Changes of telomere status with aging: An update

Accumulated data have shown that most human somatic cells or tissues show irreversible telomere shortening with age, and that there are strong associations between telomere attrition and aging‐related diseases, including cancers, diabetes and cognitive disorders. Although it has been largely accepte...

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Published inGeriatrics & gerontology international Vol. 16; no. S1; pp. 30 - 42
Main Authors Ishikawa, Naoshi, Nakamura, Ken-Ichi, Izumiyama-Shimomura, Naotaka, Aida, Junko, Matsuda, Yoko, Arai, Tomio, Takubo, Kaiyo
Format Journal Article
LanguageEnglish
Published Japan Blackwell Publishing Ltd 01.03.2016
Subjects
Aging
Aging - genetics
Blotting, Southern
Chromosomes
Gerontology
Humans
In Situ Hybridization, Fluorescence
precancerous states
quantitative fluorescence in situ hybridization
replicative senescence
telomere
Telomere - physiology
Telomere Homeostasis - physiology
terminal restriction fragment
quantitative fluorescence in situ hybridization
replicative senescence
precancerous states
terminal restriction fragment
telomere
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Abstract Accumulated data have shown that most human somatic cells or tissues show irreversible telomere shortening with age, and that there are strong associations between telomere attrition and aging‐related diseases, including cancers, diabetes and cognitive disorders. Although it has been largely accepted that telomere attrition is one of the major causes of aging‐related disorders, critical aspects of telomere biology remain unresolved, especially the lack of standardized methodology for quantification of telomere length. Another frustrating issue is that no potentially promising methods for safe prevention of telomere erosion, or for telomere elongation, have been devised. Here, we review several methods for quantification of telomere length currently utilized worldwide, considering their advantages and drawbacks. We also summarize the results of our recent studies of human cells and tissues, mainly using quantitative fluorescence in situ hybridization and Southern blotting, including those derived from patients with progeria‐prone Werner syndrome and trisomy 21, and several strains of induced pluripotent stem cells. We discuss the possible merits of using telomere shortness as an indicator, or a new marker, for diagnosis of precancerous states and aging‐related disorders. In addition, we describe newly found factors that are thought to impact telomere dynamics, providing a new avenue for examining the unsolved issues related to telomere restoration and maintenance. Geriatr Gerontol Int 2016; 16 (Suppl. 1): 30–42.
AbstractList Accumulated data have shown that most human somatic cells or tissues show irreversible telomere shortening with age, and that there are strong associations between telomere attrition and aging‐related diseases, including cancers, diabetes and cognitive disorders. Although it has been largely accepted that telomere attrition is one of the major causes of aging‐related disorders, critical aspects of telomere biology remain unresolved, especially the lack of standardized methodology for quantification of telomere length. Another frustrating issue is that no potentially promising methods for safe prevention of telomere erosion, or for telomere elongation, have been devised. Here, we review several methods for quantification of telomere length currently utilized worldwide, considering their advantages and drawbacks. We also summarize the results of our recent studies of human cells and tissues, mainly using quantitative fluorescence in situ hybridization and Southern blotting, including those derived from patients with progeria‐prone Werner syndrome and trisomy 21, and several strains of induced pluripotent stem cells. We discuss the possible merits of using telomere shortness as an indicator, or a new marker, for diagnosis of precancerous states and aging‐related disorders. In addition, we describe newly found factors that are thought to impact telomere dynamics, providing a new avenue for examining the unsolved issues related to telomere restoration and maintenance. Geriatr Gerontol Int 2016; 16 (Suppl. 1): 30–42.
Accumulated data have shown that most human somatic cells or tissues show irreversible telomere shortening with age, and that there are strong associations between telomere attrition and aging-related diseases, including cancers, diabetes and cognitive disorders. Although it has been largely accepted that telomere attrition is one of the major causes of aging-related disorders, critical aspects of telomere biology remain unresolved, especially the lack of standardized methodology for quantification of telomere length. Another frustrating issue is that no potentially promising methods for safe prevention of telomere erosion, or for telomere elongation, have been devised. Here, we review several methods for quantification of telomere length currently utilized worldwide, considering their advantages and drawbacks. We also summarize the results of our recent studies of human cells and tissues, mainly using quantitative fluorescence in situ hybridization and Southern blotting, including those derived from patients with progeria-prone Werner syndrome and trisomy 21, and several strains of induced pluripotent stem cells. We discuss the possible merits of using telomere shortness as an indicator, or a new marker, for diagnosis of precancerous states and aging-related disorders. In addition, we describe newly found factors that are thought to impact telomere dynamics, providing a new avenue for examining the unsolved issues related to telomere restoration and maintenance.
Accumulated data have shown that most human somatic cells or tissues show irreversible telomere shortening with age, and that there are strong associations between telomere attrition and aging‐related diseases, including cancers, diabetes and cognitive disorders. Although it has been largely accepted that telomere attrition is one of the major causes of aging‐related disorders, critical aspects of telomere biology remain unresolved, especially the lack of standardized methodology for quantification of telomere length. Another frustrating issue is that no potentially promising methods for safe prevention of telomere erosion, or for telomere elongation, have been devised. Here, we review several methods for quantification of telomere length currently utilized worldwide, considering their advantages and drawbacks. We also summarize the results of our recent studies of human cells and tissues, mainly using quantitative fluorescence in situ hybridization and Southern blotting, including those derived from patients with progeria‐prone Werner syndrome and trisomy 21, and several strains of induced pluripotent stem cells. We discuss the possible merits of using telomere shortness as an indicator, or a new marker, for diagnosis of precancerous states and aging‐related disorders. In addition, we describe newly found factors that are thought to impact telomere dynamics, providing a new avenue for examining the unsolved issues related to telomere restoration and maintenance. Geriatr Gerontol Int 2016; 16 (Suppl. 1): 30–42.
Accumulated data have shown that most human somatic cells or tissues show irreversible telomere shortening with age, and that there are strong associations between telomere attrition and aging-related diseases, including cancers, diabetes and cognitive disorders. Although it has been largely accepted that telomere attrition is one of the major causes of aging-related disorders, critical aspects of telomere biology remain unresolved, especially the lack of standardized methodology for quantification of telomere length. Another frustrating issue is that no potentially promising methods for safe prevention of telomere erosion, or for telomere elongation, have been devised. Here, we review several methods for quantification of telomere length currently utilized worldwide, considering their advantages and drawbacks. We also summarize the results of our recent studies of human cells and tissues, mainly using quantitative fluorescence insitu hybridization and Southern blotting, including those derived from patients with progeria-prone Werner syndrome and trisomy 21, and several strains of induced pluripotent stem cells. We discuss the possible merits of using telomere shortness as an indicator, or a new marker, for diagnosis of precancerous states and aging-related disorders. In addition, we describe newly found factors that are thought to impact telomere dynamics, providing a new avenue for examining the unsolved issues related to telomere restoration and maintenance. Geriatr Gerontol Int 2016; 16 (Suppl. 1): 30-42.
