Per- and polyfluoroalkyl substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids

• Published in: Toxicological sciences Vol. 194; no. 1; pp. 38 - 52
• Main Authors: Addicks, Gregory C, Rowan-Carroll, Andrea, Reardon, Anthony J F, Leingartner, Karen, Williams, Andrew, Meier, Matthew J, Moffat, Ivy, Carrier, Richard, Lorusso, Luigi, Wetmore, Barbara A, Yauk, Carole L, Atlas, Ella
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 28.06.2023
• Subjects: Emerging Technologies, Methods, and Models; liver spheroids; benchmark concentration; mixture toxicity; new approach methodology; TempO-Seq; PFAS

Abstract Per- and polyfluoroalkyl substances (PFAS) are a wide range of chemicals that are used in a variety of consumer and industrial products leading to direct human exposure. Many PFAS are chemically nonreactive and persistent in the environment, resulting in additional exposure from water, soil...