A novel glycine site-specific N-methyl- d-aspartate receptor antagonist prevents activation of the NMDA/NO/CGMP pathway by ammonia
Intrastriatal administration of ammonium ions (“ammonia”) via a microdialysis probe overactivates N-methyl- d-aspartate (NMDA) receptors, which results in cGMP accumulation in the microdialysates. Co-administration of a potent glycine site-specific NMDA receptor antagonist CGP 78608 ([(1 S)-1-[[(7-b...
Saved in:
| Published in | Brain research Vol. 1015; no. 1; pp. 186 - 188 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Elsevier B.V
23.07.2004
Amsterdam Elsevier New York, NY |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Intrastriatal administration of ammonium ions (“ammonia”) via a microdialysis probe overactivates
N-methyl-
d-aspartate (NMDA) receptors, which results in cGMP accumulation in the microdialysates. Co-administration of a potent glycine site-specific NMDA receptor antagonist CGP 78608 ([(1
S)-1-[[(7-bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]phosphonate) significantly reduced (at 20 nM) or abolished (at 100 nM) ammonia-dependent cGMP synthesis. Since NMDA receptor activation is an important causative factor in ammonia neurotoxicity, the present results suggest the glycine site of the receptor to be a potential valuable target for protective intervention. |
|---|---|
| AbstractList | Intrastriatal administration of ammonium ions ("ammonia") via a microdialysis probe overactivates N-methyl-D-aspartate (NMDA) receptors, which results in cGMP accumulation in the microdialysates. Co-administration of a potent glycine site-specific NMDA receptor antagonist CGP 78608 ([(1S)-1-[[(7-bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]phosphonate) significantly reduced (at 20 nM) or abolished (at 100 nM) ammonia-dependent cGMP synthesis. Since NMDA receptor activation is an important causative factor in ammonia neurotoxicity, the present results suggest the glycine site of the receptor to be a potential valuable target for protective intervention. Intrastriatal administration of ammonium ions (“ammonia”) via a microdialysis probe overactivates N-methyl- d-aspartate (NMDA) receptors, which results in cGMP accumulation in the microdialysates. Co-administration of a potent glycine site-specific NMDA receptor antagonist CGP 78608 ([(1 S)-1-[[(7-bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]phosphonate) significantly reduced (at 20 nM) or abolished (at 100 nM) ammonia-dependent cGMP synthesis. Since NMDA receptor activation is an important causative factor in ammonia neurotoxicity, the present results suggest the glycine site of the receptor to be a potential valuable target for protective intervention. |
| Author | Hilgier, Wojciech Saransaari, Pirjo Oja, Simo S Albrecht, Jan |
| Author_xml | – sequence: 1 givenname: Wojciech surname: Hilgier fullname: Hilgier, Wojciech organization: Department of Neurotoxicology, Medical Research Centre, Polish Academy of Sciences, Pawińskiego St. 5, 02-106, Warsaw, Poland – sequence: 2 givenname: Simo S surname: Oja fullname: Oja, Simo S organization: Brain Research Center, University of Tampere Medical School, Finland – sequence: 3 givenname: Pirjo surname: Saransaari fullname: Saransaari, Pirjo organization: Brain Research Center, University of Tampere Medical School, Finland – sequence: 4 givenname: Jan surname: Albrecht fullname: Albrecht, Jan email: jalb@cmdik.pan.pl organization: Department of Neurotoxicology, Medical Research Centre, Polish Academy of Sciences, Pawińskiego St. 5, 02-106, Warsaw, Poland |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15939407$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15223384$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkE2P0zAQhi20iO0u_IWVL3BL6o_ETm5UBRak3S4HOFtTZ7J1lTjBdoty5ZeTqkVw4zQazfPOjJ4bcuUHj4TccZZzxtVyn28DOB8w5oKxImdlznjxgix4pUWmRMGuyIIxprKqruU1uYlxP7dS1uwVuealEFJWxYL8WlE_HLGjz91knUcaXcIsjmhd6yzdZD2m3dRltMkgjhASJKQBLY5pCBR8gufBu5joGPCIPkUKNrkjJDd4OrQ07ZBuHj-slpun5fr-8SsdIe1-wkS3E4W-n7PwmrxsoYv45lJvyfdPH7-tP2cPT_df1quHzBaiTJlWGotG6KKV3Koa2rqpmkprzQolGlUJmGelsqxsal1bgbq0KJRgUlkoQctb8u68dwzDjwPGZHoXLXYdeBwO0XBdlbyScgbVGbRhiDFga8bgegiT4cyc7Ju9-WPfnOwbVprZ_hy8u1w4bHts_sYuumfg7QWAaKFrA3jr4j9cLeuCnV59f-Zw9nF0GEy0Dr3Fxs3uk2kG979ffgNgMahh |
| CODEN | BRREAP |
| CitedBy_id | crossref_primary_10_1016_j_neuint_2010_11_015 crossref_primary_10_1016_j_neuint_2012_02_021 crossref_primary_10_1016_j_ejphar_2009_04_043 crossref_primary_10_1254_jphs_SC0070062 crossref_primary_10_1016_j_jceh_2018_06_007 crossref_primary_10_1007_s11011_005_7904_6 crossref_primary_10_1016_j_neuint_2007_12_005 crossref_primary_10_1016_j_neuint_2009_01_007 crossref_primary_10_1016_j_neuint_2014_12_004 crossref_primary_10_1016_j_neuint_2005_12_032 crossref_primary_10_1007_s11064_007_9455_1 crossref_primary_10_1007_s11011_013_9472_5 crossref_primary_10_1111_j_1471_4159_2009_06520_x crossref_primary_10_1007_s11011_010_9184_z crossref_primary_10_1007_s11064_016_2014_x crossref_primary_10_1007_s00109_007_0160_y crossref_primary_10_1016_j_brainresbull_2009_08_002 crossref_primary_10_1016_j_nbd_2009_04_004 crossref_primary_10_1016_j_abb_2013_02_002 crossref_primary_10_1007_s11064_016_1966_1 crossref_primary_10_1007_s12640_016_9668_7 crossref_primary_10_1016_j_bcp_2010_07_024 |
| Cites_doi | 10.1097/00008877-199508000-00018 10.1007/BF02532401 10.1016/S0014-2999(98)00112-5 10.1016/S0197-0186(03)00015-9 10.1016/S0960-894X(99)00576-4 10.1016/S0006-8993(03)02777-X 10.1002/hep.510310322 10.1002/hep.510240425 10.1023/A:1014894320421 10.1016/S0014-2999(03)01667-4 10.1097/00004647-199702000-00005 10.1002/hep.510250406 10.1111/j.1527-3458.2003.tb00253.x |
| ContentType | Journal Article |
| Copyright | 2004 Elsevier B.V. 2004 INIST-CNRS |
| Copyright_xml | – notice: 2004 Elsevier B.V. – notice: 2004 INIST-CNRS |
| DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TK |
| DOI | 10.1016/j.brainres.2004.05.014 |
| DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Neurosciences Abstracts |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Neurosciences Abstracts |
| DatabaseTitleList | MEDLINE Neurosciences Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1872-6240 |
| EndPage | 188 |
| ExternalDocumentID | 10_1016_j_brainres_2004_05_014 15223384 15939407 S0006899304007413 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Comparative Study |
| GroupedDBID | --- --K --M -DZ -~X .1- .55 .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 23N 4.4 41~ 457 4G. 53G 5GY 5RE 5VS 6J9 7-5 71M 8P~ 9JM AABNK AACTN AADPK AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXLA AAXUO AAYJJ ABCQJ ABFNM ABFRF ABIVO ABJNI ABLJU ABMAC ABTEW ABXDB ABYKQ ACDAQ ACGFO ACGFS ACIUM ACNCT ACRLP ADBBV ADEZE ADIYS ADMUD AEBSH AEFWE AEKER AENEX AEVXI AFCTW AFKWA AFMIJ AFRHN AFTJW AFXIZ AGHFR AGUBO AGWIK AGYEJ AHHHB AHPSJ AI. AIEXJ AIKHN AITUG AJBFU AJOXV AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMQ HVGLF HZ~ IHE J1W K-O KOM L7B M2V M41 MO0 MOBAO MVM N9A O-L O9- OAUVE OP~ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SES SEW SNS SPCBC SSN SSZ T5K VH1 WUQ X7M XPP Z5R ZGI ~G- 08R AAPBV AAUGY ABPIF ABPTK IQODW AAXKI AKRWK CGR CUY CVF ECM EIF NPM AAYXX AFJKZ CITATION 7TK |
