IxsS7: A novel biomarker for Ixodes scapularis tick bite exposure in humans

• Published in: Ticks and tick-borne diseases Vol. 16; no. 4; p. 102514
• Main Authors: Kelly, Patrick H., Cummings, Derek A.T., Iniguez, Eva, Donatelli, Tiago, Rogerio, Luana, Kotál, Jan, Martins, Larissa Almeida, Berger, Markus, Sousa-Paula, Lucas C, Lu, Stephen, Stark, James H., Ng, Siu-Ping, Marques, Adriana, Valenzuela, Jesus G., Tirloni, Lucas
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier GmbH 01.07.2025; Elsevier
• Subjects: Animals; Arthropod Proteins - genetics; Arthropod Proteins - immunology; Biomarkers - blood; Borrelia; Female; Humans; Ixodes; Ixodes - genetics; Ixodid; Lyme; Male; Salivary Proteins and Peptides - genetics; Salivary Proteins and Peptides - immunology; Tick; Tick Bites - diagnosis; Tick saliva; Vaccine; Lyme; Ixodes; Borrelia; Tick saliva; Tick; Vaccine; Ixodid

•IxsS7 is a novel antigenic biomarker of I. scapularis exposure in humans.•IxsS7 protein coding sequence is highly conserved in Ixodes ticks.•Sera from recombinant (r) IxsS7 immunized rabbits recognizes I. scapularis versus other genera.•rIxsS7 is recognized by IgG from humans who self-report prior...