Second line therapy: type 2 diabetic subjects failing on metformin GLP-1/DPP-IV inhibitors versus sulphonylurea/insulin: For GLP-1/DPP-IV inhibitors

• Published in: Diabetes/metabolism research and reviews Vol. 28; no. s2; pp. 21 - 25
• Main Author: Kumar, Ajay
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2012; Wiley Subscription Services, Inc
• Subjects: Diabetes; Diabetes Mellitus, Type 2 - drug therapy; Dipeptidyl-Peptidase IV Inhibitors - therapeutic use; GLP-1; Glucagon-Like Peptide 1 - antagonists & inhibitors; Humans; Hypoglycemic Agents - therapeutic use; Incretins; Insulin; Insulin - therapeutic use; Medical research; Metformin - therapeutic use; Retreatment; Sulfonylurea Compounds - therapeutic use; Treatment Failure; Type 2 diabetes

Summary Following diagnosis, type 2 diabetic subjects are invariably treated with life style modifications and metformin. However, majority of these subjects require addition of another therapeutic agent singly or in combination; with or without insulin within few months to few years. For several de...