DNA perspectives of fixed and paraffin embedded human tissues as resource materials for the identification
In addition to the diagnostic and therapeutic use of excised human tissues in fixatives, the fixed tissues represent an invaluable resource that provide an incredible opportunity for the assessment of genetic studies in situations where subjects are no longer alive. Purposely the fixation serves to...
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| Published in | Egyptian journal of forensic sciences Vol. 7; no. 1; pp. 1 - 7 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.12.2017
Springer Nature B.V SpringerOpen |
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| Abstract | In addition to the diagnostic and therapeutic use of excised human tissues in fixatives, the fixed tissues represent an invaluable resource that provide an incredible opportunity for the assessment of genetic studies in situations where subjects are no longer alive. Purposely the fixation serves to prevent the cellular changes as well as a resistance to cellular alterations that occur due to abrupt ligation of circulation during excision. Importantly DNA extracted from these tissues can be used in the identification of a person such as in cases of paternity testing, abduction or soldier missing in action, in crime cases where biological evidence is available for comparison, identifying mismatched specimens for re-evaluation and more outstandingly in insurance cases. However, the DNA recovery from these samples along with its amplification is a challenging task due to various factors thereby limiting the use of these preserved specimens for forensic DNA related investigations. In order to clarify various doubtful reproaches in different cases where justice had to be done from the challenging samples of fixed specimens, the present paper aimed not only on the issues concerning with these invaluable specimens, but also on varied interesting nature of case reports so that better discrimination is achieved in the areas of concern. |
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| AbstractList | In addition to the diagnostic and therapeutic use of excised human tissues in fixatives, the fixed tissues represent an invaluable resource that provide an incredible opportunity for the assessment of genetic studies in situations where subjects are no longer alive. Purposely the fixation serves to prevent the cellular changes as well as a resistance to cellular alterations that occur due to abrupt ligation of circulation during excision. Importantly DNA extracted from these tissues can be used in the identification of a person such as in cases of paternity testing, abduction or soldier missing in action, in crime cases where biological evidence is available for comparison, identifying mismatched specimens for re-evaluation and more outstandingly in insurance cases. However, the DNA recovery from these samples along with its amplification is a challenging task due to various factors thereby limiting the use of these preserved specimens for forensic DNA related investigations. In order to clarify various doubtful reproaches in different cases where justice had to be done from the challenging samples of fixed specimens, the present paper aimed not only on the issues concerning with these invaluable specimens, but also on varied interesting nature of case reports so that better discrimination is achieved in the areas of concern. Abstract In addition to the diagnostic and therapeutic use of excised human tissues in fixatives, the fixed tissues represent an invaluable resource that provide an incredible opportunity for the assessment of genetic studies in situations where subjects are no longer alive. Purposely the fixation serves to prevent the cellular changes as well as a resistance to cellular alterations that occur due to abrupt ligation of circulation during excision. Importantly DNA extracted from these tissues can be used in the identification of a person such as in cases of paternity testing, abduction or soldier missing in action, in crime cases where biological evidence is available for comparison, identifying mismatched specimens for re-evaluation and more outstandingly in insurance cases. However, the DNA recovery from these samples along with its amplification is a challenging task due to various factors thereby limiting the use of these preserved specimens for forensic DNA related investigations. In order to clarify various doubtful reproaches in different cases where justice had to be done from the challenging samples of fixed specimens, the present paper aimed not only on the issues concerning with these invaluable specimens, but also on varied interesting nature of case reports so that better discrimination is achieved in the areas of concern. |
| ArticleNumber | 23 |
| Author | Noor, Farida Ullah, Sami Garg, Rakesh K. |
| Author_xml | – sequence: 1 givenname: Sami surname: Ullah fullname: Ullah, Sami organization: Department of Forensic Science, Punjabi University – sequence: 2 givenname: Rakesh K. surname: Garg fullname: Garg, Rakesh K. email: rkgvpbi11@yahoo.com organization: Department of Forensic Science, Punjabi University – sequence: 3 givenname: Farida surname: Noor fullname: Noor, Farida organization: Department of Forensic Medicine & Toxicology, Government Medical College |
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| Cites_doi | 10.1016/j.fsigss.2009.08.059 10.1016/j.fsigss.2009.08.019 10.1016/j.ics.2005.09.018 10.1016/S0379-0738(00)00241-3 10.1158/1538-7445.AM2014-4286 10.1309/MGW2XKFT0NYQCUHW 10.1371/journal.pone.0000537 10.1016/j.fsigen.2009.06.010 10.1016/S0379-0738(96)02096-8 10.1016/j.forsciint.2009.09.004 10.3325/cmj.2011.52.410 10.1016/j.forsciint.2003.10.016 10.1016/j.jacc.2003.11.052 10.1016/j.fsigen.2007.06.006 10.1016/j.legalmed.2015.03.005 10.1016/S0531-5131(02)00500-9 10.1038/318577a0 10.1097/MCG.0b013e3182688a6e 10.1016/j.scijus.2010.09.001 10.3325/cmj.2009.50.218 10.1016/j.forsciint.2004.03.006 10.1111/j.1556-4029.2005.00013.x 10.1520/JFS14188J 10.1016/j.ijcard.2007.05.001 10.1111/j.1556-4029.2009.01046.x 10.1007/BF01225493 10.1080/00313020701329757 10.1038/448959a 10.1186/1756-0500-3-239 10.3791/2763 |
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| SubjectTerms | Deoxyribonucleic acid DNA DNA analysis Fixation Forensic Forensic Medicine Formalin fixed samples Medicine Medicine & Public Health Paraffin-embedded tissues Pathology Review |
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| Title | DNA perspectives of fixed and paraffin embedded human tissues as resource materials for the identification |
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