The Ets transcription factor ESE‐1 mediates induction of the COX‐2 gene by LPS in monocytes
Cyclooxygenase‐2 (COX‐2) is a key enzyme in the production of prostaglandins that are major inflammatory agents. COX‐2 production is triggered by exposure to various cytokines and to bacterial endotoxins. We present here a novel role for the Ets transcription factor ESE‐1 in regulating the COX‐2 gen...
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Published in | The FEBS journal Vol. 272; no. 7; pp. 1676 - 1687 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Oxford, UK
Blackwell Science Ltd
01.04.2005
Blackwell Publishing Ltd |
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Abstract | Cyclooxygenase‐2 (COX‐2) is a key enzyme in the production of prostaglandins that are major inflammatory agents. COX‐2 production is triggered by exposure to various cytokines and to bacterial endotoxins. We present here a novel role for the Ets transcription factor ESE‐1 in regulating the COX‐2 gene in response to endotoxin and other pro‐inflammatory stimuli. We report that the induction of COX‐2 expression by lipopolysaccharide (LPS) and pro‐inflammatory cytokines correlates with ESE‐1 induction in monocyte/macrophages. ESE‐1, in turn, binds to several E26 transformation specific (Ets) sites on the COX‐2 promoter. In vitro analysis demonstrates that ESE‐1 binds to and activates the COX‐2 promoter to levels comparable to LPS‐mediated induction. Moreover, we provide results showing that the induction of COX‐2 by LPS may require ESE‐1, as the mutation of the Ets sites in the COX‐2 promoter or overexpression of a dominant‐negative form of ESE‐1 inhibits LPS‐mediated COX‐2 induction. The effect of ESE‐1 on the COX‐2 promoter is further enhanced by cooperation with other transcription factors such as nuclear factor‐κB and nuclear factor of activated T cells. Neutralization of COX‐2 is the goal of many anti‐inflammatory drugs. As an activator of COX‐2 induction, ESE‐1 may become a target for such therapeutics as well. Together with our previous reports of the role of ESE‐1 as an inducer of nitric oxide synthase in endothelial cells and as a mediator of pro‐inflammatory cytokines in vascular and connective tissue cells, these results establish ESE‐1 as an important player in the regulation of inflammation. |
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AbstractList | Cyclooxygenase‐2 (COX‐2) is a key enzyme in the production of prostaglandins that are major inflammatory agents. COX‐2 production is triggered by exposure to various cytokines and to bacterial endotoxins. We present here a novel role for the Ets transcription factor ESE‐1 in regulating the COX‐2 gene in response to endotoxin and other pro‐inflammatory stimuli. We report that the induction of COX‐2 expression by lipopolysaccharide (LPS) and pro‐inflammatory cytokines correlates with ESE‐1 induction in monocyte/macrophages. ESE‐1, in turn, binds to several E26 transformation specific (Ets) sites on the COX‐2 promoter. In vitro analysis demonstrates that ESE‐1 binds to and activates the COX‐2 promoter to levels comparable to LPS‐mediated induction. Moreover, we provide results showing that the induction of COX‐2 by LPS may require ESE‐1, as the mutation of the Ets sites in the COX‐2 promoter or overexpression of a dominant‐negative form of ESE‐1 inhibits LPS‐mediated COX‐2 induction. The effect of ESE‐1 on the COX‐2 promoter is further enhanced by cooperation with other transcription factors such as nuclear factor‐κB and nuclear factor of activated T cells. Neutralization of COX‐2 is the goal of many anti‐inflammatory drugs. As an activator of COX‐2 induction, ESE‐1 may become a target for such therapeutics as well. Together with our previous reports of the role of ESE‐1 as an inducer of nitric oxide synthase in endothelial cells and as a mediator of pro‐inflammatory cytokines in vascular and connective tissue cells, these results