| ID | FETCH-LOGICAL-c425t-767e4d274f31c69af9d8d87770462d682a27456c05d979c2e75ce262036ca5a73 |
| IEDL.DBID | .~1 |
| ISSN | 0006-8993 |
| IngestDate | Fri Oct 25 02:39:34 EDT 2024 Thu Sep 26 17:34:06 EDT 2024 Sat Sep 28 07:41:15 EDT 2024 Sun Oct 22 16:02:32 EDT 2023 Fri Feb 23 02:36:11 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Striatum Ammonia cGMP Microdialysis NMDA receptor Glycine site Rat Rodentia Central nervous system 3',5'-GMP Glutamate receptor Corpus striatum Glycine Encephalon Vertebrata Mammalia Nitric oxide NMDA Antagonist |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c425t-767e4d274f31c69af9d8d87770462d682a27456c05d979c2e75ce262036ca5a73 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| PMID | 15223384 |
| PQID | 17851833 |
| PQPubID | 23462 |
| PageCount | 3 |
| ParticipantIDs | proquest_miscellaneous_17851833 crossref_primary_10_1016_j_brainres_2004_05_014 pubmed_primary_15223384 pascalfrancis_primary_15939407 elsevier_sciencedirect_doi_10_1016_j_brainres_2004_05_014 |
| PublicationCentury | 2000 |
| PublicationDate | 2004-07-23 |
| PublicationDateYYYYMMDD | 2004-07-23 |
| PublicationDate_xml | – month: 07 year: 2004 text: 2004-07-23 day: 23 |
| PublicationDecade | 2000 |
| PublicationPlace | London Amsterdam New York, NY |
| PublicationPlace_xml | – name: Amsterdam – name: London – name: New York, NY – name: Netherlands |
| PublicationTitle | Brain research |
| PublicationTitleAlternate | Brain Res |
| PublicationYear | 2004 |
| Publisher | Elsevier B.V Elsevier |
| Publisher_xml | – name: Elsevier B.V – name: Elsevier |
| References | Anderzhanova, Oja, Saransaari, Albrecht (BIB2) 2003; 977 Hermenegildo, Monfort, Felipo (BIB5) 2000; 31 Vogels, Maas, Daalhuisen, Quack, Chamuleau (BIB11) 1997; 25 Pepicelli, Brescia, Gherzi, Raiteri, Fedele (BIB8) 2004; 46 Ametamey, Kokic, Carrey-Remy, Blauenstein, Willmann, Bischoff, Schmutz, Schubiger, Auberson (BIB1) 2000; 10 Balster, Mansbach, Shelton, Nicholson, Grech, Wiley, Li, Weber (BIB3) 1995; 6 Sanchez-Perez, Montoliu, Felipo (BIB9) 2003; 9 Takaoka, Bart, Pearlstein, Brinkhous, Warner (BIB10) 1997; 17 Hilgier, Anderzhanova, Oja, Saransaari, Albrecht (BIB6) 2003; 468 Zielińska, Law, Albrecht (BIB14) 2003; 43 Michalak, Rose, Butterworth, Butterworth (BIB7) 1996; 24 Wenk, Baker, Stoehr, Hauss-Wegrzyniak, Danysz (BIB12) 1998; 347 Zielińska, Hilgier, Borkowska, Oja, Saransaari, Goryński, Albrecht (BIB13) 2002; 27 Hermenegildo, Marcaida, Montoliu, Grisolia, Miñana, Felipo (BIB4) 1996; 21 Wenk (10.1016/j.brainres.2004.05.014_BIB12) 1998; 347 Michalak (10.1016/j.brainres.2004.05.014_BIB7) 1996; 24 Hilgier (10.1016/j.brainres.2004.05.014_BIB6) 2003; 468 Takaoka (10.1016/j.brainres.2004.05.014_BIB10) 1997; 17 Pepicelli (10.1016/j.brainres.2004.05.014_BIB8) 2004; 46 Hermenegildo (10.1016/j.brainres.2004.05.014_BIB4) 1996; 21 Sanchez-Perez (10.1016/j.brainres.2004.05.014_BIB9) 2003; 9 Zielińska (10.1016/j.brainres.2004.05.014_BIB14) 2003; 43 Ametamey (10.1016/j.brainres.2004.05.014_BIB1) 2000; 10 Anderzhanova (10.1016/j.brainres.2004.05.014_BIB2) 2003; 977 Balster (10.1016/j.brainres.2004.05.014_BIB3) 1995; 6 Hermenegildo (10.1016/j.brainres.2004.05.014_BIB5) 2000; 31 Vogels (10.1016/j.brainres.2004.05.014_BIB11) 1997; 25 Zielińska (10.1016/j.brainres.2004.05.014_BIB13) 2002; 27 |