Author Izumiyama-Shimomura, Naotaka
Nakamura, Ken-Ichi
Takubo, Kaiyo
Aida, Junko
Arai, Tomio
Ishikawa, Naoshi
Matsuda, Yoko
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  fullname: Izumiyama-Shimomura, Naotaka
  organization: Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
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Cites_doi 10.1111/j.1749-0774.2009.00066.x
10.1073/pnas.95.10.5607
10.1007/s11357-011-9280-y
10.1016/j.tice.2014.08.005
10.1016/j.exger.2005.02.008
10.1007/s13577‐015‐0119‐1
10.1016/0022-2836(92)90096-3
10.1093/nar/30.10.e47
10.1186/1756‐0500‐7‐877
10.1038/nature13959
10.1016/j.cell.2013.10.041
10.1093/ije/dyv166
10.1152/physrev.00026.2007
10.1016/j.mad.2010.08.007
10.1126/science.aaa6246
10.1126/science.aaa6592
10.1111/j.1447-0594.2010.00605.x
10.18632/aging.100315
10.1126/science.1172539
10.1016/S0968-0004(02)02110-2
10.1371/journal.pone.0063860
10.1006/excr.1995.1306
10.1111/j.1365‐2141.2009.07598.x
10.1101/gad.1346005
10.1111/petr.12431
10.1038/nprot.2010.124
10.0116/j.humpath.2008.04.005
10.1002/(SICI)1097-0320(19990801)36:4<267::AID-CYTO1>3.0.CO;2-O
10.1016/j.mrfmmm.2011.04.003
10.1007/s00268-012-1453-z
10.1016/S0092-8674(00)80932-0
10.1093/hmg/5.5.685
10.1111/j.1600-0714.2011.01120.x
10.1016/j.humpath.2006.11.023
10.1016/S0092-8674(01)00504-9
10.1158/1078-0432.CCR-0984-03
10.1016/j.exger.2006.06.036
10.1038/nature14513
10.1093/nar/gkn1027
10.1016/j.exger.2007.05.003
10.1002/path.2817
10.15288/qjsa.1972.33.171
10.1016/S0140-6736(03)12384-7
10.1042/CBI20110460
10.1073/pnas.95.18.10614
10.1016/0014-4827(65)90211-9
10.1038/nature08792
10.1073/pnas.0407162101
10.1007/s13577‐011‐0016‐1
10.1002/hep.23072
10.1016/j.ejca.2009.10.018
10.1016/j.cell.2008.06.049
10.1080/00365520902718705
10.2144/01316bc02
10.1016/j.exger.2008.06.001
10.1038/35020592
10.1016/0531-5565(80)90083-2
10.1016/j.cell.2006.07.024
10.1371/journal.pgen.1002696
10.1210/jc.2014-1222
10.1093/ije/dyv169
10.1016/0092-8674(84)90301-5
10.1046/j.1523-1747.2002.19523.x
10.1016/j.ajhg.2007.10.004
10.1126/science.1260825
10.1093/ajcn/72.4.912
10.1093/gerona/55.11.B533
10.1007/s11357-999-0011-6
10.1016/j.mad.2007.10.009
10.1177/0192623308329476
10.1371/journal.pone.0093749
10.1093/ije/dyv167
10.4236/ajac.2014.512086
10.1111/2041-210X.12161
10.1016/j.tice.2013.07.003
10.1371/journal.pone.0117575
10.1016/j.exphem.2010.06.010
10.1002/path.2704
10.1016/j.urolonc.2012.12.005
10.1038/ncb2070
10.1038/517563a
10.1016/S0531-5565(01)00218-2
10.1016/j.gene.2013.09.086
10.1126/science.279.5349.349
10.1002/ijc.26296
10.1093/ije/dyv170
10.1158/1055‐9965.EPI‐13‐0409
10.1038/nature10084
10.1038/srep02401
10.1038/ng989
10.1007/BF02346184
10.1038/nprot.2006.263
10.1016/j.cell.2013.10.019
10.1038/cr.2011.120
10.1038/hdy.2011.10
10.1146/annurev-physiol-030212-183653
10.1016/j.humpath.2013.10.009
10.1101/gad.439107
10.1038/ng1084
10.1038/nrc2275
10.1182/blood‐2008‐05‐153445
10.1093/ije/dyv191
10.1073/pnas.85.18.6622
10.1101/gad.233395.113
10.1038/nature02118
10.1038/nature13193
10.1016/0014-4827(61)90192-6
10.1038/ng0198-018
10.1038/345458a0
10.1038/346866a0
10.1136/bmj.g6674
10.1038/nature10600
10.1038/ncb1275
10.1038/350569a0
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Keywords quantitative fluorescence in situ hybridization
replicative senescence
precancerous states
terminal restriction fragment
telomere
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References Anderson RM, Shanmuganayagam D, Weindruch R. Caloric restriction and aging: studies in mice and monkeys. Toxicol Pathol 2009; 37: 47-51. doi: 10.1177/0192623308329476; PMCID: PMC3734859.
Martin-Ruiz CM, Baird D, Roger L et al. Is Southern blotting necessary to measure telomere length reproducibly? Authors' response to: commentary: the reliability of telomere length measurements. Int J Epidemiol First published online September 24 2015; 44: 1686-1687. doi: 10.1093/ije/dyv169; Response.
Kaji K, Ohta T, Horie N, Naru E, Hasegawa M, Kanda N. Donor age reflects the replicative lifespan of human fibroblasts in culture. Hum Cell 2009; 22: 38-42. PMID: 19385098.
Hemann MT, Strong MA, Hao LY, Greider CW. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 2001; 107: 67-77.
Shiraishi H, Mikami T, Aida J et al. Telomere shortening in Barrett's mucosa and esophageal adenocarcinoma and its association with loss of heterozygosity. Scand J Gastroenterol 2009; 44: 538-544.
Levy MZ, Allsopp RC, Futcher AB, Greider CW, Harley CB. Telomere end-replication problem and cell aging. J Mol Biol 1992; 225: 951-960.
Verhulst S, Susser E, Factor-Litvak PR et al. Commentary: the reliability of telomere length measurements. Int J Epidemiol First published online September 24 2015; 44: 1683-1686. doi: 10.1093/ije/dyv166; Commentary.
Aida J, Yokoyama A, Izumiyama-Shimomura N et al. Alcoholics show reduced telomere length in the oesophagus. J Pathol 2011; 223: 410-416.
Hastie ND, Dempster M, Dunlop MG et al. Telomere reduction in human colorectal carcinoma and with ageing. Nature 1990; 346: 866-868.
Jun JI, Lau LF. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol 2010; 12: 676-685.
Harley CB. Telomerase and cancer therapeutics. Nat Rev Cancer 2008; 8: 167-179.
d'Adda di Fagagna F, Reaper PM, Clay-Farrace L et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003; 426: 194-198.
Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676.
Cunningham JM, Johnson RA, Litzelman K et al. Telomere length varies by DNA extraction method: implications for epidemiologic research. Cancer Epidemiol Biomarkers Prev 2013; 22: 2047-2054. doi: 10.1158/1055-9965.EPI-13-0409.
Vaziri H, Schaechter F, Uchida I et al. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 1993; 52: 661-667.
