Developmental origins of Parkinson’s disease risk: perinatal exposure to the organochlorine pesticide dieldrin leads to sex-specific DNA modifications in critical neurodevelopmental pathways in the mouse midbrain

• Published in: Toxicological sciences Vol. 201; no. 2; pp. 263 - 281
• Main Authors: Kochmanski, Joseph, Virani, Mahek, Kuhn, Nathan C, Boyd, Sierra L, Becker, Katelyn, Adams, Marie, Bernstein, Alison I
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.10.2024
• Subjects: Animals; Dieldrin - toxicity; Dopaminergic Neurons - drug effects; Dopaminergic Neurons - pathology; Female; Male; Mesencephalon - drug effects; Mesencephalon - metabolism; Mice; Mice, Inbred C57BL; Neurotoxicology; Pesticides - toxicity; Pregnancy; Prenatal Exposure Delayed Effects - chemically induced; Sex Factors; DNA methylation; dieldrin; pesticides; epigenetics; Parkinson’s disease

Epidemiological studies show that exposure to the organochlorine pesticide dieldrin is associated with an increased risk of Parkinson’s disease (PD). Animal studies support a link between developmental dieldrin exposure and increased neuronal susceptibility in the α-synuclein preformed fibril and MP...