Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β2 adrenergic receptors

• Published in: Cellular & molecular biology letters Vol. 29; no. 1; pp. 132 - 23
• Main Authors: Kundu, Dooti, Min, Xiao, Wang, Shujie, Peng, Lulu, Tian, Xinru, Wang, Mengling, Kim, Kyeong-Man
• Format: Journal Article
• Language: English
• Published: Wrocław BioMed Central 28.10.2024; BMC
• Subjects: Adrenergic receptors; Antibodies; Arrestin; b-Adrenergic-receptor kinase; Binding sites; Cell activation; Desensitization; Deubiquitination; Dopamine; Dopamine D2 receptors; Dopamine D3 receptors; Dopamine D4 receptors; EGFR; Epidermal growth factor; Epidermal growth factor receptors; Fluorides; G protein-coupled receptors; GPCR; Growth factor receptors; Kinases; Ligands; Phosphorylation; Proteins; Signal transduction; Transactivation; United States > US

Transactivation of epidermal growth factor receptors (EGFR) provides intricate control over multiple regulatory cellular processes that merge the diversity of G protein-coupled receptors (GPCRs) with the robust signaling capacities of receptor tyrosine kinases. Contrary to the typical assertions, ou...