Kawano Y, Ishikawa N, Aida J et al. Q-FISH measurement of hepatocyte telomere lengths in donor liver and graft after pediatric living-donor liver transplantation: donor age affects telomere length sustainability. PLoS ONE 2014; 9: e93749. http://dx.plos.org/10.1371/journal.pone.0093749.
Schwartz DC, Cantor CR. Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis. Cell 1984; 37: 67-75.
Kappei D, Londoño-Vallejo JA. Telomere length inheritance and aging. Mech Ageing Dev 2008; 129: 17-26.
Wodarz D, Zauber AG. Cancer: risk factors and random chances. Nature 2015; 517: 563-564. doi: 10.1038/517563a.
Baerlocher GM, Vulto I, de Jong G, Lansdorp PM. Flow cytometry and FISH to measure the average length of telomeres (flow FISH). Nat Protoc 2006; 1: 2365-2376.
Agarwal S, Daley GQ. Telomere dynamics in dyskeratosis congenita: the long and the short of iPS. Cell Res 2011; 21: 1157-1160.
Kumazaki T, Kurata S, Matsuo T, Mitsui Y, Takahashi T. Establishment of human induced pluripotent stem cell lines from normal fibroblast TIG-1. Hum Cell 2011; 24: 96-103. doi: 10.1007/s13577-011-0016-1.
van Steensel B, Smogorzewska A, de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell 1998; 92: 401-413.
Martin-Ruiz CM, Baird D, Roger L et al. Reproducibility of telomere length assessment: authors' response to Damjan Krstajic and Ljubomir Buturovic. Int J Epidemiol First published online September 24 2015; 44: 1739-1741. doi: 10.1093/ije/dyv170; Response.
Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res 2002; 30: e47. PMID: 12000852.
Nakamura K, Izumiyama-Shimomura N, Sawabe M et al. Comparative analysis of telomere lengths and erosion with age in human epidermis and lingual epithelium. J Invest Dermatol 2002; 119: 1014-1019.
Blackburn EH. Structure and function of telomeres. Nature 1991; 350: 569-573.
Takubo K, Izumiyama-Shimomura N, Honma N et al. Telomere lengths are characteristic in each human individual. Exp Gerontol 2002; 37: 523-531.
Fontana L, Partridge L, Longo VD. Extending healthy life span - from yeast to humans. Science 2010; 328: 321-326. doi: 10.1126/science.1172539; Review. PMID: 20395504.
Batista LF, Pech MF, Zhong FL et al. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature 2011; 474: 399-402. doi: 10.1038/nature10084.
Muñoz-Espín D, Cañamero M, Maraver A et al. Programmed cell senescence during mammalian embryonic development. Cell 2013; 155: 1104-1118.
Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965; 37: 614-636.
Martin GM, Sprague CA, Epstein CJ. Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype. Lab Invest 1970; 23: 86-92. PMID: 5431223.
Kim H, Oh BK, Roncalli M et al. Large liver cell change in hepatitis B virus-related liver cirrhosis. Hepatology 2009; 50: 752-762.
Aida J, Izumiyama-Shimomura N, Nakamura K et al. Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium. Exp Gerontol 2008; 43: 833-839.
Tilman D, Clark M. Global diets link environmental sustainability and human health. Nature 2014; 515: 518-522. doi: 10.1038/nature13959.
Frenck RW Jr, Blackburn EH, Shannon KM. The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci U S A 1998; 95: 5607-5610. PMCID: PMC20425.
Walne AJ, Dokal I. Advances in the understanding of dyskeratosis congenita. Br J Haematol 2009; 145: 164-172. doi: 10.1111/j.1365-2141.2009.07598.x.
van Deursen JM. The role of senescent cells in ageing. Nature 2014; 509: 439-446. doi: 10.1038/nature13193.
Sanada Y, Aida J, Kawano Y et al. Hepatocellular telomere length in biliary atresia measured by Q-FISH. World J Surg 2012; 36: 908-916.
Hu FB, Rimm EB, Stampfer MJ, Ascherio A, Spiegelman D, Willett WC. Prospective study of major dietary patterns and risk of coronary heart disease in men. Am J Clin Nutr 2000; 72: 912-921.
Terai M, Izumiyama-Shimomura N, Aida J et al. Association of telomere shortening in myocardium with heart weight gain and cause of death. Sci Rep 2013; 3: 2401. doi: 10.1038/srep02401; PMCID: PMC3738945.
Kimura M, Gazitt Y, Cao X, Zhao X, Lansdorp PM, Aviv A. Synchrony of telomere length among hematopoietic cells. Exp Hematol 2010; 38: 854-859.
Storer M, Mas A, Robert-Moreno A et al. Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell 2013; 155: 1119-1130.
Aida J, Kobayashi T, Saku T et al. Short telomeres in an oral precancerous lesion: Q-FISH analysis of leukoplakia. J Oral Pathol Med 2012; 41: 372-378.
Bodnar AG, Ouellette M, Frolkis M et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349-352.
Matsuda Y, Ishiwata T, Izumiyama-Shimomura N et al. Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and without cancer in the pancreas. PLoS ONE 2014; 10: e0117575.
Artandi SE, Chang S, Lee SL et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000; 406: 641-645.
Moyzis RK, Buckingham JM, Cram LS et al. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci U S A 1988; 85: 6622-6626.
Epel ES, Blackburn EH, Lin J et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A 2004; 101: 17312-17315. PMID: 15574496.
Tomasetti C, Vogelstein B. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 2015; 347: 78-81. doi: 10.1126/science.1260825.
Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345: 458-460.
Yokoyama A, Hirota T, Omori T et al. Development of squamous neoplasia in esophageal iodine-unstained lesions and the alcohol and aldehyde dehydrogenase genotypes of Japanese alcoholic men. Int J Cancer 2012; 130: 2949-2960. doi: 10.1002/ijc.26296.
Poon SSS, Lansdorp PM. Quantitative Fluorescence In Situ Hybridization (Q-FISH). Curr Protoc Cell Biol 2001; 18: 18.4.1-18.4.21.
Ohashi M, Aizawa S, Ooka H et al. A new human diploid cell strain, TIG-1, for the research on cellular aging. Exp Gerontol 1980; 15: 121-133.
Denham J, Marques FZ, Charchar FJ. Leukocyte telomere length variation due to DNA extraction method. BMC Res Notes 2014; 7: 877. doi: 10.1186/1756-0500-7-877; PMID: 25475541.
Hayashi MT, Cesare AJ, Rivera T, Karlseder J. Cell death during crisis is mediated by mitotic telomere deprotection. Nature 2015; 522: 492-496. doi: 10.1038/nature14513.
Crous-Bou M, Fung TT, Prescott J et al. Mediterranean diet and telomere length in Nurses' Health Study: population based cohort study. BMJ 2014; 349: g6674. doi: 10.1136/bmj.g6674.
Poon SSS, Martens UM, Ward RK, Lansdorp PM. Telomere length measurements using digital fluorescence microscopy. Cytometry 1999; 36: 267-278.
O'Sullivan JN, Bronner MP, Brentnall TA et al. Chromosomal instability in ulcerative colitis is related to telomere shortening. Nat Genet 2002; 32: 280-284.
Martens UM, Zijlmans JM, Poon SSS et al. Short telomeres on human chromosome 17p. Nat Genet 1998; 18: 76-80.
