Growth factor therapy for cardiac repair: an overview of recent advances and future directions

• Published in: Biophysical reviews Vol. 12; no. 4; pp. 805 - 815
• Main Authors: White, Samuel J., Chong, James J. H.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2020; Springer Nature B.V
• Subjects: Angiogenesis; Apoptosis; Biochemistry; Biological and Medical Physics; Biological Techniques; Biomedical and Life Sciences; Biophysics; Cardiomyopathy; Cell Biology; Cell therapy; Chemical compounds; Clinical trials; Congestive heart failure; Coronary artery disease; Fibrosis; Growth factors; Heart diseases; Insulin; Insulin-like growth factor I; Insulin-like growth factors; Life Sciences; Membrane Biology; Morbidity; Myocardial infarction; Nanotechnology; Neuregulin; Pharmacology; Platelet-derived growth factor; Public health; Restoration; Review; Neuregulin; Cardiac repair; Platelet-derived growth factor; Insulin-like growth factor 1; Growth factor

Heart disease represents a significant public health burden and is associated with considerable morbidity and mortality at the level of the individual. Current therapies for pathologies such as myocardial infarction, cardiomyopathy and heart failure are unable to repair damaged tissue to an extent t...