Genome‐wide Association Study and Meta‐analysis on Alcohol‐Associated Liver Cirrhosis Identifies Genetic Risk Factors

• Published in: Hepatology (Baltimore, Md.) Vol. 73; no. 5; pp. 1920 - 1931
• Main Authors: Schwantes‐An, Tae‐Hwi, Darlay, Rebecca, Mathurin, Philippe, Masson, Steven, Liangpunsakul, Suthat, Mueller, Sebastian, Aithal, Guruprasad P., Eyer, Florian, Gleeson, Dermot, Thompson, Andrew, Muellhaupt, Beat, Stickel, Felix, Soyka, Michael, Goldman, David, Liang, Tiebing, Lumeng, Lawrence, Pirmohamed, Munir, Nalpas, Bertrand, Jacquet, Jean‐Marc, Moirand, Romain, Nahon, Pierre, Naveau, Sylvie, Perney, Pascal, Botwin, Greg, Haber, Paul S., Seitz, Helmut K., Day, Christopher P., Foroud, Tatiana M., Daly, Ann K., Cordell, Heather J., Whitfield, John B., Morgan, Timothy R., Seth, Devanshi
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.05.2021
• Subjects: Alcohol; Alcohol use; Alleles; Biobanks; Body mass index; Cirrhosis; Databases, Genetic; Diabetes mellitus; Drinking behavior; Female; Fetal alcohol syndrome; Genetic diversity; Genetic Predisposition to Disease - genetics; Genome-wide association studies; Genome-Wide Association Study; Genomes; Hepatocytes; Hepatology; Humans; Liver cirrhosis; Liver Cirrhosis, Alcoholic - genetics; Liver diseases; Male; Meta-analysis; Middle Aged; Risk Factors; United Kingdom > UK

Background and Aims Only a minority of heavy drinkers progress to alcohol‐associated cirrhosis (ALC). The aim of this study was to identify common genetic variants that underlie risk for ALC. Approach and Results We analyzed data from 1,128 subjects of European ancestry with ALC and 614 heavy‐drinki...