Thrombocytopenia impairs host defense during murine Streptococcus pneumoniae pneumonia

• Published in: Critical care medicine Vol. 43; no. 3; p. e75
• Main Authors: van den Boogaard, Florry E, Schouten, Marcel, de Stoppelaar, Sacha F, Roelofs, Joris J T H, Brands, Xanthe, Schultz, Marcus J, van't Veer, Cornelis, van der Poll, Tom
• Format: Journal Article
• Language: English
• Published: United States 01.03.2015
• Subjects: Animals; Antithrombin III - metabolism; Cytokines - metabolism; Disease Models, Animal; Mice; Peptide Hydrolases - metabolism; Pneumonia, Pneumococcal - epidemiology; Pneumonia, Pneumococcal - immunology; Pneumonia, Pneumococcal - pathology; Purinergic P2Y Receptor Antagonists - pharmacology; Streptococcus pneumoniae; Thrombocytopenia - epidemiology; Thrombocytopenia - immunology; Thrombocytopenia - pathology; Ticlopidine - analogs & derivatives; Ticlopidine - pharmacology

Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia. In patients, thrombocytopenia is correlated with an adverse outcome of pneumonia. Platelets can modulate the host response to infection in several ways, that is, by facilitating clot formation, production...