Ambient fine particulate matter induces cardiac fibrosis through triggering ferroptosis by heme degradation induced-iron overload - Jiang, Jinjin; Li, Yang; Chen, Yuping; Wu, Qin; Ding, Shibin (Ecotoxicology and environmental safety, 2025)
Keywords: Air Pollutants - toxicity; Animals; Cardiac fibrosis; Ferroptosis; Ferroptosis - drug effects; Fibrosis - chemically induced; Fine particulate matter; Heme - metabolism; Heme oxygenase-1; Iron overload; Iron Overload - chemically induced; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac - drug effects; Particulate Matter - toxicity; Iron overload; GPX4; Heme oxygenase-1; Ferroptosis; HO-1; ACSL4; Cardiac fibrosis; Fine particulate matter; 4-HNE; Nrf2; PM2.5; ROS; Keap1; PM; Fer-1