CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intake

• Published in: Nature metabolism Vol. 5; no. 6; p. 1045
• Main Authors: Vivot, Karl, Meszaros, Gergö, Pangou, Evanthia, Zhang, Zhirong, Qu, Mengdi, Erbs, Eric, Yeghiazaryan, Gagik, Quiñones, Mar, Grandgirard, Erwan, Schneider, Anna, Clauss-Creusot, Etienne, Charlet, Alexandre, Faour, Maya, Martin, Claire, Berditchevski, Fedor, Sumara, Izabela, Luquet, Serge, Kloppenburg, Peter, Nogueiras, Ruben, Ricci, Romeo
• Format: Journal Article
• Language: English
• Published: Germany 01.06.2023
• Subjects: Agouti-Related Protein - genetics; Agouti-Related Protein - metabolism; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 1 - metabolism; Diabetes Mellitus, Type 2 - metabolism; Eating; Ghrelin - metabolism; Male; Mice; Mice, Knockout; Neurons - metabolism; Neuropeptide Y - genetics; Neuropeptide Y - metabolism; Obesity - metabolism

Hypothalamic AgRP/NPY neurons are key players in the control of feeding behaviour. Ghrelin, a major orexigenic hormone, activates AgRP/NPY neurons to stimulate food intake and adiposity. However, cell-autonomous ghrelin-dependent signalling mechanisms in AgRP/NPY neurons remain poorly defined. Here...