establish ESE‐1 as an important player in the regulation of inflammation. Cyclooxygenase-2 (COX-2) is a key enzyme in the production of prostaglandins that are major inflammatory agents. COX-2 production is triggered by exposure to various cytokines and to bacterial endotoxins. We present here a novel role for the Ets transcription factor ESE-1 in regulating the COX-2 gene in response to endotoxin and other pro-inflammatory stimuli. We report that the induction of COX-2 expression by lipopolysaccharide (LPS) and pro-inflammatory cytokines correlates with ESE-1 induction in monocyte-macrophages. ESE-1, in turn, binds to several E26 transformation specific (Ets) sites on the COX-2 promoter. In vitro analysis demonstrates that ESE-1 binds to and activates the COX-2 promoter to levels comparable to LPS-mediated induction. Moreover, we provide results showing that the induction of COX-2 by LPS may require ESE-1, as the mutation of the Ets sites in the COX-2 promoter or overexpression of a dominant-negative form of ESE-1 inhibits LPS-mediated COX-2 induction. The effect of ESE-1 on the COX-2 promoter is further enhanced by cooperation with other transcription factors such as nuclear factor- Kappa B and nuclear factor of activated T cells. Neutralization of COX-2 is the goal of many anti-inflammatory drugs. As an activator of COX-2 induction, ESE-1 may become a target for such therapeutics as well. Together with our previous reports of the role of ESE-1 as an inducer of nitric oxide synthase in endothelial cells and as a mediator of pro-inflammatory cytokines in vascular and connective tissue cells, these results establish ESE-1 as an important player in the regulation of inflammation. Cyclooxygenase-2 (COX-2) is a key enzyme in the production of prostaglandins that are major inflammatory agents. COX-2 production is triggered by exposure to various cytokines and to bacterial endotoxins. We present here a novel role for the Ets transcription factor ESE-1 in regulating the COX-2 gene in response to endotoxin and other pro-inflammatory stimuli. We report that the induction of COX-2 expression by lipopolysaccharide (LPS) and pro-inflammatory cytokines correlates with ESE-1 induction in monocyte/macrophages. ESE-1, in turn, binds to several E26 transformation specific (Ets) sites on the COX-2 promoter. In vitro analysis demonstrates that ESE-1 binds to and activates the COX-2 promoter to levels comparable to LPS-mediated induction. Moreover, we provide results showing that the induction of COX-2 by LPS may require ESE-1, as the mutation of the Ets sites in the COX-2 promoter or overexpression of a dominant-negative form of ESE-1 inhibits LPS-mediated COX-2 induction. The effect of ESE-1 on the COX-2 promoter is further enhanced by cooperation with other transcription factors such as nuclear factor-kappaB and nuclear factor of activated T cells. Neutralization of COX-2 is the goal of many anti-inflammatory drugs. As an activator of COX-2 induction, ESE-1 may become a target for such therapeutics as well. Together with our previous reports of the role of ESE-1 as an inducer of nitric oxide synthase in endothelial cells and as a mediator of pro-inflammatory cytokines in vascular and connective tissue cells, these results establish ESE-1 as an important player in the regulation of inflammation. [PUBLICATION ABSTRACT] Cyclooxygenase‐2 (COX‐2) is a key enzyme in the production of prostaglandins that are major inflammatory agents. COX‐2 production is triggered by exposure to various cytokines and to bacterial endotoxins. We present here a novel role for the Ets transcription factor ESE‐1 in regulating the COX‐2 gene in response to endotoxin and other pro‐inflammatory stimuli. We report that the induction of COX‐2 expression by lipopolysaccharide (LPS) and pro‐inflammatory cytokines correlates with ESE‐1 induction in monocyte/macrophages. ESE‐1, in turn, binds to several E26 transformation specific (Ets) sites on the COX‐2 promoter. In vitro analysis demonstrates that ESE‐1 binds to and activates the COX‐2 promoter to levels comparable to LPS‐mediated induction. Moreover, we provide results showing that the induction of COX‐2 by LPS may require ESE‐1, as the mutation of the Ets sites in the COX‐2 promoter or overexpression of a dominant‐negative form of ESE‐1 inhibits LPS‐mediated COX‐2 induction. The effect of ESE‐1 on the COX‐2 promoter is further enhanced by cooperation with other transcription factors such as nuclear factor‐κB and nuclear factor of activated T cells. Neutralization of COX‐2 is the goal of many anti‐inflammatory drugs. As an activator of COX‐2 induction, ESE‐1 may become a target for such therapeutics as well. Together with our previous reports of the role of ESE‐1 as an inducer of nitric oxide synthase in endothelial cells and as a mediator of pro‐inflammatory cytokines in vascular and connective tissue cells, these results establish ESE‐1 as an important player in the regulation of inflammation. |
Author | Prall, Wolf C. Inan, Mehmet S. Choy, Bob K. Oettgen, Peter Gu, Xuesong Goldring, Mary B. Wei, Wanjiang Grall, Franck T. Libermann, Towia A. Gravallese, Ellen M. Cho, Je‐Yoel Zerbini, Luiz F. Goldring, Steven R. |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15794755$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.4049/jimmunol.163.2.963 10.1002/jcp.1112 10.1096/fasebj.12.14.1541 10.1046/j.1432-1033.2000.01778.x 10.1074/jbc.M302076200 10.1128/MCB.17.8.4419 10.1177/107327489800500103 10.1002/art.10942 10.2106/00004623-198365050-00001 10.1016/S0014-5793(01)02422-X 10.1002/(SICI)1097-0142(19960501)77:9<1862::AID-CNCR16>3.0.CO;2-Y 10.1093/molehr/6.6.561 10.3109/03008209709160231 10.1016/S0140-6736(99)12031-2 10.1159/000468614 10.1038/sj.onc.1200978 10.1002/art.1780400207 10.1006/geno.1997.4974 10.1172/JCI117595 10.1359/jbmr.2000.15.6.1138 10.1038/sj.onc.1201427 10.1074/jbc.M306267200 10.1074/jbc.270.42.24965 10.1242/jcs.112.24.4695 10.1074/jbc.272.49.31065 10.1074/jbc.275.9.6259 10.1074/jbc.273.1.110 10.1038/sj.onc.1205503 10.1074/jbc.M308136200 10.1074/jbc.M006507200 10.1038/sj.onc.1202198 10.1038/sj.onc.1201111 10.1002/j.1460-2075.1991.tb08053.x 10.1074/jbc.M001381200 10.1074/jbc.M010692200 10.1093/nar/25.21.4287 10.1074/jbc.M111415200 10.1074/jbc.271.42.26007 10.1074/jbc.M005077200 10.1002/j.1460-2075.1990.tb07394.x 10.1074/jbc.M106865200 |
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References | 2001; 188 1997; 40 2000; 355 2000; 6 1997; 272 1991; 10 1997; 25 2002; 277 1997; 45 1999; 163 2000; 275 2003; 278 1995; 270 1998; 273 1996; 77 2001; 276 2001; 496 1998; 17 2004; 279 2000; 267 2000; 15 1997; 15 1997; 14 1997; 36 2002; 21 1983; 65 1996; 271 2003; 48 1997; 17 1999; 112 1996; 49 1998; 5 1990; 9 1994; 94 1998; 12 e_1_2_23_18_2 e_1_2_23_17_2 e_1_2_23_39_2 e_1_2_23_16_2 e_1_2_23_38_2 e_1_2_23_15_2 e_1_2_23_37_2 e_1_2_23_19_2 e_1_2_23_21_2 e_1_2_23_20_2 e_1_2_23_2_2 e_1_2_23_25_2 e_1_2_23_40_2 e_1_2_23_3_2 e_1_2_23_24_2 e_1_2_23_41_2 e_1_2_23_4_2 e_1_2_23_23_2 e_1_2_23_42_2 e_1_2_23_5_2 e_1_2_23_22_2 e_1_2_23_6_2 e_1_2_23_29_2 e_1_2_23_7_2 e_1_2_23_28_2 e_1_2_23_8_2 e_1_2_23_27_2 e_1_2_23_9_2 e_1_2_23_26_2 e_1_2_23_32_2 e_1_2_23_10_2 e_1_2_23_31_2 e_1_2_23_30_2 e_1_2_23_13_2 e_1_2_23_36_2 e_1_2_23_14_2 e_1_2_23_35_2 e_1_2_23_11_2 e_1_2_23_34_2 e_1_2_23_12_2 e_1_2_23_33_2 |
