorAffiliation | Novo Nordisk A/S (J.B.M., R.V.O., S.H.I., C.W.T., J.L., N.-M.V.), 2880 Bagsvaerd, Denmark; Department of Information Engineering (C.D.M., C.C.), Universita di Padova, 35131 Padova, Italy; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research (M.P., B.K.P.), Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark; and Department of Metabolic Diseases (H.T., M.O., K.U., T.K.), Graduate School of Medicine, University of Tokyo, 113-8654 Tokyo, Japan |
| AuthorAffiliation_xml | – name: Novo Nordisk A/S (J.B.M., R.V.O., S.H.I., C.W.T., J.L., N.-M.V.), 2880 Bagsvaerd, Denmark; Department of Information Engineering (C.D.M., C.C.), Universita di Padova, 35131 Padova, Italy; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research (M.P., B.K.P.), Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark; and Department of Metabolic Diseases (H.T., M.O., K.U., T.K.), Graduate School of Medicine, University of Tokyo, 113-8654 Tokyo, Japan |
| Author_xml | – sequence: 1 givenname: Jonas B. surname: Møller fullname: Møller, Jonas B. organization: 1Novo Nordisk A/S (J.B.M., R.V.O., S.H.I., C.W.T., J.L., N.-M.V.), 2880 Bagsvaerd, Denmark – sequence: 2 givenname: Chiara surname: Dalla Man fullname: Dalla Man, Chiara organization: 2Department of Information Engineering (C.D.M., C.C.), Universita di Padova, 35131 Padova, Italy – sequence: 3 givenname: Rune V. surname: Overgaard fullname: Overgaard, Rune V. organization: 1Novo Nordisk A/S (J.B.M., R.V.O., S.H.I., C.W.T., J.L., N.-M.V.), 2880 Bagsvaerd, Denmark – sequence: 4 givenname: Steen H. surname: Ingwersen fullname: Ingwersen, Steen H. email: SI@novonordisk.com organization: 1Novo Nordisk A/S (J.B.M., R.V.O., S.H.I., C.W.T., J.L., N.-M.V.), 2880 Bagsvaerd, Denmark – sequence: 5 givenname: Christoffer W. surname: Tornøe fullname: Tornøe, Christoffer W. organization: 1Novo Nordisk A/S (J.B.M., R.V.O., S.H.I., C.W.T., J.L., N.-M.V.), 2880 Bagsvaerd, Denmark – sequence: 6 givenname: Maria surname: Pedersen fullname: Pedersen, Maria organization: 3The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research (M.P., B.K.P.), Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 7 givenname: Haruhiko surname: Tanaka fullname: Tanaka, Haruhiko organization: 4Department of Metabolic Diseases (H.T., M.O., K.U., T.K.), Graduate School of Medicine, University of Tokyo, 113-8654 Tokyo, Japan – sequence: 8 givenname: Mitsuru surname: Ohsugi fullname: Ohsugi, Mitsuru organization: 4Department of Metabolic Diseases (H.T., M.O., K.U., T.K.), Graduate School of Medicine, University of Tokyo, 113-8654 Tokyo, Japan – sequence: 9 givenname: Kohjiru surname: Ueki fullname: Ueki, Kohjiru organization: 4Department of Metabolic Diseases (H.T., M.O., K.U., T.K.), Graduate School of Medicine, University of Tokyo, 113-8654 Tokyo, Japan – sequence: 10 givenname: Jan surname: Lynge fullname: Lynge, Jan organization: 1Novo Nordisk A/S (J.B.M., R.V.O., S.H.I., C.W.T., J.L., N.-M.V.), 2880 Bagsvaerd, Denmark – sequence: 11 givenname: Nina-Maria surname: Vasconcelos fullname: Vasconcelos, Nina-Maria organization: 1Novo Nordisk A/S (J.B.M., R.V.O., S.H.I., C.W.T., J.L., N.