Transcriptomics Analysis Identifies the Decline in the Alveolar Type II Stem Cell Niche in Aged Human Lungs

• Published in: American journal of respiratory cell and molecular biology Vol. 71; no. 2; pp. 229 - 241
• Main Authors: Liu, Xue, Zhang, Xuexi, Yao, Changfu, Liang, Jiurong, Noble, Paul W., Jiang, Dianhua
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.08.2024
• Subjects: Adult; Aged; Aging; Aging - genetics; Alveolar Epithelial Cells - metabolism; Alveolar Epithelial Cells - pathology; Alveoli; Cell interactions; Cellular Senescence - genetics; Chemokines; Elastin; Female; Gene Expression Profiling; Genetic analysis; Humans; Lung - metabolism; Lung - pathology; Lung cancer; Lung diseases; Macrophages; Male; Mesenchyme; Middle Aged; Original Research; Senescence; Stem Cell Niche; Stem cells; Stem Cells - metabolism; Transcriptome - genetics; Transcriptomics; human lung; macrophage; niche; aging; alveolar type II cell

Aging poses a global public health challenge, which is linked to the rise of age-related lung diseases. The precise understanding of the molecular and genetic changes in the aging lung that elevate the risk of acute and chronic lung diseases remains incomplete. Alveolar type II (AT2) cells are stem...