Screening-Level Assays for Potentially Human-Infectious Environmental Legionella spp

• Published in: The journal of microbiology Vol. 49; no. 2; pp. 200 - 207
• Main Authors: Buse, Helen Y., US Environmental Protection Agency, Cincinnati, OH, USA, Brehm, Abby, US Environmental Protection Agency, Cincinnati, OH, USA, Santo Domingo, Jorge W., US Environmental Protection Agency, Cincinnati, OH, USA, Ashbolt, Nicholas J., US Environmental Protection Agency, Cincinnati, OH, USA
• Format: Journal Article
• Language: English
• Published: Heidelberg The Microbiological Society of Korea 01.04.2011; Springer Nature B.V; 한국미생물학회
• Subjects: Acanthamoeba polyphaga; Aerosols; Animals; Bacteriological Techniques - methods; Biofilms; Biomedical and Life Sciences; Cell Line; Disease Models, Animal; Disinfection & disinfectants; Drinking water; Environmental Microbiology; Humans; LEGIONELLA; Legionella - isolation & purification; Legionella - pathogenicity; Legionellosis - microbiology; Legionnaires disease; Life Sciences; MACROFAGOS; MACROPHAGE; MACROPHAGES; Macrophages - microbiology; Mass Screening - methods; Mice; Mice, Inbred A; Microbiology; PATHOGENICITY; Pathogens; PATOGENICIDAD; POUVOIR PATHOGENE; Protozoa; R&D; Research & development; Virulence; 생물학; United States > US; spp; macrophages; virulence; biofilms

In spite of the fact that various Legionella species are isolated from nonclinical water settings, there is no standard method to determine whether environmental legionellae may be infectious to humans. Here we provide a screening-level approach based on an in vivo murine (A/J mouse) model and three...