A New Long-Acting Injectable Microcapsule System for the Administration of Progesterone

• Published in: Fertility and sterility Vol. 31; no. 5; pp. 545 - 551
• Main Authors: Beck, Lee R., Cowsar, Donald R., Lewis, Danny H., Cosgrove, Robert J., Riddle, Charles T., Lowry, Suzanne L., Epperly, Thomas
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.1979
• Subjects: Animals; Contraceptive Agents - administration & dosage; Delayed-Action Preparations; Drug Evaluation, Preclinical; Female; Injections, Intramuscular; Lactates; Microspheres; Papio; Polymers; Population; Progesterone - administration & dosage; Rats; Progestational Hormones; Contraceptive Agents, Progestin; In Vitro; Biology; Contraception; Hormones; Family Planning; Research Methodology; Endocrine System; Biodegradable Delivery Systems; Progesterone > administraction and dosage; Clinical Research; Contraceptive Methods; Injectables; Physiology; Animals, Laboratory

A long-acting injectable microcapsule system for the controlled-release systemic administration of progesterone (P4) is described. The system consists of microcapsules made of the biodegradable polymer, d,l-polylactic acid, which contain crystalline P4. Following injection, P4 is released from the m...