A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer's disease

• Published in: Experimental gerontology Vol. 107; pp. 18 - 26
• Main Authors: Croteau, E., Castellano, C.A., Fortier, M., Bocti, C., Fulop, T., Paquet, N., Cunnane, S.C.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.07.2018
• Subjects: Acetoacetate; Acetoacetates - metabolism; Aged; Aged, 80 and over; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - metabolism; Alzheimer's disease (AD); Brain - diagnostic imaging; Brain - metabolism; Case-Control Studies; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - metabolism; Cross-Sectional Studies; Energy Metabolism; Female; Fluorodeoxyglucose F18; Glucose; Glucose - metabolism; Humans; Ketones; Linear Models; Magnetic Resonance Imaging; Male; Mild cognitive impairment (MCI); Positron-Emission Tomography; Alzheimer's disease (AD); Glucose; Ketones; Brain metabolism; Mild cognitive impairment (MCI); Acetoacetate

Deteriorating brain glucose metabolism precedes the clinical onset of Alzheimer's disease (AD) and appears to contribute to its etiology. Ketone bodies, mainly β-hydroxybutyrate and acetoacetate, are the primary alternative brain fuel to glucose. Some reports suggest that brain ketone metabolis...