Allsopp RC, Chang E, Kashefi-Aazam M et al. Telomere shortening is associated with cell division in vitro and in vivo. Exp Cell Res 1995; 220: 194-220.
Savage SA, Giri N, Baerlocher GM, Orr N
2010; 12
2011; 479
1991; 350
2010; 10
2013; 3
1990; 345
1990; 346
2010; 464
2008; 39
2010; 221
1998; 279
2014; 28
2013; 8
2014; 533
2011; 474
1998; 18
2012; 130
2000; 406
1970; 23
1998; 92
1988; 85
2008; 112
1998; 95
2010; 5
2014; 99
2014; 10
2010; 38
2015; 522
2010; 328
2000; 72
1999; 22
2008; 129
2014; 46
1965; 37
2012; 36
2011; 3
2012; 34
2014; 45
1996; 97
2003; 33
2006; 41
2005; 19
2010; 46
1984; 37
2013; 75
1993; 52
1999; 36
2005; 7
2015; 517
2008; 43
2008; 134
2016; 29
2014; 32
2001; 31
2012; 41
2009; 44
2013; 22
2015; 347
2008; 8
2002; 119
2001; 107
2007; 38
2014; 5
2001
2009; 50
2015; 44
2013; 155
2011; 21
2011; 24
2001; 18
2014; 9
2007; 21
1996; 5
2006; 126
2014; 7
2003; 361
2004; 101
2014; 515
2009; 22
2011; 730
2002; 37
2000; 55A
2015; 19
2002; 30
2013; 45
2002; 32
1992; 225
2005; 40
2006
2006; 1
2004; 10
2002; 27
2014; 349
2011; 104
1980; 15
2011; 223
2003; 426
2014; 509
2009; 145
2010; 131
2008; 88
2007; 42
1995; 220
1961; 25
2008; 82
1972; 33
2009; 37
2012; 8
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Vaziri H (e_1_2_14_7_1) 1993; 52
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Sambrook J (e_1_2_14_32_1) 2001
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Poon SSS (e_1_2_14_40_1) 2001; 18
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Chen J‐L (e_1_2_14_84_1) 2006
Martin GM (e_1_2_14_119_1) 1970; 23
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Cristofari G (e_1_2_14_83_1) 2006
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e_1_2_14_118_1
References_xml – volume: 517
  start-page: 563
  year: 2015
  end-page: 564
  article-title: Cancer: risk factors and random chances
  publication-title: Nature
– volume: 426
  start-page: 194
  year: 2003
  end-page: 198
  article-title: A DNA damage checkpoint response in telomere‐initiated senescence
  publication-title: Nature
– volume: 37
  start-page: e21
  year: 2009
  article-title: Telomere length measurement by a novel monochrome multiplex quantitative PCR method
  publication-title: Nucleic Acids Res
– volume: 43
  start-page: 833
  year: 2008
  end-page: 839
  article-title: Basal cells have longest telomeres measured by tissue Q‐FISH method in lingual epithelium
  publication-title: Exp Gerontol
– volume: 85
  start-page: 6622
  year: 1988
  end-page: 6626
  article-title: A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
  publication-title: Proc Natl Acad Sci U S A
– volume: 44
  start-page: 1738
  year: 2015
  end-page: 1739
  article-title: Reproducibility of telomere length assessment
  publication-title: Int J Epidemiol
– volume: 99
  start-page: 2771
  year: 2014
  end-page: 2777
  article-title: Beta cell telomere attrition in diabetes: inverse correlation between HbA1c and telomere length
  publication-title: J Clin Endocrinol Metab
– start-page: 21
  year: 2006
  end-page: 47
– volume: 88
  start-page: 557
  year: 2008
  end-page: 579
  article-title: Telomeres and aging
  publication-title: Physiol Rev
– volume: 44
  start-page: 1686
  year: 2015
  end-page: 1687
  article-title: Is Southern blotting necessary to measure telomere length reproducibly? Authors’ response to: commentary: the reliability of telomere length measurements
  publication-title: Int J Epidemiol
– volume: 36
  start-page: 908
  year: 2012
  end-page: 916
  article-title: Hepatocellular telomere length in biliary atresia measured by Q‐FISH
  publication-title: World J Surg
– volume: 3
  start-page: 417
  year: 2011
  end-page: 429
  article-title: Accelerated in vivo epidermal telomere loss in Werner syndrome
  publication-title: Aging
– volume: 52
  start-page: 661
  year: 1993
  end-page: 667
  article-title: Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
  publication-title: Am J Hum Genet
– volume: 134
  start-page: 657
  year: 2008
  end-page: 667
  article-title: Senescence of activated stellate cells limits liver fibrosis
  publication-title: Cell
– volume: 119
  start-page: 1014
  year: 2002
  end-page: 1019
  article-title: Comparative analysis of telomere lengths and erosion with age in human epidermis and lingual epithelium
  publication-title: J Invest Dermatol
– volume: 44
  start-page: 538
  year: 2009
  end-page: 544
  article-title: Telomere shortening in Barrett's mucosa and esophageal adenocarcinoma and its association with loss of heterozygosity
  publication-title: Scand J Gastroenterol
– volume: 75
  start-page: 685
  year: 2013
  end-page: 705
  article-title: Aging, cellular senescence,and cancer
  publication-title: Annu Rev Physiol
– volume: 5
  start-page: 1596
  year: 2010
  end-page: 1607
  article-title: Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths
  publication-title: Nat Protoc
– volume: 145
  start-page: 164
  year: 2009
  end-page: 172
  article-title: Advances in the understanding of dyskeratosis congenita
  publication-title: Br J Haematol
– volume: 279
  start-page: 349
  year: 1998
  end-page: 352
  article-title: Extension of life‐span by introduction of telomerase into normal human cells
  publication-title: Science
– volume: 3
  start-page: 2401
  year: 2013
  article-title: Association of telomere shortening in myocardium with heart weight gain and cause of death
  publication-title: Sci Rep
– volume: 46
  start-page: 430
  year: 2010
  end-page: 438
  article-title: Telomere lengths in the oral epithelia with and without carcinoma
  publication-title: Eur J Cancer
– volume: 21
  start-page: 1157
  year: 2011
  end-page: 1160
  article-title: Telomere dynamics in dyskeratosis congenita: the long and the short of iPS
  publication-title: Cell Res
– volume: 220
  start-page: 194
  year: 1995
  end-page: 220
  article-title: Telomere shortening is associated with cell division in vitro and in vivo
  publication-title: Exp Cell Res
– volume: 104
  start-page: 371
  year: 2011
  article-title: Telomere measurement tools: telometric produces biased estimates of telomere length
  publication-title: Heredity
– volume: 10
  start-page: 3317
  year: 2004
  end-page: 3326
  article-title: Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis
  publication-title: Clin Cancer Res
