A second look at efficacy criteria for onychomycosis: clinical and mycological cure

• Published in: British journal of dermatology (1951) Vol. 170; no. 1; pp. 182 - 187
• Main Authors: Ghannoum, M., Isham, N., Catalano, V.
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell Publishing Ltd 01.01.2014; Wiley-Blackwell
• Subjects: Administration, Topical; Antifungal Agents - administration & dosage; Biological and medical sciences; Dermatology; Female; Human mycoses; Humans; Infectious diseases; Male; Medical sciences; Multicenter Studies as Topic; Mycoses; Mycoses of the skin; Onychomycosis - drug therapy; Randomized Controlled Trials as Topic; Treatment Outcome; Infection; Skin disease; Mycosis; Criterion; Dermatology; Cure; Nail disease; Onychomycosis

Summary Background Approval of topical onychomycosis drugs by regulatory agencies may be negatively impacted by an overly stringent definition of complete cure, which includes nail clearing plus mycological cure. Objectives In this position paper, we discuss interpretation of mycological outcome and...