-M.V.), 2880 Bagsvaerd, Denmark – sequence: 12 givenname: Bente K. surname: Pedersen fullname: Pedersen, Bente K. organization: 3The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research (M.P., B.K.P.), Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 13 givenname: Takashi surname: Kadowaki fullname: Kadowaki, Takashi organization: 4Department of Metabolic Diseases (H.T., M.O., K.U., T.K.), Graduate School of Medicine, University of Tokyo, 113-8654 Tokyo, Japan – sequence: 14 givenname: Claudio surname: Cobelli fullname: Cobelli, Claudio organization: 2Department of Information Engineering (C.D.M., C.C.), Universita di Padova, 35131 Padova, Italy |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28943486$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/25119313$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1ks1uEzEQx1eoiKaFG2dkCSE4ZIu_dr3LLYSUFrXiAEjcLK93rDg43nTtbZqH4GV4EJ4J56NCqlRfRh79_uOZ__gkO_Kdhyx7SfAZoQS_X-gzignPiaD8STYiNS9yQWpxlI0wpiSvBf15nJ2EsMAJ4wV7lh3TgpCaETbKfs_i3FuNPlljoAevISDr0aUPg0vxG_hgo721cTNGf__kU3AOnQ9eR9v5MVK-RRewUjFVmN3FXu3y6CPENYBHX9RKeQiw46Zq0CpY5cMHNEHX1tulcui6a8GhiVduE2x4nj01ygV4cYin2Y_z2ffpRX719fPldHKVa07LMjemaSqGhakxo8pobngliMLMCNyaqqmM4dpQw-uq0aXiDW6AAm8ZQCFaRdhp9m5fd9V3NwOEKJc26DRbarcbgiQlpbgoeSES-voBuuiGPvUbJCMl56JMXKJeHaihWUIrV32art_Ie6MT8OYAqKCVM73y2ob_XFVzxqsycXTP6b4LoQcjtY1q62py1zpJsNxuXS603G5dbreeROMHovu6j-B8j687F6EPv9ywhl7OQbk4lzgdXooq3woISbd8l0myt3tZN6wee2D3C9k_fe3Jnw |
| CODEN | JCEMAZ |
| CitedBy_id | crossref_primary_10_1007_s12325_022_02121_5 crossref_primary_10_2337_dc21_1722 crossref_primary_10_1186_s13098_018_0376_8 crossref_primary_10_1155_2022_7764963 crossref_primary_10_1007_s12325_022_02311_1 crossref_primary_10_1111_dom_15729 crossref_primary_10_1016_j_metabol_2021_154957 crossref_primary_10_1111_jdi_13789 crossref_primary_10_1111_dom_14036 crossref_primary_10_1111_jdi_13106 crossref_primary_10_4093_dmj_2018_42_2_137 crossref_primary_10_1111_jdi_12895 crossref_primary_10_1007_s13300_021_01196_7 crossref_primary_10_1016_j_jdiacomp_2016_10_008 crossref_primary_10_1111_jdi_12490 crossref_primary_10_1186_s12902_023_01300_x crossref_primary_10_1371_journal_pone_0189115 crossref_primary_10_1111_jdi_14271 crossref_primary_10_1016_j_soard_2018_03_016 crossref_primary_10_1007_s13300_017_0328_6 crossref_primary_10_1210_clinem_dgab545 crossref_primary_10_1111_dom_13757 crossref_primary_10_1016_j_diabres_2017_11_025 crossref_primary_10_1109_TBME_2024_3352153 crossref_primary_10_1177_0004563216675646 crossref_primary_10_1210_js_2019_00167 crossref_primary_10_1007_s11154_024_09914_9 crossref_primary_10_1016_j_diabres_2017_05_023 crossref_primary_10_1016_S2213_8587_15_00389_7 crossref_primary_10_1111_dom_14642 crossref_primary_10_4093_dmj_2018_42_2_128 crossref_primary_10_1055_a_1493_2948 crossref_primary_10_1111_1753_0407_12484 crossref_primary_10_1007_s13340_022_00592_z crossref_primary_10_2337_dc19_2452 crossref_primary_10_1038_s41598_024_67513_9 crossref_primary_10_1038_s41586_024_07019_6 crossref_primary_10_1007_s11892_015_0602_9 crossref_primary_10_1177_19322968231223936 crossref_primary_10_1371_journal_pone_0312439 crossref_primary_10_1371_journal_pone_0211067 crossref_primary_10_1080_09513590_2016_1177009 crossref_primary_10_1155_2016_7836823 crossref_primary_10_1111_dom_14537 crossref_primary_10_1210_clinem_dgaa524 crossref_primary_10_3389_fendo_2024_1301352 crossref_primary_10_1016_S2213_8587_19_30425_5 