– volume: 92
  start-page: 401
  year: 1998
  end-page: 413
  article-title: TRF2 protects human telomeres from end‐to‐end fusions
  publication-title: Cell
– volume: 22
  start-page: 95
  year: 1999
  end-page: 99
  article-title: Telomere shortening with aging in human esophageal mucosa
  publication-title: Age (Omaha)
– volume: 36
  start-page: 519
  year: 2012
  end-page: 527
  article-title: Establishment of ultra long‐lived cell lines by transfection of TERT into normal human fibroblast TIG‐1 and their characterization
  publication-title: Cell Biol Int
– volume: 126
  start-page: 663
  year: 2006
  end-page: 676
  article-title: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
  publication-title: Cell
– start-page: 49
  year: 2006
  end-page: 79
– volume: 8
  start-page: e63860
  year: 2013
  article-title: Telomere shortening in the esophagus of Japanese alcoholics: relationaships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history
  publication-title: PLoS ONE
– volume: 19
  start-page: 2100
  year: 2005
  end-page: 2110
  article-title: Shelterin: the protein complex that shapes and safeguards human telomeres
  publication-title: Genes Dev
– volume: 25
  start-page: 585
  year: 1961
  end-page: 621
  article-title: The serial cultivation of human diploid cell strains
  publication-title: Exp Cell Res
– volume: 10
  start-page: S197
  issue: s1
  year: 2010
  end-page: S206
  article-title: Changes of telomere length with aging
  publication-title: Geriatr Gerontol Int
– volume: 5
  start-page: 775
  year: 2014
  end-page: 783
  article-title: Determination of telomere length by the quantitative fluorescence in situ hybridization (Q‐FISH) method
  publication-title: Am J Anal Chem
– volume: 155
  start-page: 1119
  year: 2013
  end-page: 1130
  article-title: Senescence is a developmental mechanism that contributes to embryonic growth and patterning
  publication-title: Cell
– volume: 522
  start-page: 492
  year: 2015
  end-page: 496
  article-title: Cell death during crisis is mediated by mitotic telomere deprotection
  publication-title: Nature
– volume: 129
  start-page: 17
  year: 2008
  end-page: 26
  article-title: Telomere length inheritance and aging
  publication-title: Mech Ageing Dev
– volume: 474
  start-page: 399
  year: 2011
  end-page: 402
  article-title: Telomere shortening and loss of self‐renewal in dyskeratosis congenita induced pluripotent stem cells
  publication-title: Nature
– volume: 345
  start-page: 458
  year: 1990
  end-page: 460
  article-title: Telomeres shorten during ageing of human fibroblasts
  publication-title: Nature
– volume: 5
  start-page: 299
  year: 2014
  end-page: 310
  article-title: Measuring telomere length and telomere dynamics in evolutionary biology and ecology
  publication-title: Methods Ecol Evol
– volume: 95
  start-page: 10614
  year: 1998
  end-page: 10619
  article-title: Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation
  publication-title: Proc Natl Acad Sci U S A
– volume: 107
  start-page: 67
  year: 2001
  end-page: 77
  article-title: The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
  publication-title: Cell
– volume: 730
  start-page: 59
  year: 2011
  end-page: 67
  article-title: Telomere length measurement‐Caveats and a critical assessment of the available technologies and tools
  publication-title: Mutat Res
– volume: 55A
  start-page: B533
  year: 2000
  end-page: BB536
  article-title: Telomere shortening with aging in human liver
  publication-title: J Gerontol A Biol Sci
– volume: 12
  start-page: 676
  year: 2010
  end-page: 685
  article-title: The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
  publication-title: Nat Cell Biol
– volume: 37
  start-page: 67
  year: 1984
  end-page: 75
  article-title: Separation of yeast chromosome‐sized DNAs by pulsed field gradient gel electrophoresis
  publication-title: Cell
– volume: 9
  start-page: e93749
  year: 2014
  article-title: Q‐FISH measurement of hepatocyte telomere lengths in donor liver and graft after pediatric living‐donor liver transplantation: donor age affects telomere length sustainability
  publication-title: PLoS ONE
– volume: 41
  start-page: 882
  year: 2006
  end-page: 886
  article-title: Telomere shortening with aging in the human pancreas
  publication-title: Exp Gerontol
– volume: 45
  start-page: 407
  year: 2013
  end-page: 413
  article-title: Investigation of telomere length dynamics in induced pluripotent stem cells using quantitative fluorescence in situ hybridization
  publication-title: Tissue Cell
– volume: 37
  start-page: 47
  year: 2009
  end-page: 51
  article-title: Caloric restriction and aging: studies in mice and monkeys
  publication-title: Toxicol Pathol
– volume: 155
  start-page: 1104
  year: 2013
  end-page: 1118
  article-title: Programmed cell senescence during mammalian embryonic development
  publication-title: Cell
– volume: 44
  start-page: 1673
  year: 2015
  end-page: 1683
  article-title: Reproducibility of telomere length assessment – an international collaborative study
  publication-title: Int J Epidemiol
– volume: 44
  start-page: 1739
  year: 2015
  end-page: 1741
  article-title: Reproducibility of telomere length assessment: authors’ response to Damjan Krstajic and Ljubomir Buturovic
  publication-title: Int J Epidemiol
– volume: 29
  start-page: 1
  year: 2016
  end-page: 9
  article-title: Reversible transformation and de‐differentiation of human cells derived from induced pluripotent stem cell teratomas
  publication-title: Hum Cell
– volume: 42
  start-page: 944
  year: 2007
  end-page: 950
  article-title: Telomere DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older
  publication-title: Exp Gerontol
– volume: 40
  start-page: 363
  year: 2005
  end-page: 368
  article-title: New developments in telomere length analysis
  publication-title: Exp Gerontol
– volume: 37
  start-page: 523
  year: 2002
  end-page: 531
  article-title: Telomere lengths are characteristic in each human individual
  publication-title: Exp Gerontol
– volume: 46
  start-page: 470
  year: 2014
  end-page: 476
  article-title: Arm‐specific telomere dynamics of each individual chromosome in induced pluripotent stem cells revealed by quantitative fluorescence in situ hybridization
  publication-title: Tissue Cell