References_xml | – volume: 17 start-page: 4419 year: 1997 end-page: 4433 article-title: Isolation and characterization of a novel epithelium‐specific transcription factor, ESE‐1, a member of the ets family publication-title: Mol Cell Biol – volume: 112 start-page: 4695 year: 1999 end-page: 4703 article-title: Characterisation of the tumour necrosis factor (TNF)‐(alpha) response elements in the human ICAM‐2 promoter publication-title: J Cell Sci – volume: 277 start-page: 18649 year: 2002 end-page: 18657 article-title: Cyclooxygenase‐2 is overexpressed in her‐2/neu‐positive breast cancer. Evidence for involvement of AP‐1 and PEA3 publication-title: J Biol Chem – volume: 49 start-page: 20 year: 1996 end-page: 37 article-title: Mechanisms controlling the transcription of matrix metalloproteinase genes in normal and neoplastic cells publication-title: Enzyme Protein – volume: 21 start-page: 3934 year: 2002 end-page: 3938 article-title: ErbB2 activation of ESX gene expression publication-title: Oncogene – volume: 14 start-page: 2651 year: 1997 end-page: 2660 article-title: Differential regulation of interstitial collagenase (MMP‐1) gene expression by ETS transcription factors publication-title: Oncogene – volume: 65 start-page: 575 year: 1983 end-page: 584 article-title: The synovial‐like membrane at the bone–cement interface in loose total hip replacements and its proposed role in bone lysis publication-title: J Bone Joint Surg Am – volume: 15 start-page: 1138 year: 2000 end-page: 1146 article-title: Involvement of CCAAT enhancer binding protein transcription factors in the regulation of prostaglandin G/H synthase 2 expression by interleukin‐1 in osteoblastic MC3T3–E1 cells publication-title: J Bone Miner Res – volume: 273 start-page: 110 year: 1998 end-page: 117 article-title: A novel ets‐related transcription factor, ERT/ESX/ESE‐1, regulates expression of the transforming growth factor‐beta type II receptor publication-title: J Biol Chem – volume: 14 start-page: 1617 year: 1997 end-page: 1622 article-title: ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis publication-title: Oncogene – volume: 267 start-page: 6798 year: 2000 end-page: 6809 article-title: Critical role of C/EBPdelta and C/EBPbeta factors in the stimulation of the cyclooxygenase‐2 gene transcription by interleukin‐1beta in articular chondrocytes publication-title: Eur J Biochem – volume: 163 start-page: 963 year: 1999 end-page: 969 article-title: Lipopolysaccharide modulates cyclooxygenase‐2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL‐1 beta and TNF‐alpha publication-title: J Immunol – volume: 270 start-page: 24965 year: 1995 end-page: 24971 article-title: Transcriptional regulation of human prostaglandin‐endoperoxide synthase‐2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin‐6 expression site and cAMP response element publication-title: J Biol Chem – volume: 275 start-page: 23627 year: 2000 end-page: 23635 article-title: An essential role of the nuclear factor of activated T cells in the regulation of the expression of the cyclooxygenase‐2 gene in human T lymphocytes publication-title: J Biol Chem – volume: 276 start-page: 3302 year: 2001 end-page: 3309 article-title: ESE‐1 is a novel transcriptional mediator of inflammation that interacts with NF‐kappa B to regulate the inducible nitric‐oxide synthase gene publication-title: J Biol Chem – volume: 355 start-page: 646 year: 2000 end-page: 648 article-title: COX‐1, COX‐2, and COX‐3 and the future treatment of chronic inflammatory disease publication-title: Lancet – volume: 276 start-page: 3977 year: 2001 end-page: 3982 article-title: Redundancy in the signaling pathways and promoter elements regulating cyclooxygenase‐2 gene expression in endotoxin‐treated macrophage/monocytic cells publication-title: J Biol Chem – volume: 278 start-page: 22563 year: 2003 end-page: 22573 article-title: Myeloid differentiation factor 88‐dependent transcriptional regulation of cyclooxygenase‐2 expression by CpG DNA: role of NF‐kappaB and p38 publication-title: J Biol Chem – volume: 496 start-page: 147 year: 2001 end-page: 151 article-title: Overlapping CRE and E‐box promoter elements can independently regulate COX‐2 gene transcription in macrophages publication-title: FEBS Lett – volume: 6 start-page: 561 year: 2000 end-page: 565 article-title: NF‐kappaB and AP‐1 are required for cyclo‐oxygenase 2 gene expression in amnion epithelial cell line (WISH) publication-title: Mol Hum Reprod – volume: 45 start-page: 456 year: 1997 