| References_xml | – volume: 31 start-page: 709 year: 2000 end-page: 715 ident: BIB5 article-title: Activation of publication-title: Hepatology contributor: fullname: Felipo – volume: 43 start-page: 299 year: 2003 end-page: 303 ident: BIB14 article-title: Excitotoxic mechanism of cell swelling in rat cerebral cortical slices treated acutely with ammonia publication-title: Neurochem. Int. contributor: fullname: Albrecht – volume: 46 start-page: 480 year: 2004 end-page: 489 ident: BIB8 article-title: GABAA, but not NMDA, receptors modulate in vivo NO-mediated cGMP synthesis in the rat cerebral cortex publication-title: Neurosci. Lett. contributor: fullname: Fedele – volume: 17 start-page: 161 year: 1997 end-page: 167 ident: BIB10 article-title: Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled publication-title: J. Cereb. Blood Flow Metab. contributor: fullname: Warner – volume: 9 start-page: 263 year: 2003 end-page: 274 ident: BIB9 article-title: Trialkylglycines: a new family of compounds with in vivo neuroprotective activity publication-title: CNS Drug Rev. contributor: fullname: Felipo – volume: 24 start-page: 908 year: 1996 end-page: 913 ident: BIB7 article-title: Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure publication-title: Hepatology contributor: fullname: Butterworth – volume: 977 start-page: 290 year: 2003 end-page: 293 ident: BIB2 article-title: Changes in the striatal extracellular levels of dopamine and dihydroxyphenylacetic acid evoked by ammonia and publication-title: Brain Res. contributor: fullname: Albrecht – volume: 21 start-page: 1237 year: 1996 end-page: 1244 ident: BIB4 article-title: NMDA receptor antagonists prevent acute ammonia toxicity in mice publication-title: Neurochem. Res. contributor: fullname: Felipo – volume: 10 start-page: 75 year: 2000 end-page: 78 ident: BIB1 article-title: Synthesis, radiolabelling and biological characterization of ( publication-title: Bioorg. Med. Chem. Lett. contributor: fullname: Auberson – volume: 27 start-page: 27 year: 2002 end-page: 32 ident: BIB13 article-title: Ammonia-induced extracellular accumulation of taurine in the rat striatum in vivo: role of ionotropic glutamate receptors publication-title: Neurochem. Res. contributor: fullname: Albrecht – volume: 468 start-page: 21 year: 2003 end-page: 25 ident: BIB6 article-title: Taurine reduces ammonia- and publication-title: Eur. J. Pharmacol. contributor: fullname: Albrecht – volume: 25 start-page: 820 year: 1997 end-page: 827 ident: BIB11 article-title: Memantine, a noncompetitive NMDA receptor antagonist improves hyperammonemia-induced encephalopathy and acute hepatic encephalopathy in rats publication-title: Hepatology contributor: fullname: Chamuleau – volume: 6 start-page: 577 year: 1995 end-page: 589 ident: BIB3 article-title: Behavioral pharmacology of two novel substituted quinoxalinedione glutamate antagonists publication-title: Behav. Pharmacol. contributor: fullname: Weber – volume: 347 start-page: 183 year: 1998 end-page: 187 ident: BIB12 article-title: Neuroprotection by novel antagonists at the NMDA receptor channel and glycine publication-title: Eur. J. Pharmacol. contributor: fullname: Danysz – volume: 6 start-page: 577 year: 1995 ident: 10.1016/j.brainres.2004.05.014_BIB3 article-title: Behavioral pharmacology of two novel substituted quinoxalinedione glutamate antagonists publication-title: Behav. Pharmacol. doi: 10.1097/00008877-199508000-00018 contributor: fullname: Balster – volume: 21 start-page: 1237 year: 1996 ident: 10.1016/j.brainres.2004.05.014_BIB4 article-title: NMDA receptor antagonists prevent acute ammonia toxicity in mice publication-title: Neurochem. Res. doi: 10.1007/BF02532401 contributor: fullname: Hermenegildo – volume: 347 start-page: 183 year: 1998 ident: 