Essential Role of CCR2 in Neutrophil Tissue Infiltration and Multiple Organ Dysfunction in Sepsis

• Published in: American journal of respiratory and critical care medicine Vol. 183; no. 2; pp. 234 - 242
• Main Authors: SOUTO, Fabricio O, ALVES, José C, TURATO, Walter M, AUXILIADORA-MARTINS, Maria, BASILE, Anibal, CUNHA, Fernando Q
• Format: Journal Article
• Language: English
• Published: New York, NY American Thoracic Society 15.01.2011
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Biological and medical sciences; Biomarkers - blood; Chemokines; Chemotaxis; Disease Models, Animal; Emergency and intensive care: infection, septic shock; Enzyme-Linked Immunosorbent Assay - methods; Flow Cytometry - methods; Humans; Infections; Intensive care medicine; Ligands; Medical sciences; Mice; Mice, Inbred C57BL; Multiple organ dysfunction syndrome; Multiple Organ Failure - blood; Multiple Organ Failure - etiology; Neutrophils; Neutrophils - metabolism; Peroxidase - blood; Receptors, CCR2 - blood; Sepsis; Severity of Illness Index; Shock, Septic - blood; Shock, Septic - complications; Up-Regulation; Brazil; Infection; Sepsis syndrome; Intensive care; Infiltration; Chemokine receptor; CC chemokine; Neutrophil; neutrophils; Resuscitation; multiple organ dysfunction syndrome; sepsis; CCR2

Sepsis is defined as a systemic inflammatory response to infection, which in its severe form is associated with multiple organ dysfunction syndrome (MODS). The precise mechanisms by which MODS develops remain unclear. Neutrophils have a pivotal role in the defense against infections; however, overwh...