Involvement of 5-hydroxytryptamine and prostaglandin E2 in the intestinal secretory action of Escherichia coli heat-stable enterotoxin B

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Published inInfection and Immunity Vol. 63; no. 3; pp. 745 - 750
Main Authors HARVILLE, B. A, DREYFUS, L. A
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.03.1995
Subjects
Animals
Bacterial Toxins - pharmacology
Bacteriology
Biological and medical sciences
Dinoprostone - metabolism
Dinoprostone - pharmacology
Dose-Response Relationship, Drug
Enterotoxins - pharmacology
Escherichia coli - pathogenicity
Escherichia coli Proteins
Female
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Indomethacin - pharmacology
Intestines - drug effects
Intestines - metabolism
Intestines - microbiology
Ketanserin - pharmacology
Microbiology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Rats
Rats, Sprague-Dawley
Serotonin - metabolism
Serotonin - pharmacology
Water-Electrolyte Balance - drug effects
Animal model
Rat
Secretion
Arachidonic acid derivatives
Escherichia coli
Rodentia
Gut
Prostaglandin E2
Environmental factor
Host agent relation
Vertebrata
Mammalia
Medium effect
Enterotoxin
Bacteria
Enterobacteriaceae
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AbstractList The intestinal secretory action of Escherichia coli heat-stable enterotoxin B (STb) is poorly defined. Previous work indicates that STb causes loss of intestinal fluid and electrolytes by a mechanism independent of elevated levels of cyclic nucleotides, the hallmark of other E. coli cytotonic enterotoxins. In the work described in this report, we observed that treatment of ligated rat intestinal loops with purified STb of E. coli resulted in a dose-dependent rise in intestinal secretion concomitant with dose-related increases in levels of serotonin (5-hydroxytryptamine [5-HT]) and prostaglandin E2 (PGE2). Treatment of rats with the 5-HT2 receptor antagonist ketanserin prior to STb challenge resulted in significant (P < 0.05) reduction in intestinal secretion. Blockage of 5-HT2 receptors with ketanserin also reduced (P < 0.05) the level of PGE2 observed following STb treatment, indicating that at least a portion of the PGE2 was formed in response to 5-HT2 receptor stimulation. In a similar fashion, indomethacin, an inhibitor of cyclooxygenase activity, significantly reduced the level of secretion (P < 0.05) observed following STb treatment yet had no effect on 5-HT levels. Treatment of rats with both ketanserin and indomethacin further reduced STb-mediated secretion to a level not attained by either drug alone. Taken together, our data suggest that secretion due to STb involves both 5-HT and PGE2 as intestinal secretagogues. Furthermore, PGE2 formation appears to arise through both 5-HT-dependent and 5-HT-independent pathways.
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Author L A Dreyfus
B A Harville
AuthorAffiliation Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri-Kansas City 64110
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Issue 3
Keywords Animal model
Rat
Secretion
Arachidonic acid derivatives
Escherichia coli
Rodentia
Gut
Prostaglandin E2
Environmental factor
Host agent relation
Vertebrata
Mammalia
Medium effect
Enterotoxin
Bacteria
Enterobacteriaceae
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PublicationTitle Infection and Immunity
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The intestinal secretory action of Escherichia coli heat-stable enterotoxin B (STb) is poorly defined. Previous work indicates that STb causes loss of...
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SubjectTerms Animals
Bacterial Toxins - pharmacology
Bacteriology
Biological and medical sciences
Dinoprostone - metabolism
Dinoprostone - pharmacology
Dose-Response Relationship, Drug
Enterotoxins - pharmacology
Escherichia coli - pathogenicity
Escherichia coli Proteins
Female
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Indomethacin - pharmacology
Intestines - drug effects
Intestines - metabolism
Intestines - microbiology
Ketanserin - pharmacology
Microbiology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Rats
Rats, Sprague-Dawley
Serotonin - metabolism
Serotonin - pharmacology
Water-Electrolyte Balance - drug effects
Title Involvement of 5-hydroxytryptamine and prostaglandin E2 in the intestinal secretory action of Escherichia coli heat-stable enterotoxin B
URI http://iai.asm.org/content/63/3/745.abstract
https://www.ncbi.nlm.nih.gov/pubmed/7868242
https://pubmed.ncbi.nlm.nih.gov/PMC173065
Volume 63
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