A Phase I/IIa Trial of Intravenous Immunoglobulin Following Portoenterostomy in Biliary Atresia

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 68; no. 4; pp. 495 - 501
• Main Authors: Mack, Cara L., Spino, Cathie, Alonso, Estella M., Bezerra, Jorge A., Moore, Jeffrey, Goodhue, Catherine, Ng, Vicky L., Karpen, Saul J., Venkat, Veena, Loomes, Kathleen M., Wang, Kasper, Sherker, Averell H., Magee, John C., Sokol, Ronald J.
• Format: Journal Article
• Language: English
• Published: United States by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology 01.04.2019
• Subjects: adverse events; immunomodulation; liver transplantation; neonatal cholestasis

ABSTRACT Objectives: Biliary atresia (BA) is a progressive neonatal fibroinflammatory cholangiopathy. We hypothesized that intravenous immunoglobulin (IVIg) would be safe, feasible, acceptable, and efficacious for the treatment of BA. The primary objective of this study was to establish the feasibil...