– volume: 33
  start-page: 171
  year: 1972
  end-page: 185
  article-title: Causes of death of alcoholics
  publication-title: Q J Stud Alcohol
– volume: 72
  start-page: 912
  year: 2000
  end-page: 921
  article-title: Prospective study of major dietary patterns and risk of coronary heart disease in men
  publication-title: Am J Clin Nutr
– volume: 45
  start-page: 473
  year: 2014
  end-page: 480
  article-title: Q‐FISH measurement of telomere length in skin with/without sun exposure or actinic keratosis
  publication-title: Hum Pathol
– volume: 225
  start-page: 951
  year: 1992
  end-page: 960
  article-title: Telomere end‐replication problem and cell aging
  publication-title: J Mol Biol
– volume: 38
  start-page: 1192
  year: 2007
  end-page: 1200
  article-title: Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method
  publication-title: Hum Pathol
– year: 2001
– volume: 349
  start-page: g6674
  year: 2014
  article-title: Mediterranean diet and telomere length in Nurses’ Health Study: population based cohort study
  publication-title: BMJ
– volume: 350
  start-page: 569
  year: 1991
  end-page: 573
  article-title: Structure and function of telomeres
  publication-title: Nature
– volume: 223
  start-page: 410
  year: 2011
  end-page: 416
  article-title: Alcoholics show reduced telomere length in the oesophagus
  publication-title: J Pathol
– volume: 347
  start-page: 78
  year: 2015
  end-page: 81
  article-title: Variation in cancer risk among tissues can be explained by the number of stem cell divisions
  publication-title: Science
– volume: 21
  start-page: 2495
  year: 2007
  end-page: 2508
  article-title: The nature of telomere fusion and a definition of the critical telomere length in human cells
  publication-title: Genes Dev
– volume: 32
  start-page: 280
  year: 2002
  end-page: 284
  article-title: Chromosomal instability in ulcerative colitis is related to telomere shortening
  publication-title: Nat Genet
– volume: 18
  start-page: 76
  year: 1998
  end-page: 80
  article-title: Short telomeres on human chromosome 17p
  publication-title: Nat Genet
– volume: 10
  start-page: e0117575
  year: 2014
  article-title: Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and without cancer in the pancreas
  publication-title: PLoS ONE
– volume: 347
  start-page: 727
  year: 2015
  publication-title: Science
– volume: 5
  start-page: 685
  year: 1996
  end-page: 691
  article-title: Heterogeneity in telomere length of human chromosomes
  publication-title: Hum Mol Genet
– volume: 97
  start-page: 750
  year: 1996
  end-page: 754
  article-title: Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells
  publication-title: Hum Genet
– volume: 221
  start-page: 201
  year: 2010
  end-page: 209
  article-title: Q‐FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ
  publication-title: J Pathol
– volume: 130
  start-page: 2949
  year: 2012
  end-page: 2960
  article-title: Development of squamous neoplasia in esophageal iodine‐unstained lesions and the alcohol and aldehyde dehydrogenase genotypes of Japanese alcoholic men
  publication-title: Int J Cancer
– volume: 22
  start-page: 38
  year: 2009
  end-page: 42
  article-title: Donor age reflects the replicative lifespan of human fibroblasts in culture
  publication-title: Hum Cell
– volume: 32
  start-page: 135
  year: 2014
  end-page: 145
  article-title: Short telomeres and chromosome instability prior to histologic malignant progression and cytogenetic aneuploidy in papillary urothelial neoplasms
  publication-title: Urol Oncol
– volume: 101
  start-page: 17312
  year: 2004
  end-page: 17315
  article-title: Accelerated telomere shortening in response to life stress
  publication-title: Proc Natl Acad Sci U S A
– volume: 27
  start-page: 339
  year: 2002
  end-page: 344
  article-title: Oxidative stress shortens telomeres
  publication-title: Trends Biochem Sci
– volume: 347
  start-page: 729
  year: 2015
  end-page: 731
  article-title: LETTERS Cancer risk: Role of environment – response
  publication-title: Science
– volume: 346
  start-page: 866
  year: 1990
  end-page: 868
  article-title: Telomere reduction in human colorectal carcinoma and with ageing
  publication-title: Nature
– volume: 7
  start-page: 877
  year: 2014
  article-title: Leukocyte telomere length variation due to DNA extraction method
  publication-title: BMC Res Notes
– volume: 31
  start-page: 1314
  year: 2001
  end-page: 1316
  article-title: Telometric: a tool providing simplified, reproducible measurements of telomeric DNA from constant field agarose gels
  publication-title: Biotechniques
– volume: 82
  start-page: 501
  year: 2008
  end-page: 509
  article-title: TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita
  publication-title: Am J Hum Genet
– volume: 361
  start-page: 393
  year: 2003
  end-page: 395
  article-title: Association between telomere length in blood and mortality in people aged 60 years or older
  publication-title: Lancet
– volume: 515
  start-page: 518
  year: 2014
  end-page: 522
  article-title: Global diets link environmental sustainability and human health
  publication-title: Nature
– volume: 95
  start-page: 5607
  year: 1998
  end-page: 5610
  article-title: The rate of telomere sequence loss in human leukocytes varies with age
  publication-title: Proc Natl Acad Sci U S A
– volume: 44
  start-page: 1683
  year: 2015
  end-page: 1686
  article-title: Commentary: the reliability of telomere length measurements
  publication-title: Int J Epidemiol
– volume: 34
  start-page: 795
  year: 2012
  end-page: 804
  article-title: Telomere dynamics in the human pituitary gland: robust preservation throughout adult life to centenarian age
  publication-title: Age (Omaha)
– volume: 37
  start-page: 614
  year: 1965
  end-page: 636
  article-title: The limited in vitro lifetime of human diploid cell strains
  publication-title: Exp Cell Res
– volume: 7
  start-page: 712
  year: 2005
  end-page: 718
  article-title: DNA processing is not required for ATM‐mediated telomere damage response after TRF2 deletion
  publication-title: Nat Cell Biol
– volume: 464
  start-page: 292
  year: 2010
  end-page: 296
  article-title: Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients
  publication-title: Nature
– volume: 533