end-page: 457 article-title: The novel epithelial‐specific Ets transcription factor gene ESX maps to human chromosome 1q32.1 publication-title: Genomics – volume: 276 start-page: 20108 year: 2001 end-page: 20115 article-title: PEA3 is up‐regulated in response to Wnt1 and activates the expression of cyclooxygenase‐2 publication-title: J Biol Chem – volume: 36 start-page: 321 year: 1997 end-page: 335 article-title: ETS sites in the promoters of the matrix metalloproteinases collagenase (MMP‐1) and stromelysin (MMP‐3) are auxiliary elements that regulate basal and phorbol‐induced transcription publication-title: Connect Tissue Res – volume: 279 start-page: 6658 year: 2004 end-page: 6665 article-title: Transcriptional regulation of the cyclooxygenase‐2 gene in macrophages by PU.1 publication-title: J Biol Chem – volume: 40 start-page: 226 year: 1997 end-page: 236 article-title: Involvement of nuclear factor kappa B in the regulation of cyclooxygenase‐2 expression by interleukin‐1 in rheumatoid synoviocytes publication-title: Arthritis Rheum – volume: 77 start-page: 1862 year: 1996 end-page: 1872 article-title: In vitro modulation of tumor progression‐associated properties of hormone refractory prostate carcinoma cell lines by cytokines publication-title: Cancer – volume: 17 start-page: 2719 year: 1998 end-page: 2732 article-title: A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13–15, a region subject to LOH and rearrangement in human carcinoma cell lines publication-title: Oncogene – volume: 9 start-page: 2241 year: 1990 end-page: 2246 article-title: The collagenase gene promoter contains a TPA and oncogene‐responsive unit encompassing the PEA3 and AP‐1 binding sites publication-title: EMBO J – volume: 272 start-page: 31065 year: 1997 end-page: 31072 article-title: Tumor necrosis factor‐alpha inversely regulates prostaglandin D2 and prostaglandin E2 production in murine macrophages. Synergistic action of cyclic AMP on cyclooxygenase‐2 expression and prostaglandin E2 synthesis publication-title: J Biol Chem – volume: 94 start-page: 2307 year: 1994 end-page: 2316 article-title: Interleukin‐1 beta‐modulated gene expression in immortalized human chondrocytes publication-title: J Clin Invest – volume: 15 start-page: 2449 year: 1997 end-page: 2462 article-title: A novel epithelial‐expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer publication-title: Oncogene – volume: 25 start-page: 4287 year: 1997 end-page: 4295 article-title: The expression of a novel, epithelium‐specific ets transcription factor is restricted to the most differentiated layers in the epidermis publication-title: Nucleic Acids Res – volume: 12 start-page: 1541 year: 1998 end-page: 1550 article-title: The epithelium‐specific ets transcription factor ESX is associated with mammary gland development and involution publication-title: FASEB J – volume: 188 start-page: 243 year: 2001 end-page: 252 article-title: Role of transcription factor Ets‐1 in the apoptosis of human vascular endothelial cells publication-title: J Cell Physiol – volume: 5 start-page: 25 year: 1998 end-page: 33 article-title: Large granular lymphocyte leukemia publication-title: Cancer Control – volume: 271 start-page: 26007 year: 1996 end-page: 26012 article-title: ELF‐1 interacts with and transactivates the IgH enhancer pi site publication-title: J Biol Chem – volume: 279 start-page: 18694 year: 2004 end-page: 18700 article-title: Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase‐2 by nitric oxide in colorectal cancer cells publication-title: J Biol Chem – volume: 276 start-page: 40769 year: 2001 end-page: 40777 article-title: The transcription factor C/EBPbeta is essential for inducible expression of the cox‐2 gene in macrophages but not in fibroblasts publication-title: J Biol Chem – volume: 275 start-page: 6259 year: 2000 end-page: 6266 article-title: Transcriptional activation of the cyclooxygenase‐2 gene in endotoxin‐treated RAW 