Role of D-galactose-induced brain aging and its potential used for therapeutic interventions

• Published in: Experimental gerontology Vol. 101; pp. 13 - 36
• Main Authors: Shwe, Thazin, Pratchayasakul, Wasana, Chattipakorn, Nipon, Chattipakorn, Siriporn C.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.01.2018
• Subjects: Aging - metabolism; Brain - metabolism; Brain aging; Cellular Senescence - drug effects; Cellular Senescence - physiology; Cognition - physiology; Cognitive function; D-galactose; Dementia - metabolism; Drug Discovery - methods; Galactose - metabolism; Humans; Mitochondria; Mitochondria - physiology; Models, Animal; Therapeutic; Brain aging; Therapeutic; Mitochondria; D-galactose; Cognitive function

Aging is a phenomenon that all living organisms inevitably face. Every year, 9.9million people, globally, suffer from dementia, an indicator of the aging brain. Brain aging is significantly associated with mitochondrial dysfunction. This is characterized by a decrease in the activity of respiratory...