  start-page: 199
  year: 2014
  end-page: 207
  article-title: Telomere lengths at birth in trisomy 18 and 21 measured by Q‐FISH
  publication-title: Gene
– volume: 22
  start-page: 2047
  year: 2013
  end-page: 2054
  article-title: Telomere length varies by DNA extraction method: implications for epidemiologic research
  publication-title: Cancer Epidemiol Biomarkers Prev
– volume: 41
  start-page: 372
  year: 2012
  end-page: 378
  article-title: Short telomeres in an oral precancerous lesion: Q‐FISH analysis of leukoplakia
  publication-title: J Oral Pathol Med
– volume: 18
  start-page: 18.4.1
  year: 2001
  end-page: 18.4.21
  article-title: Quantitative Fluorescence In Situ Hybridization (Q‐FISH)
  publication-title: Curr Protoc Cell Biol
– volume: 30
  start-page: e47
  year: 2002
  article-title: Telomere measurement by quantitative PCR
  publication-title: Nucleic Acids Res
– volume: 50
  start-page: 752
  year: 2009
  end-page: 762
  article-title: Large liver cell change in hepatitis B virus‐related liver cirrhosis
  publication-title: Hepatology
– volume: 39
  start-page: 1647
  year: 2008
  end-page: 1655
  article-title: Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts
  publication-title: Hum Pathol
– volume: 36
  start-page: 267
  year: 1999
  end-page: 278
  article-title: Telomere length measurements using digital fluorescence microscopy
  publication-title: Cytometry
– volume: 479
  start-page: 232
  year: 2011
  end-page: 236
  article-title: Clearance of p16Ink4a‐positive senescent cells delays ageing‐associated disorders
  publication-title: Nature
– volume: 8
  start-page: e1002696
  year: 2012
  article-title: Collapse of telomere homeostasis in hematopoietic cells caused by hetelozygous mutations in telomerase genes
  publication-title: PLoS Genet
– volume: 112
  start-page: 3594
  year: 2008
  end-page: 3600
  article-title: TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes
  publication-title: Blood
– volume: 131
  start-page: 614
  year: 2010
  end-page: 624
  article-title: Chromosomal instability and telomere lengths of each chromosomal arm measured by Q‐FISH in human fibroblast strains prior to replicative senescence
  publication-title: Mech Age Dev
– volume: 33
  start-page: 203
  year: 2003
  end-page: 207
  article-title: Extensive allelic variation and ultrrshort telomeres in senescent human cells
  publication-title: Nat Genet
– volume: 24
  start-page: 96
  year: 2011
  end-page: 103
  article-title: Establishment of human induced pluripotent stem cell lines from normal fibroblast TIG‐1
  publication-title: Hum Cell
– volume: 19
  start-page: 244
  year: 2015
  end-page: 245
  article-title: Donor age and operational tolerance in living donor liver transplantation
  publication-title: Pediatr Transplant
– volume: 8
  start-page: 167
  year: 2008
  end-page: 179
  article-title: Telomerase and cancer therapeutics
  publication-title: Nat Rev Cancer
– volume: 28
  start-page: 153
  year: 2014
  end-page: 166
  article-title: A TIN2 dyskeratosis congenita mutation causes telomerase‐independent telomere shortening in mice
  publication-title: Genes Dev
– volume: 509
  start-page: 439
  year: 2014
  end-page: 446
  article-title: The role of senescent cells in ageing
  publication-title: Nature
– volume: 23
  start-page: 86
  year: 1970
  end-page: 92
  article-title: Replicative life‐span of cultivated human cells. Effects of donor's age, tissue, and genotype
  publication-title: Lab Invest
– volume: 328
  start-page: 321
  year: 2010
  end-page: 326
  article-title: Extending healthy life span – from yeast to humans
  publication-title: Science
– volume: 15
  start-page: 121
  year: 1980
  end-page: 133
  article-title: A new human diploid cell strain, TIG‐1, for the research on cellular aging
  publication-title: Exp Gerontol
– volume: 406
  start-page: 641
  year: 2000
  end-page: 645
  article-title: Telomere dysfunction promotes non‐reciprocal translocations and epithelial cancers in mice
  publication-title: Nature
– volume: 38
  start-page: 854
  year: 2010
  end-page: 859
  article-title: Synchrony of telomere length among hematopoietic cells
  publication-title: Exp Hematol
– volume: 1
  start-page: 2365
  year: 2006
  end-page: 2376
  article-title: Flow cytometry and FISH to measure the average length of telomeres (flow FISH)
  publication-title: Nat Protoc
– ident: e_1_2_14_121_1
  doi: 10.1111/j.1749-0774.2009.00066.x
– ident: e_1_2_14_112_1
  doi: 10.1073/pnas.95.10.5607
– ident: e_1_2_14_55_1
  doi: 10.1007/s11357-011-9280-y
– ident: e_1_2_14_93_1
  doi: 10.1016/j.tice.2014.08.005
– ident: e_1_2_14_43_1
  doi: 10.1016/j.exger.2005.02.008
– ident: e_1_2_14_95_1
  doi: 10.1007/s13577‐015‐0119‐1
– ident: e_1_2_14_11_1
  doi: 10.1016/0022-2836(92)90096-3
– ident: e_1_2_14_35_1
  doi: 10.1093/nar/30.10.e47
– volume: 18
  start-page: 18.4.1
  year: 2001
  ident: e_1_2_14_40_1
  article-title: Quantitative Fluorescence In Situ Hybridization (Q‐FISH)
  publication-title: Curr Protoc Cell Biol
  contributor:
    fullname: Poon SSS
– volume: 52
  start-page: 661
  year: 1993
  ident: e_1_2_14_7_1
  article-title: Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
  publication-title: Am J Hum Genet
  contributor:
    fullname: Vaziri H
– ident: e_1_2_14_53_1
  doi: 10.1186/1756‐0500‐7‐877
– ident: e_1_2_14_117_1
  doi: 10.1038/nature13959
– ident: e_1_2_14_18_1
  doi: 10.1016/j.cell.2013.10.041
– ident: e_1_2_14_49_1
  doi: 10.1093/ije/dyv166
– ident: e_1_2_14_5_1
  doi: 10.1152/physrev.00026.2007
– ident: e_1_2_14_30_1
  doi: 10.1016/j.mad.2010.08.007
– ident: e_1_2_14_109_1
  doi: 10.1126/science.aaa6246
– ident: e_1_2_14_110_1
  doi: 10.1126/science.aaa6592
– ident: e_1_2_14_8_1
  doi: 10.1111/j.1447-0594.2010.00605.x
– volume: 23
  start-page: 86
  year: 1970
  ident: e_1_2_14_119_1
  article-title: Replicative life‐span of cultivated human cells. Effects of donor's age, tissue, and genotype
  publication-title: Lab Invest
  contributor:
    fullname: Martin GM
– ident: e_1_2_14_24_1
  doi: 10.18632/aging.100315
– start-page: 21
  volume-title: Telomeres
  year: 2006
  ident: e_1_2_14_83_1
  contributor:
    fullname: Cristofari G
– ident: e_1_2_14_115_1
  doi: 10.1126/science.1172539
– ident: e_1_2_14_103_1
  doi: 10.1016/S0968-0004(02)02110-2
