Hepatic oval cell response to the choline-deficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclo-oxygenase 2 inhibitor

• Published in: Carcinogenesis (New York) Vol. 27; no. 8; pp. 1607 - 1616
• Main Authors: Davies, Richard A., Knight, Belinda, Tian, Yan Wu, Yeoh, George C.T., Olynyk, John K.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.08.2006; Oxford Publishing Limited (England)
• Subjects: Animals; Antimetabolites - administration & dosage; Apoptosis - drug effects; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Cell Proliferation - drug effects; Choline Deficiency; Cyclooxygenase 2 - chemistry; Cyclooxygenase 2 - metabolism; Cyclooxygenase 2 Inhibitors - pharmacology; Diet; Dietary Supplements; Disease Models, Animal; Ethionine - administration & dosage; Liver - drug effects; Liver - injuries; Liver Diseases - prevention & control; Medical sciences; Mice; Mice, Inbred C57BL; Microfilament Proteins; Pesticides, fertilizers and other agrochemicals toxicology; Phosphorylation - drug effects; Protein-Tyrosine Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Pyrazoles - pharmacology; Pyruvate Kinase - metabolism; Stem Cells - metabolism; Sulfonamides - pharmacology; Toxicology; Tumors; Choleretic; Animal model; Prostaglandin-endoperoxide synthase; Digestive system; Enzyme; Hepatoprotector; Liver; Pesticides; Rodentia; Fungicide; Ethionine; Sulfur containing aminoacid; Vertebrata; Mammalia; Mouse; Choline; Inhibitor; Oxidoreductases; Lesion; Supplementation

Oval cell proliferation precedes neoplasia in many rodent models of hepatocellular carcinoma and prevention of this proliferative response can reduce the risk of subsequent carcinoma. This study aimed to determine whether a selective cyclo-oxygenase-2 (COX-2) inhibitor, SC-236, affects (i) the oval...