crossref_primary_10_1097_CM9_0000000000000012 crossref_primary_10_1111_cts_12732 crossref_primary_10_1177_19322968211015268 crossref_primary_10_1016_j_bone_2019_01_005 crossref_primary_10_1111_jdi_13323 crossref_primary_10_1111_dom_14139 crossref_primary_10_1111_jdi_13563 crossref_primary_10_1111_jdi_13564 crossref_primary_10_4093_dmj_2023_0200 crossref_primary_10_1111_jdi_12550 crossref_primary_10_3390_jcdd10040176 crossref_primary_10_4093_dmj_2016_40_4_318 crossref_primary_10_1186_s12889_022_14555_1 crossref_primary_10_33590_emjdiabet_10312637 crossref_primary_10_1111_dom_14095 crossref_primary_10_1183_13993003_01700_2019 crossref_primary_10_1007_s13369_021_05945_5 crossref_primary_10_1186_s12933_017_0565_z crossref_primary_10_1007_s40618_022_01932_1 crossref_primary_10_1186_s13098_016_0131_y crossref_primary_10_1371_journal_pone_0234132 crossref_primary_10_1111_dom_15716 crossref_primary_10_1146_annurev_med_050219_034524 crossref_primary_10_1111_dom_12844 crossref_primary_10_1088_1742_6596_1805_1_012031 crossref_primary_10_1161_CIR_0000000000001145 crossref_primary_10_1016_j_ypmed_2016_07_026 crossref_primary_10_1080_03007995_2020_1760228 crossref_primary_10_1056_EVIDoa2100052 crossref_primary_10_1161_CIR_0000000000000580 crossref_primary_10_3389_fendo_2021_780557 crossref_primary_10_1007_s00394_015_1122_8 crossref_primary_10_1016_j_bone_2021_115912 crossref_primary_10_4093_dmj_2016_40_4_308 crossref_primary_10_1038_s41598_024_63678_5 crossref_primary_10_1080_14656566_2020_1776262 crossref_primary_10_1016_j_diabres_2020_108647 crossref_primary_10_1507_endocrj_EJ22_0330 |
| ContentType | Journal Article |
| Copyright | Copyright © 2014 by the Endocrine Society 2014 Copyright © 2014 by The Endocrine Society 2015 INIST-CNRS Copyright © 2014 by the Endocrine Society |
| Copyright_xml | – notice: Copyright © 2014 by the Endocrine Society 2014 – notice: Copyright © 2014 by The Endocrine Society – notice: 2015 INIST-CNRS – notice: Copyright © 2014 by the Endocrine Society |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7QP 7T5 7TM H94 K9. 7X8 |
| DOI | 10.1210/jc.2014-1724 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Calcium & Calcified Tissue Abstracts Immunology Abstracts Nucleic Acids Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts Calcium & Calcified Tissue Abstracts Nucleic Acids Abstracts MEDLINE - Academic |
| DatabaseTitleList | AIDS and Cancer Research Abstracts MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1945-7197 |
| EndPage | 4280 |
| ExternalDocumentID | 25119313 28943486 10_1210_jc_2014_1724 00004678-201411000-00046 10.1210/jc.2014-1724 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Comparative Study |
| GeographicLocations | Asia Japan |
| GeographicLocations_xml | – name: Japan |
| GroupedDBID | --- -~X .55 .XZ 08P 0R~ 18M 1TH 29K 2WC 34G 354 39C 4.4 48X 53G 5GY 5RS 5YH 8F7 AABZA AACZT AAIMJ AAPQZ AAPXW AARHZ AAUAY AAVAP AAWTL ABBLC ABDFA ABEJV ABGNP ABJNI ABLJU ABMNT ABNHQ ABOCM ABPMR ABPPZ ABPQP ABPTD ABQNK ABVGC ABWST ABXVV ACGFO ACGFS ACPRK ACUTJ ACYHN ADBBV ADGKP ADGZP ADHKW ADQBN ADRTK ADVEK AELWJ AEMDU AENEX AENZO AETBJ AEWNT AFCHL AFFZL AFGWE AFOFC AFRAH AFXAL AGINJ AGKRT AGQXC AGUTN AHMBA AHMMS AJEEA ALMA_UNASSIGNED_HOLDINGS APIBT ARIXL ASPBG ATGXG AVWKF AZFZN BAWUL BAYMD BCRHZ BEYMZ BSWAC BTRTY C45 CDBKE