A Randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder - Ibrahim, Lobna; Diaz Granados, Nancy; Jolkovsky, Libby; Brutsche, Nancy; Luckenbaugh, David A; Herring, W Joseph; Potter, William Z; Zarate, Jr, Carlos A (Journal of clinical psychopharmacology, 2012)
Keywords: Administration, Oral; Adolescent; Adult; Antidepressive Agents - therapeutic use; Brain-Derived Neurotrophic Factor - blood; Cross-Over Studies; Depressive Disorder, Treatment-Resistant - blood; Depressive Disorder, Treatment-Resistant - drug therapy; Female; Humans; Male; Middle Aged; Pilot Projects; Piperidines - administration & dosage; Piperidines - adverse effects; Piperidines - blood; Piperidines - therapeutic use; Psychiatric Status Rating Scales - statistics & numerical data; Pyrimidines - administration & dosage; Pyrimidines - adverse effects; Pyrimidines - blood; Pyrimidines - therapeutic use; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors