The APTT response of pregnant plasma to unfractionated heparin

• Published in: Thrombosis and haemostasis Vol. 87; no. 1; p. 92
• Main Authors: Chunilal, S D, Young, E, Johnston, M A, Robertson, C, Naguit, I, Stevens, P, Galashan, D, Oskamp, M L, Brennan, B, Ginsberg, J S
• Format: Journal Article
• Language: English
• Published: Germany 01.01.2002
• Subjects: Adult; Anticoagulants - administration & dosage; Anticoagulants - pharmacology; Antigens - blood; Blood Coagulation - drug effects; Factor VIII - analysis; Factor Xa Inhibitors; Female; Heparin - administration & dosage; Heparin - pharmacology; Humans; Partial Thromboplastin Time; Pregnancy; Pregnancy Trimester, Third - blood; Reference Values; von Willebrand Factor - immunology
• ISSN: 0340-6245
• DOI: 10.1055/s-0037-1612949

Pregnancy is associated with a physiological increase in coagulation factors and heparin binding proteins; both can affect the activated partial thromboplastin time (APTT) in response to unfractionated heparin (UFH) invalidating the use of a non-pregnant APTT therapeutic range. We compared the antic...