10.1016/j.brainres.2004.05.014_BIB12 article-title: Neuroprotection by novel antagonists at the NMDA receptor channel and glycineB sites publication-title: Eur. J. Pharmacol. doi: 10.1016/S0014-2999(98)00112-5 contributor: fullname: Wenk – volume: 43 start-page: 299 year: 2003 ident: 10.1016/j.brainres.2004.05.014_BIB14 article-title: Excitotoxic mechanism of cell swelling in rat cerebral cortical slices treated acutely with ammonia publication-title: Neurochem. Int. doi: 10.1016/S0197-0186(03)00015-9 contributor: fullname: Zielińska – volume: 10 start-page: 75 year: 2000 ident: 10.1016/j.brainres.2004.05.014_BIB1 article-title: Synthesis, radiolabelling and biological characterization of (d)-7-iodo-N-(1-phosphonoethyl)-5-aminomethylquinoxaline-2,3-dione, a glycine-binding site antagonist of NMDA receptors publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/S0960-894X(99)00576-4 contributor: fullname: Ametamey – volume: 977 start-page: 290 year: 2003 ident: 10.1016/j.brainres.2004.05.014_BIB2 article-title: Changes in the striatal extracellular levels of dopamine and dihydroxyphenylacetic acid evoked by ammonia and N-methyl-d-aspartate: modulation by taurine publication-title: Brain Res. doi: 10.1016/S0006-8993(03)02777-X contributor: fullname: Anderzhanova – volume: 31 start-page: 709 year: 2000 ident: 10.1016/j.brainres.2004.05.014_BIB5 article-title: Activation of N-methyl-d-aspartate receptors in rat brain in vivo following acute ammonia intoxication: characterization by in vivo brain microdialysis publication-title: Hepatology doi: 10.1002/hep.510310322 contributor: fullname: Hermenegildo – volume: 24 start-page: 908 year: 1996 ident: 10.1016/j.brainres.2004.05.014_BIB7 article-title: Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure publication-title: Hepatology doi: 10.1002/hep.510240425 contributor: fullname: Michalak – volume: 27 start-page: 27 year: 2002 ident: 10.1016/j.brainres.2004.05.014_BIB13 article-title: Ammonia-induced extracellular accumulation of taurine in the rat striatum in vivo: role of ionotropic glutamate receptors publication-title: Neurochem. Res. doi: 10.1023/A:1014894320421 contributor: fullname: Zielińska – volume: 468 start-page: 21 year: 2003 ident: 10.1016/j.brainres.2004.05.014_BIB6 article-title: Taurine reduces ammonia- and N-methyl-d-aspartate-induced accumulation of cyclic GMP and hydroxyl radicals in microdialysates of the rat striatum publication-title: Eur. J. Pharmacol. doi: 10.1016/S0014-2999(03)01667-4 contributor: fullname: Hilgier – volume: 17 start-page: 161 year: 1997 ident: 10.1016/j.brainres.2004.05.014_BIB10 article-title: Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled publication-title: J. Cereb. Blood Flow Metab. doi: 10.1097/00004647-199702000-00005 contributor: fullname: Takaoka – volume: 25 start-page: 820 year: 1997 ident: 10.1016/j.brainres.2004.05.014_BIB11 article-title: Memantine, a noncompetitive NMDA receptor antagonist improves hyperammonemia-induced encephalopathy and acute hepatic encephalopathy in rats publication-title: Hepatology doi: 10.1002/hep.510250406 contributor: fullname: Vogels – volume: 9 start-page: 263 year: 2003 ident: 10.1016/j.brainres.2004.05.014_BIB9 article-title: Trialkylglycines: a new family of compounds with in vivo neuroprotective activity publication-title: CNS Drug Rev. doi: 10.1111/j.1527-3458.2003.tb00253.x contributor: fullname: Sanchez-Perez – volume: 46 start-page: 480 year: 2004 ident: 10.1016/j.brainres.2004.05.014_BIB8 article-title: GABAA, but not NMDA, receptors modulate in vivo NO-mediated cGMP synthesis in the rat cerebral cortex publication-title: Neurosci. Lett. contributor: fullname: Pepicelli |
