Cell tension, matrix mechanics, and cancer development

• Published in: Cancer cell Vol. 8; no. 3; pp. 175 - 176
• Main Authors: Huang, Sui, Ingber, Donald E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2005
• Subjects: Cell Shape; Extracellular Matrix - physiology; Humans; Neoplasms - pathology; Neoplasms - physiopathology; Signal Transduction; Stress, Mechanical

Oncologists often diagnose cancer based on a change of tissue stiffness sensed by palpation, yet cancer researchers generally focus on biochemical signaling mechanisms. Tumors are more rigid because they have a stiffer extracellular matrix. A new study shows that this alteration of matrix mechanics...