Antibody durability is influenced by interleukin-2 production by undifferentiated memory T helper cells and extensive B cell clonal expansion

• Published in: Cell reports (Cambridge) Vol. 44; no. 7; p. 115934
• Main Authors: Isogawa, Masanori, Shinoda, Masahiro, Kotaki, Ryutaro, Terahara, Kazutaka, Onodera, Taishi, Kabasawa, Kiyomi, Toyama-Kousaka, Mio, Fujisawa, Mizuki, Watanabe, Mitsukaze, Tonouchi, Keisuke, Terooatea, Tommy, Kitano, Ayumi, Adachi, Yu, Moriyama, Saya, Takano, Tomohiro, Fukushi, Shuetsu, Matsumura, Takayuki, Yamashita, Kazuo, Shinkai, Masaharu, Takahashi, Yoshimasa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.07.2025; Elsevier
• Subjects: Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; antibody durability; B-Lymphocytes - immunology; BACH2; CD4-Positive T-Lymphocytes - immunology; Cell Differentiation; COVID-19 - immunology; COVID-19 - prevention & control; CP: Immunology; helper T cells; Humans; Immunologic Memory; interleukin-2; Interleukin-2 - biosynthesis; Interleukin-2 - immunology; Interleukin-2 - metabolism; Interleukin-21; Memory T Cells - immunology; mRNA vaccine; SARS-CoV-2 - immunology; Spike Glycoprotein, Coronavirus - immunology; T-Lymphocytes, Helper-Inducer - immunology; CP: Immunology; interleukin-2; antibody durability; helper T cells; BACH2; mRNA vaccine

SARS-CoV-2-neutralizing antibody titers serve as immune correlates of protection against COVID-19; however, the durability varies among vaccinees. Here, we demonstrate that the durability of vaccine-boosted antibody responses is closely correlated with the pre-booster capacity of spike-reactive CD4+...