Anti-apoptotic protein Bcl-2 contributes to the determination of reserve cells during myogenic differentiation of C2C12 cells

• Published in: In vitro cellular & developmental biology. Animal Vol. 60; no. 7; pp. 760 - 770
• Main Authors: Nagata, Yosuke, Tomimori, Jun, Hagiwara, Tomoharu
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2024; Society for In Vitro Biology
• Subjects: Animal Genetics and Genomics; Animals; Apoptosis; Apoptosis - genetics; Bcl-2 protein; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell Differentiation; Cell growth; Cell Line; Cell Proliferation; Cell Survival; Cell viability; Chronic illnesses; Developmental Biology; Duchenne's muscular dystrophy; Dystrophy; Gene expression; Life Sciences; Mice; Muscle Development; Muscle regulatory factor; Muscle, Skeletal - cytology; Muscle, Skeletal - metabolism; Muscles; Muscular dystrophy; Musculoskeletal system; Myoblasts; Myoblasts - cytology; Myoblasts - metabolism; Pattern analysis; pro-apoptotic proteins; Progenitor cells; Proteins; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - metabolism; RNA, Small Interfering - metabolism; Satellite cells; siRNA; Skeletal muscle; Stem Cells; Transfection; Bcl-2; Skeletal muscle regeneration; Muscle satellite cells; Reserve cells; Quiescence

Summary Skeletal muscle's regenerative ability is vital for maintaining muscle function, but chronic diseases like Duchenne muscular dystrophy can deplete this capacity. Muscle satellite cells, quiescent in normal situations, are activated during muscle injury, expressing myogenic regulatory fa...