– ident: e_1_2_14_28_1
  doi: 10.1371/journal.pone.0063860
– ident: e_1_2_14_12_1
  doi: 10.1006/excr.1995.1306
– ident: e_1_2_14_85_1
  doi: 10.1111/j.1365‐2141.2009.07598.x
– ident: e_1_2_14_96_1
  doi: 10.1101/gad.1346005
– ident: e_1_2_14_113_1
  doi: 10.1111/petr.12431
– ident: e_1_2_14_34_1
  doi: 10.1038/nprot.2010.124
– ident: e_1_2_14_78_1
  doi: 10.0116/j.humpath.2008.04.005
– ident: e_1_2_14_39_1
  doi: 10.1002/(SICI)1097-0320(19990801)36:4<267::AID-CYTO1>3.0.CO;2-O
– ident: e_1_2_14_44_1
  doi: 10.1016/j.mrfmmm.2011.04.003
– ident: e_1_2_14_75_1
  doi: 10.1007/s00268-012-1453-z
– ident: e_1_2_14_100_1
  doi: 10.1016/S0092-8674(00)80932-0
– ident: e_1_2_14_38_1
  doi: 10.1093/hmg/5.5.685
– ident: e_1_2_14_70_1
  doi: 10.1111/j.1600-0714.2011.01120.x
– ident: e_1_2_14_67_1
  doi: 10.1016/j.humpath.2006.11.023
– ident: e_1_2_14_15_1
  doi: 10.1016/S0092-8674(01)00504-9
– ident: e_1_2_14_65_1
  doi: 10.1158/1078-0432.CCR-0984-03
– ident: e_1_2_14_74_1
  doi: 10.1016/j.exger.2006.06.036
– ident: e_1_2_14_102_1
  doi: 10.1038/nature14513
– ident: e_1_2_14_36_1
  doi: 10.1093/nar/gkn1027
– ident: e_1_2_14_81_1
  doi: 10.1016/j.exger.2007.05.003
– ident: e_1_2_14_27_1
  doi: 10.1002/path.2817
– ident: e_1_2_14_105_1
  doi: 10.15288/qjsa.1972.33.171
– ident: e_1_2_14_80_1
  doi: 10.1016/S0140-6736(03)12384-7
– ident: e_1_2_14_87_1
  doi: 10.1042/CBI20110460
– ident: e_1_2_14_120_1
  doi: 10.1073/pnas.95.18.10614
– ident: e_1_2_14_10_1
  doi: 10.1016/0014-4827(65)90211-9
– ident: e_1_2_14_90_1
  doi: 10.1038/nature08792
– ident: e_1_2_14_104_1
  doi: 10.1073/pnas.0407162101
– ident: e_1_2_14_89_1
  doi: 10.1007/s13577‐011‐0016‐1
– ident: e_1_2_14_66_1
  doi: 10.1002/hep.23072
– ident: e_1_2_14_69_1
  doi: 10.1016/j.ejca.2009.10.018
– ident: e_1_2_14_20_1
  doi: 10.1016/j.cell.2008.06.049
– ident: e_1_2_14_71_1
  doi: 10.1080/00365520902718705
– ident: e_1_2_14_58_1
  doi: 10.2144/01316bc02
– ident: e_1_2_14_68_1
  doi: 10.1016/j.exger.2008.06.001
– ident: e_1_2_14_13_1
  doi: 10.1038/35020592
– ident: e_1_2_14_77_1
  doi: 10.1016/0531-5565(80)90083-2
– ident: e_1_2_14_88_1
  doi: 10.1016/j.cell.2006.07.024
– volume-title: Molecular Cloning: A Laboratory Manual
  year: 2001
  ident: e_1_2_14_32_1
  contributor:
    fullname: Sambrook J
– ident: e_1_2_14_42_1
  doi: 10.1371/journal.pgen.1002696
– ident: e_1_2_14_25_1
  doi: 10.1210/jc.2014-1222
– ident: e_1_2_14_50_1
  doi: 10.1093/ije/dyv169
– ident: e_1_2_14_51_1
  doi: 10.1016/0092-8674(84)90301-5
– ident: e_1_2_14_54_1
  doi: 10.1046/j.1523-1747.2002.19523.x
– ident: e_1_2_14_97_1
  doi: 10.1016/j.ajhg.2007.10.004
– ident: e_1_2_14_108_1
  doi: 10.1126/science.1260825
– ident: e_1_2_14_116_1
  doi: 10.1093/ajcn/72.4.912
– ident: e_1_2_14_57_1
  doi: 10.1093/gerona/55.11.B533
– ident: e_1_2_14_56_1
  doi: 10.1007/s11357-999-0011-6
– ident: e_1_2_14_82_1
  doi: 10.1016/j.mad.2007.10.009
– ident: e_1_2_14_114_1
  doi: 10.1177/0192623308329476
– ident: e_1_2_14_26_1
  doi: 10.1371/journal.pone.0093749
– ident: e_1_2_14_47_1
  doi: 10.1093/ije/dyv167
– ident: e_1_2_14_23_1
  doi: 10.4236/ajac.2014.512086
– ident: e_1_2_14_45_1
  doi: 10.1111/2041-210X.12161
– ident: e_1_2_14_94_1
  doi: 10.1016/j.tice.2013.07.003
– ident: e_1_2_14_73_1
  doi: 10.1371/journal.pone.0117575
– ident: e_1_2_14_62_1
  doi: 10.1016/j.exphem.2010.06.010
– ident: e_1_2_14_72_1
  doi: 10.1002/path.2704
– ident: e_1_2_14_31_1
  doi: 10.1016/j.urolonc.2012.12.005
– ident: e_1_2_14_19_1
  doi: 10.1038/ncb2070
– ident: e_1_2_14_111_1
  doi: 10.1038/517563a
– ident: e_1_2_14_61_1
  doi: 10.1016/S0531-5565(01)00218-2
– ident: e_1_2_14_76_1
  doi: 10.1016/j.gene.2013.09.086
– ident: e_1_2_14_86_1
  doi: 10.1126/science.279.5349.349
– ident: e_1_2_14_106_1
  doi: 10.1002/ijc.26296
– ident: e_1_2_14_48_1
  doi: 10.1093/ije/dyv170
– ident: e_1_2_14_52_1
  doi: 10.1158/1055‐9965.EPI‐13‐0409
– ident: e_1_2_14_91_1
  doi: 10.1038/nature10084
– ident: e_1_2_14_60_1
  doi: 10.1038/srep02401
– ident: e_1_2_14_64_1
  doi: 10.1038/ng989
– ident: e_1_2_14_107_1
  doi: 10.1007/BF02346184
– ident: e_1_2_14_41_1
  doi: 10.1038/nprot.2006.263
– ident: e_1_2_14_17_1
  doi: 10.1016/j.cell.2013.10.019
– ident: e_1_2_14_92_1
  doi: 10.1038/cr.2011.120
– ident: e_1_2_14_59_1
  doi: 10.1038/hdy.2011.10
– ident: e_1_2_14_14_1
  doi: 10.1146/annurev-physiol-030212-183653
– ident: e_1_2_14_29_1
  doi: 10.1016/j.humpath.2013.10.009
– ident: e_1_2_14_16_1
  doi: 10.1101/gad.439107
– ident: e_1_2_14_37_1
  doi: 10.1038/ng1084
– ident: e_1_2_14_79_1
  doi: 10.1038/nrc2275
– ident: e_1_2_14_98_1
  doi: 10.1182/blood‐2008‐05‐153445
– ident: e_1_2_14_46_1
  doi: 10.1093/ije/dyv191
– ident: e_1_2_14_3_1
  doi: 10.1073/pnas.85.18.6622
– start-page: 49
  volume-title: Telomeres
  year: 2006
  ident: e_1_2_14_84_1
  contributor:
    fullname: Chen J‐L
– ident: e_1_2_14_99_1
  doi: 10.1101/gad.233395.113
– ident: e_1_2_14_4_1
  doi: 10.1038/nature02118
– ident: e_1_2_14_22_1
  doi: 10.1038/nature13193
– ident: e_1_2_14_9_1
  doi: 10.1016/0014-4827(61)90192-6
– ident: e_1_2_14_63_1
  doi: 10.1038/ng0198-018
– ident: e_1_2_14_6_1
  doi: 10.1038/345458a0
– ident: e_1_2_14_33_1
  doi: 10.1038/346866a0
– ident: e_1_2_14_118_1
  doi: 10.1136/bmj.g6674
– ident: e_1_2_14_21_1
  doi: 10.1038/nature10600
– ident: e_1_2_14_101_1
  doi: 10.1038/ncb1275
– ident: e_1_2_14_2_1
  doi: 10.1038/350569a0
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Snippet Accumulated data have shown that most human somatic cells or tissues show irreversible telomere shortening with age, and that there are strong associations...
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SubjectTerms Aging
Aging - genetics
Blotting, Southern
Chromosomes
Gerontology
Humans
In Situ Hybridization, Fluorescence
precancerous states
quantitative fluorescence in situ hybridization
replicative senescence
telomere
Telomere - physiology
Telomere Homeostasis - physiology
terminal restriction fragment
Title Changes of telomere status with aging: An update
URI https://api.istex.fr/ark:/67375/WNG-4JVM5TQZ-H/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fggi.12772
https://www.ncbi.nlm.nih.gov/pubmed/27018281
https://www.proquest.com/docview/1776049151
https://search.proquest.com/docview/1776629669
Volume 16
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