Endoplasmic Reticulum Oxidative Stress Promotes Glutathione-Dependent Oxidation of Collagen-1A1 and Promotes Lung Fibroblast Activation - Druso, Joseph E.; MacPherson, Maximilian B.; Chia, Shi B.; Elko, Evan; Aboushousha, Reem; Seward, David J.; Abdelhamid, Hend; Erickson, Cuixia; Corteselli, Elizabeth; Tarte, Megan; Peng, Zhihua; Bernier, Daniel; et al. (American journal of respiratory cell and molecular biology, 2024)
Keywords: Collagen (type I); Collagen Type I - metabolism; Collagen Type I, alpha 1 Chain; Collagenase; Endoplasmic reticulum; Endoplasmic Reticulum - metabolism; Endoplasmic Reticulum Stress; Extracellular matrix; Fibroblasts - metabolism; Fibrosis; Glutaredoxin; Glutaredoxins - genetics; Glutaredoxins - metabolism; Glutathione; Glutathione - metabolism; Humans; Idiopathic Pulmonary Fibrosis - metabolism; Idiopathic Pulmonary Fibrosis - pathology; Lung - metabolism; Lung - pathology; Lung diseases; Membrane Glycoproteins; Original Research; Oxidation-Reduction; Oxidative Stress; Oxidoreductases - genetics; Oxidoreductases - metabolism; Peroxiredoxins; Pulmonary fibrosis; Transcription activation; Transforming Growth Factor beta1 - metabolism; Transforming growth factor-b1; mechanosensing; idiopathic pulmonary fibrosis; glutaredoxin; glutathionylation; redox