Cherry leaf decoction inhibits NMDAR expression and thereby ameliorates CUMS- induced depression-like behaviors through downregulation of α2δ-1

• Published in: Heliyon Vol. 9; no. 11; p. e21743
• Main Authors: Jiang, Chuan, Wang, Chaonan, Qu, Weizhong, Wang, Yuanyuan, Wang, Hua, Wei, Xin, Wang, Mingyan, He, Qianqian, Wang, Yihan, Yuan, Lirong, Gao, Yonggang
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.11.2023; Elsevier
• Subjects: Behavioral tests; CLD; Depression; HPA; NMDAR; α2δ-1; HPA; Depression; NMDAR; Behavioral tests; CLD; α2δ-1

Depression is a complex and prevalent mental illness. Cherry leaf is a traditional Chinese herbal medicine, which has confirmed to exert a certain antidepressant effect, but its potential neural regulation mechanism is not clear. This paper aims to investigate the improved action of cherry leaf deco...