Opposite Predictive Value of Pulse Pressure and Aortic Pulse Wave Velocity on Heart Failure With Reduced Left Ventricular Ejection Fraction: Insights From an Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) Substudy

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 63; no. 1; pp. 105 - 111
• Main Authors: Regnault, Veronique, Lagrange, Jérémy, Pizard, Anne, Safar, Michel E., Fay, Renaud, Pitt, Bertram, Challande, Pascal, Rossignol, Patrick, Zannad, Faiez, Lacolley, Patrick
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 01.01.2014; Lippincott Williams & Wilkins; American Heart Association
• Subjects: Acoustics; Aged; Arterial hypertension. Arterial hypotension; Arterial Pressure; Biological and medical sciences; Biomechanics; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular system; Coronary heart disease; Female; Heart; Heart Failure - diagnosis; Heart Failure - etiology; Heart Failure - mortality; Heart Failure - physiopathology; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Humans; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Male; Mechanics; Medical sciences; Middle Aged; Mineralocorticoid Receptor Antagonists - therapeutic use; Myocardial Infarction - complications; Physics; Predictive Value of Tests; Prognosis; Pulse Wave Analysis; Spironolactone - analogs & derivatives; Spironolactone - therapeutic use; Stroke Volume; Ventricular Dysfunction, Left - diagnosis; Ventricular Dysfunction, Left - etiology; Ventricular Dysfunction, Left - mortality; Ventricular Dysfunction, Left - physiopathology; Myocardial infarction; Prognosis; Mineralocorticoid; Cardiovascular disease; Arterial pulse; Aldosterone; Myocardial disease; Knowledge; Reduction; Pulsed pressure; Efficiency; Blood vessel; pulse wave analysis; Predictive value; Aorta; Arterial pressure; Ventricular ejection; Blood pressure; Stiffness; Cardiology; Hypertension; Heart failure; Steroid hormone; Acute; vascular stiffness; Coronary heart disease; Survival; Artery; Left ventricle; Aldosterone antagonist; Eplerenone; Analysis; Adrenal hormone; ventricular ejection fraction; Antihypertensive agent; Hemodynamics; Circulatory system; Ejection fraction; blood pressure; heart failure; hypertension

Although hypertension contributes significantly to worsen cardiovascular risk, blood pressure increment in subjects with heart failure is paradoxically associated with lower risk. The objective was to determine whether pulse pressure and pulse wave velocity (PWV) remain prognostic markers, independe...