Rapid and accurate stability-indicating assay for nitroglycerin

A rapid high-pressure liquid chromatographic method for determining the nitroglycerin concentration in liquid dosage forms and intravenous admixture solutions is presented. A coefficient of variation of less than 1.8% was achieved over the concentration range most commonly encountered (50-500 microg...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 68; no. 4; p. 481
Main Authors Baaske, D M, Carter, J E, Amann, A H
Format Journal Article
LanguageEnglish
Published United States 01.04.1979
Subjects
Chromatography, High Pressure Liquid
Drug Combinations
Drug Stability
Injections, Intravenous
Methods
Nitroglycerin - analysis
Solutions - analysis
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Summary:A rapid high-pressure liquid chromatographic method for determining the nitroglycerin concentration in liquid dosage forms and intravenous admixture solutions is presented. A coefficient of variation of less than 1.8% was achieved over the concentration range most commonly encountered (50-500 microgram/ml). A variable wavelength detector (lambda = 218 nm) and a micro-alkyl phenyl column were employed. The mobile phase was acetonitrile-tetrahydrofuran-water (26:10:64). Total analysis time was 12 min.
ISSN:0022-3549
DOI:10.1002/jps.2600680423