Myocyte cellular hypertrophy is responsible for ventricular remodelling in the hypertrophied heart of middle aged individuals in the absence of cardiac failure

• Published in: Cardiovascular research Vol. 28; no. 8; pp. 1199 - 1208
• Main Authors: Olivetti, Giorgio, Melissari, Massimo, Balbi, Tiziana, Quaini, Federico, Cigola, Elena, Sonnenblick, Edmund H, Anversa, Piero
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.08.1994
• Subjects: Biological and medical sciences; Cardiology. Vascular system; Cardiomegaly - pathology; Cell Count; Cell Size; Endomyocardial Fibrosis - pathology; Female; Heart; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Heart Ventricles - pathology; Humans; hypertensive cardiomyopathy; Male; Medical sciences; Middle Aged; Myocardium - pathology; myocyte cellular hypertrophy; Organ Size; replacement fibrosis; ventricular loading; Human; Quantization; Cardiovascular disease; Exploration; Morphometry; Left ventricle; Hypertrophy

Objective: The aim was to measure changes in the numbers and size of ventricular myocytes in human hearts with marked ventricular hypertrophy and no clear signs of cardiac failure, to determine whether myocyte cellular hypertrophy is the only factor involved in the increase in cardiac mass. Methods:...