Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner

• Published in: Experimental gerontology Vol. 119; pp. 61 - 73
• Main Authors: Huang, Dong-Dong, Fan, Sheng-Dong, Chen, Xi-Yi, Yan, Xia-Lin, Zhang, Xian-Zhong, Ma, Bing-Wei, Yu, Ding-Ye, Xiao, Wen-Yu, Zhuang, Cheng-Le, Yu, Zhen
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.05.2019
• Subjects: Aging; Frailty; Mitochondria; Nrf2; Sarcopenia; Skeletal muscle; Aging; Sarcopenia; Frailty; Mitochondria; Nrf2; Skeletal muscle

Mitochondrial dysfunction during aging is a key factor that contributes to sarcopenia. Nuclear factor erythroid 2-related factor 2 (Nrf2) has been increasingly recognized to regulate mitochondrial function. The present study aimed to investigate the role of Nrf2 in the development of frailty and sar...