Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization

• Published in: Circulation (New York, N.Y.) Vol. 135; no. 8; pp. 741 - 754
• Main Authors: Chatterjee, Neal A., Giulianini, Franco, Geelhoed, Bastiaan, Lunetta, Kathryn L., Misialek, Jeffrey R., Niemeijer, Maartje N., Rienstra, Michiel, Rose, Lynda M., Smith, Albert V., Arking, Dan E., Ellinor, Patrick T., Heeringa, Jan, Lin, Honghuang, Lubitz, Steven A., Soliman, Elsayed Z., Verweij, Niek, Alonso, Alvaro, Benjamin, Emelia J., Gudnason, Vilmundur, Stricker, Bruno H. C., Van Der Harst, Pim, Chasman, Daniel I., Albert, Christine M.
• Format: Journal Article
• Language: English
• Published: United States by the American College of Cardiology Foundation and the American Heart Association, Inc 21.02.2017
• Subjects: Aged; Alleles; Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics; Atrial Fibrillation - epidemiology; Atrial Fibrillation - etiology; Body Mass Index; Cohort Studies; Female; Genotype; Humans; Incidence; Male; Middle Aged; Obesity - genetics; Obesity - pathology; Polymorphism, Single Nucleotide; Proportional Hazards Models; Prospective Studies; Random Allocation; Risk Factors; epidemiology; atrial fibrillation; genetics; prevention & control; obesity

BACKGROUND:Observational studies have identified an association between body mass index (BMI) and incident atrial fibrillation (AF). Inferring causality from observational studies, however, is subject to residual confounding, reverse causation, and bias. The primary objective of this study was to ev...