264.7 macrophages publication-title: J Biol Chem – volume: 48 start-page: 1249 year: 2003 end-page: 1260 article-title: Responses to the proinflammatory cytokines interleukin‐1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB‐mediated induction of the Ets transcription factor ESE‐1 publication-title: Arthritis Rheum – volume: 10 start-page: 1127 year: 1991 end-page: 1134 article-title: The c‐Ets oncoprotein activates the stromelysin promoter through the same elements as several non‐nuclear oncoproteins publication-title: EMBO J – ident: e_1_2_23_4_2 doi: 10.4049/jimmunol.163.2.963 – ident: e_1_2_23_16_2 doi: 10.1002/jcp.1112 – ident: e_1_2_23_31_2 doi: 10.1096/fasebj.12.14.1541 – ident: e_1_2_23_11_2 doi: 10.1046/j.1432-1033.2000.01778.x – ident: e_1_2_23_15_2 doi: 10.1074/jbc.M302076200 – ident: e_1_2_23_24_2 doi: 10.1128/MCB.17.8.4419 – ident: e_1_2_23_28_2 doi: 10.1177/107327489800500103 – ident: e_1_2_23_22_2 doi: 10.1002/art.10942 – ident: e_1_2_23_39_2 doi: 10.2106/00004623-198365050-00001 – ident: e_1_2_23_13_2 doi: 10.1016/S0014-5793(01)02422-X – ident: e_1_2_23_42_2 doi: 10.1002/(SICI)1097-0142(19960501)77:9<1862::AID-CNCR16>3.0.CO;2-Y – ident: e_1_2_23_8_2 doi: 10.1093/molehr/6.6.561 – ident: e_1_2_23_34_2 doi: 10.3109/03008209709160231 – ident: e_1_2_23_5_2 doi: 10.1016/S0140-6736(99)12031-2 – ident: e_1_2_23_2_2 doi: 10.1159/000468614 – ident: e_1_2_23_29_2 doi: 10.1038/sj.onc.1200978 – ident: e_1_2_23_12_2 doi: 10.1002/art.1780400207 – ident: e_1_2_23_40_2 doi: 10.1006/geno.1997.4974 – ident: e_1_2_23_38_2 doi: 10.1172/JCI117595 – ident: e_1_2_23_6_2 doi: 10.1359/jbmr.2000.15.6.1138 – ident: e_1_2_23_25_2 doi: 10.1038/sj.onc.1201427 – ident: e_1_2_23_20_2 doi: 10.1074/jbc.M306267200 – ident: e_1_2_23_27_2 doi: 10.1074/jbc.270.42.24965 – ident: e_1_2_23_37_2 doi: 10.1242/jcs.112.24.4695 – ident: e_1_2_23_3_2 doi: 10.1074/jbc.272.49.31065 – ident: e_1_2_23_10_2 doi: 10.1074/jbc.275.9.6259 – ident: e_1_2_23_30_2 doi: 10.1074/jbc.273.1.110 – ident: e_1_2_23_32_2 doi: 10.1038/sj.onc.1205503 – ident: e_1_2_23_19_2 doi: 10.1074/jbc.M308136200 – ident: e_1_2_23_21_2 doi: 10.1074/jbc.M006507200 – ident: e_1_2_23_26_2 doi: 10.1038/sj.onc.1202198 – ident: e_1_2_23_33_2 doi: 10.1038/sj.onc.1201111 – ident: e_1_2_23_36_2 doi: 10.1002/j.1460-2075.1991.tb08053.x – ident: e_1_2_23_7_2 doi: 10.1074/jbc.M001381200 – ident: e_1_2_23_17_2 doi: 10.1074/jbc.M010692200 – ident: e_1_2_23_23_2 doi: 10.1093/nar/25.21.4287 – ident: e_1_2_23_18_2 doi: 10.1074/jbc.M111415200 – ident: e_1_2_23_41_2 doi: 10.1074/jbc.271.42.26007 – ident: e_1_2_23_14_2 doi: 10.1074/jbc.M005077200 – ident: e_1_2_23_35_2 doi: 10.1002/j.1460-2075.1990.tb07394.x – ident: e_1_2_23_9_2 doi: 10.1074/jbc.M106865200 |
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Snippet | Cyclooxygenase‐2 (COX‐2) is a key enzyme in the production of prostaglandins that are major inflammatory agents. COX‐2 production is triggered by exposure to... Cyclooxygenase-2 (COX-2) is a key enzyme in the production of prostaglandins that are major inflammatory agents. COX-2 production is triggered by exposure to... |
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SubjectTerms | Animals Base Sequence COX‐2 Cyclooxygenase 2 Cytokines DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enzyme Induction - physiology Enzymes ESE‐1 Ets Gene expression Humans Immune system Lipopolysaccharides - metabolism LPS Membrane Proteins Mice Molecular Sequence Data Monocytes - metabolism Mutation NFATC Transcription Factors Nitric oxide Nuclear Proteins - metabolism Promoter Regions, Genetic Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandin-Endoperoxide Synthases - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-ets Transcription Factors - genetics Transcription Factors - metabolism |
Title | The Ets transcription factor ESE‐1 mediates induction of the COX‐2 gene by LPS in monocytes |
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