Polystyrene nanoplastics induced transgenerational reproductive toxicity in Caenorhabditis elegans through enhanced DNA damage accompanied by DNA repair inhibition

• Published in: Ecotoxicology and environmental safety Vol. 301; p. 118500
• Main Authors: Li, Fanghao, Xu, Xinran, Wang, Zhiyuan, Xie, Jianjun, Wei, Siyang, Ji, Zhenglei, Liu, Lu, Wu, Huazhang, Zhao, Yunli
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.08.2025; Elsevier
• Subjects: Animals; Apoptosis - drug effects; Caenorhabditis elegans; Caenorhabditis elegans - drug effects; Caenorhabditis elegans - genetics; Caenorhabditis elegans - physiology; Caenorhabditis elegans Proteins - genetics; Caenorhabditis elegans Proteins - metabolism; DNA damage; DNA Damage - drug effects; DNA repair; DNA Repair - drug effects; Environmental Pollutants - toxicity; Microplastics - toxicity; Nanoparticles - toxicity; Polystyrene nanoplastics (PS-NPs); Polystyrenes - toxicity; Reproduction - drug effects; Transgenerational reproductive toxicity; Transgenerational reproductive toxicity; Caenorhabditis elegans; Polystyrene nanoplastics (PS-NPs); DNA repair; DNA damage

Microplastics (MPs) are omnipresent environmental pollutants posing potential impacts on organisms. To explore the transgenerational effects of polystyrene nanoplastics (PS-NPs) and the molecular mechanisms at environmental relevant concentrations, Caenorhabditis elegans (C.elegans) was applied as a...