Characterization of subthalamic nucleus deep brain stimulation evoked resonant neural activity in a large animal model: A pilot study

• Published in: Brain research Vol. 1846; p. 149233
• Main Authors: Hageman, Kristin, Stypulkowski, Paul, Stanslaski, Scott
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2025
• Subjects: Animals; Deep brain stimulation; Deep Brain Stimulation - methods; Evoked Potentials - physiology; Evoked resonant neural activity; Female; Globus Pallidus - physiology; Large animal model; Male; Models, Animal; Neurology; Pilot Projects; Sheep; Subthalamic nucleus; Subthalamic Nucleus - physiology; Large animal model; Subthalamic nucleus; Deep brain stimulation; Evoked resonant neural activity

[Display omitted] •STN DBS in healthy ovine animal model elicited evoked resonant neural activity (ERNA).•ERNA is present in chronically implanted animals for >2 yrs showing contact specificity.•ERNA amplitude is highly dependent on stimulation frequency due to phase interactions.•Frequency depen...