CS3 D-I DAKXR DIK E3Z EBS EJD EMOBN ENERS F5P FECEO FHSFR FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 HZ~ H~9 KBUDW KOP KQ8 KSI KSN L7B M5~ MHKGH MJL N9A NLBLG NOMLY NOYVH NVLIB O9- OAUYM OBH OCB ODMLO OFXIZ OGEVE OHH OJZSN OK1 OPAEJ OVD OVIDX P2P P6G REU ROX ROZ TEORI TJX TLC TR2 TWZ VVN W8F WOQ X7M YBU YFH YHG YOC YSK ZY1 ~02 ~H1 .GJ 3O- 7X7 88E 8FI 8FJ AAJQQ AAKAS AAPGJ AAQQT AAUQX AAWDT AAYJJ ABDPE ABUWG ABXZS ACFRR ACVCV ACZBC ADMTO ADNBA ADZCM AEMQT AEOTA AERZD AFFNX AFFQV AFKRA AFYAG AGMDO AGORE AHGBF AI. AJBYB AJDVS ALXQX APJGH AQDSO AQKUS AVNTJ BENPR BPHCQ BVXVI CCPQU EIHJH FEDTE FYUFA HMCUK HVGLF IAO IHR INH ITC J5H M1P MBLQV N4W NU- OBFPC PHGZM PHGZT PQQKQ PROAC PSQYO TMA UKHRP VH1 WHG X52 ZGI ZXP AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7QP 7T5 7TM H94 K9. 7X8 |
| ID | FETCH-LOGICAL-c4266-ffbb8307f9032afc4f4871a03f70df8b8ff4cf2f498bc6a4b0be2e4d3ee57da13 |
| ISSN | 0021-972X 1945-7197 |
| IngestDate | Wed Jul 30 10:50:39 EDT 2025 Mon Jun 30 12:41:43 EDT 2025 Thu Apr 03 07:04:26 EDT 2025 Wed Apr 02 07:18:30 EDT 2025 Tue Jul 01 01:10:32 EDT 2025 Thu Apr 24 23:05:48 EDT 2025 Fri May 16 03:42:27 EDT 2025 Fri Feb 07 10:35:26 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Keywords | Obesity Pancreatic hormone Cell function Nutrition Digestive system Insulin sensitivity Liver Nutrition disorder Metabolic diseases Insulin Japanese Ethnic group Extraction Models β Cell Caucasoid Endocrinology Nutritional status Comparative study |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c4266-ffbb8307f9032afc4f4871a03f70df8b8ff4cf2f498bc6a4b0be2e4d3ee57da13 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 |
| PMID | 25119313 |
| PQID | 3164476564 |
| PQPubID | 2046206 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_1622056457 proquest_journals_3164476564 pubmed_primary_25119313 pascalfrancis_primary_28943486 crossref_citationtrail_10_1210_jc_2014_1724 crossref_primary_10_1210_jc_2014_1724 wolterskluwer_health_00004678-201411000-00046 oup_primary_10_1210_jc_2014-1724 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2014-November |
| PublicationDateYYYYMMDD | 2014-11-01 |
| PublicationDate_xml | – month: 11 year: 2014 text: 2014-November |
| PublicationDecade | 2010 |
| PublicationPlace | Bethesda, MD |
| PublicationPlace_xml | – name: Bethesda, MD – name: United States – name: Washington |
| PublicationTitle | The journal of clinical endocrinology and metabolism |
| PublicationTitleAlternate | J Clin Endocrinol Metab |
| PublicationYear | 2014 |
| Publisher | Oxford University Press Copyright by The Endocrine Society Endocrine Society |
| Publisher_xml | – name: Oxford University Press – name: Copyright by The Endocrine Society – name: Endocrine Society |
| SSID | ssj0014453 |
| Score | 2.447934 |
| Snippet | Context:Ethnic differences have previously been reported for type 2 diabetes.Objective:We aimed at assessing the potential differences between Caucasian and... CONTEXT:Ethnic differences have previously been reported for type 2 diabetes. OBJECTIVE:We aimed at assessing the potential differences between Caucasian and... Ethnic differences have previously been reported for type 2 diabetes. We aimed at assessing the potential differences between Caucasian and Japanese subjects... Ethnic differences have previously been reported for type 2 diabetes.CONTEXTEthnic differences have previously been reported for type 2 diabetes.We aimed at... |
