The role of renin-angiotensin aldosterone system related micro-ribonucleic acids in hypertension

Micro-ribonucleic acids (miRNAs) are small (21-25 nucleotide) single-stranded, evolutionarily conserved non-protein-coding RNAs, which control diverse cellular functions by interacting with the 3' untranslated region of specific target messenger RNAs at the post-transcriptional level. Research...

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Bibliographic Details
Published inSaudi medical journal Vol. 36; no. 10; pp. 1151 - 1155
Main Authors Wang, Hui-Bo, Yang, Jun
Format Journal Article
LanguageEnglish
Published Saudi Arabia Saudi Medical Journal 01.10.2015
Subjects
Aldosterone
Angiotensins
Glucocorticoids
Humans
Hypertension
Hypertension - genetics
Hypertension - metabolism
MicroRNA
MicroRNAs - metabolism
Renin-Angiotensin System - genetics
Review
Steroids (Organic compounds)
Transcription (Genetics)
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Summary:Micro-ribonucleic acids (miRNAs) are small (21-25 nucleotide) single-stranded, evolutionarily conserved non-protein-coding RNAs, which control diverse cellular functions by interacting with the 3' untranslated region of specific target messenger RNAs at the post-transcriptional level. Research shows that an aberrant expression profile of miRNAs has been linked to a series of diseases, including hypertension. In the past few decades, it has been demonstrated that excessive activation of the renin-angiotensin aldosterone system (RAAS) involves in the pathogenesis of hypertension. This article reviews the latest insights in the identification of RAAS-correlative miRNAs and the potential mechanisms for their roles in hypertension.
ISSN:0379-5284
1658-3175
DOI:10.15537/smj.2015.10.12458