| SourceID | proquest pubmed pascalfrancis crossref wolterskluwer oup |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 4273 |
| SubjectTerms | Adult Aged Asian Continental Ancestry Group Beta cells Biological and medical sciences Blood Glucose Body mass index Cell culture Cross-Sectional Studies Cultural differences Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - physiopathology Endocrinopathies European Continental Ancestry Group Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Glucose Glucose Intolerance - blood Glucose Intolerance - ethnology Glucose Intolerance - physiopathology Glucose tolerance Glucose Tolerance Test Humans Insulin - blood Insulin resistance Insulin Resistance - ethnology Insulin-Secreting Cells - physiology Japan Liver Liver - physiopathology Male Medical sciences Middle Aged Minority & ethnic groups Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology White people |
| Title | Ethnic Differences in Insulin Sensitivity, β-Cell Function, and Hepatic Extraction Between Japanese and Caucasians: A Minimal Model Analysis |
| URI | https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00004678-201411000-00046 https://www.ncbi.nlm.nih.gov/pubmed/25119313 https://www.proquest.com/docview/3164476564 https://www.proquest.com/docview/1622056457 |
| Volume | 99 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3bbtNAEF2FIiEkhLiWQKkWiTxRI182vvDWpInS0hSJJlLerPV6tw20TpQ4AvEP_AwfwpfwEcx4144jpQh4sSJnYm08Z3dmdmfmEPIaD9tUoHxLeH5qMVfBlHI5ziufqSBl0k2xUHh45g_G7GTSnjQav2pZS6s8eSu-ba0r-R-twj3QK1bJ_oNmq4fCDfgM-oUraBiuf6XjXn6J_DVHhuREJ1fh-X-RXn6OuemaHAJfZKvba3Vcq4ubdX2wZkVWh8ndHMh50bm19zVfGPLwjkngOgFriiyVhVyXI0faFJ3voqJ9OM2m11jdi3w6VYOTusOLMKx1p6gKMWWWzmDBytYtoK5lDoC8KlsaIgjwFL8TlsWKuNG_XLNEdy-nfMEBtgBkzOKptotBjRec65T9j9gVpcrjPc4ukBNOr7TnOf69QX3bw2Gm_q8KkreXU9aXesw9CQqudjB0enWPWNsKHJ0QXC7_mp-phLlTW8yZq1lWjGMAgZq91ehA1IxGBxti4jgDXRS-2dv77EPcH5-exqPeZHSL3HYhqEG-jaPj99WZF2OmZ6oZuCnTwBqr-rM3HChdlHlvzpegOqWpWLbFSiDzZYbpF8vPRfVFzYcaPSD3TfBDDzWSH5KGzB6RO0OT3vGYfNeApjVA02lGDaBpDdAH9OePAsq0hPIBBRBRA2S6BjI1QKYlkAu5NZDf0UNqYEwLGNMSxk_IuN8bdQeW4QuxBPqZllJJEoLNUpHtuVwJpiAad7jtqcBOVZiESjGhXMWiMBE-Z4mdSFey1JOyHaTc8Z6SnWyWyWeEqiAJhJOkPPJ9FiUC9GGrUERg8YQQ0m6SN6USYmGa6SOny1WMQTWoLP4kYlRZjCprklYlPddNZG6Qo6DPm0QsLbK_oexK2EUiBRb6TbJXaj8203sZe7DysgBCN_j9q-prMCR4OgjvfrZaxo6PNfc-awdNsqtRs344Zht4jtck1gaMYl2sHRc7DeD2WjhObEKpu1X4z_88mBfk7npq75GdfLGSL8HHz5P9Ymr8BhRh_R0 |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Ethnic+Differences+in+Insulin+Sensitivity%2C+%CE%B2-Cell+Function%2C+and+Hepatic+Extraction+Between+Japanese+and+Caucasians%3A+A+Minimal+Model+Analysis&rft.jtitle=The+journal+of+clinical+endocrinology+and+metabolism&rft.au=M%C3%B8ller%2C+Jonas+B&rft.au=Chiara+Dalla+Man&rft.au=Overgaard%2C+Rune+V&rft.au=Ingwersen%2C+Steen+H&rft.date=2014-11-01&rft.pub=Oxford+University+Press&rft.issn=0021-972X&rft.eissn=1945-7197&rft.volume=99&rft.issue=11&rft.spage=4273&rft.epage=4280&rft_id=info:doi/10.1210%2Fjc.2014-1724&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-972X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-972X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-972X&client=summon |