| SSID | ssj0003390 |
| Score | 1.9281108 |
| Snippet | Intrastriatal administration of ammonium ions (“ammonia”) via a microdialysis probe overactivates
N-methyl-
d-aspartate (NMDA) receptors, which results in cGMP... Intrastriatal administration of ammonium ions ("ammonia") via a microdialysis probe overactivates N-methyl-D-aspartate (NMDA) receptors, which results in cGMP... Intrastriatal administration of ammonium ions ('ammonia') via a microdialysis probe overactivates N-methyl-d-aspartate (NMDA) receptors, which results in cGMP... |
| SourceID | proquest crossref pubmed pascalfrancis elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 186 |
| SubjectTerms | Allosteric Regulation Ammonia Ammonia - toxicity Animals Binding Sites Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors cGMP Corpus Striatum - cytology Corpus Striatum - drug effects Corpus Striatum - metabolism Cyclic GMP - metabolism Fundamental and applied biological sciences. Psychology Glycine - metabolism Glycine site Male Microdialysis Microinjections Neurons - drug effects Neurons - metabolism Neurotoxins - toxicity Nitric Oxide - metabolism NMDA receptor Organophosphonates - pharmacology Quinoxalines - pharmacology Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - classification Receptors, N-Methyl-D-Aspartate - metabolism Striatum Vertebrates: nervous system and sense organs |
| Title | A novel glycine site-specific N-methyl- d-aspartate receptor antagonist prevents activation of the NMDA/NO/CGMP pathway by ammonia |
| URI | https://dx.doi.org/10.1016/j.brainres.2004.05.014 https://www.ncbi.nlm.nih.gov/pubmed/15223384 https://search.proquest.com/docview/17851833 |
| Volume | 1015 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELaqckFCCCiP5bHMAXFzk13HcXKMFsry2KVCVOotsh272mqbROwWtBcO_HJm4kRtDxUHTpESW7E845n5PC_G3pAOsEpPuM48ApQ8M1x7o7m10qupsBPTefAXy3R-knw6lad7bDbkwlBYZS_7g0zvpHX_Jup3M2pXK8rxjVNEC4LYEPUiVfxMUP0hTx_-vgrzECLcsxByptHXsoTPDw21YUBY2-HEUMEzuU1B3Wv1BrfNh34XtxuknWI6esDu9xYlFGHRD9meqx-xg6JGNH2xg7fQxXh2l-cH7E8BdfPTreFsvSOPOpDvmFO2JUUMAUpVh4Rbc6i4RlFDfnoHuD-uRWgOSAR91lCpXWhD5acNUF5EuNWFxgNak7BcvCui5ddo9mFxDNTw-JfegdmBJo5f6cfs5Oj999mc910YuMXzvOUqVS6pELx6MbFprn1eZRVVEaS01irNphq_ydTGsspVbqdOSeuozL1IrZZaiSdsv25q94wB1Q5DCJVLxIiJi6fGS2NwmDSp8rHPRiwatr5sQ7GNcohCOy8HYlHnzKSMZYnEGrF8oFB5g21K1Aj_nDu-QdKrX8qc-sWrEXs90LjEQ0eeFF275nJTThQaqpkQI_Y0kP7aXLS3RJY8_4-FvWB3Q3yQ4lPxku1vf1y6V2j6bM244-0xu1PMvn05pufHz_PlXyJ2BT4 |
| link.rule.ids | 315,783,787,4509,24128,27936,27937,45597,45691 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZKOYCEEFAey6OdA-LmJhvHcXJcLZQFuguHVuotsh272mpJInYL2gsHfjkzcaK2h4oD1yRWrJnxzHyeF2NvyQZYpcdc5x4BSpEbrr3R3FrpVSLs2HQR_Pkim52mn8_k2Q6bDrUwlFbZ6_6g0ztt3T-JempG7XJJNb5xhmhBkBiiXRR32N2U_GMU6sPfV3keQoSLFoLO9Pm1MuGLQ0NzGBDXdkAxtPBMb7NQD1q9Rrr5MPDido-0s0xHj9jD3qWESdj1Y7bj6idsb1IjnP6-hXfQJXl2t-d77M8E6uanW8H5akshdaDgMadyS0oZAlSrDjm34lBxjbqGAvUOkECuRWwOyAV93lCvXWhD66c1UGFEuNaFxgO6k7CYv59Ei6_R9OP8G9DE4196C2YLmkR-qZ-y06MPJ9MZ78cwcIsHesNVplxaIXr1YmyzQvuiyitqI0h1rVWWJxrfyczGsipUYROnpHXU515kVkutxDO2Wze1e8GAmochhiokgsTUxYnx0hj8TJpM-djnIxYNpC_b0G2jHNLQLsqBWTQ6My1jWSKzRqwYOFTekJsSTcI_1-7fYOnVL2VBA-PViB0MPC7x1FEoRdeuuVyXY4Weai7EiD0PrL-2Fh0ukacv_2NjB-ze7GR-XB5_Wnx5xe6HZCHFE_Ga7W5-XLo36AdtzH4n538B-vYFQg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+novel+glycine+site-specific+N-methyl-d-aspartate+receptor+antagonist+prevents+activation+of+the+NMDA%2FNO%2FCGMP+pathway+by+ammonia&rft.jtitle=Brain+research&rft.au=Hilgier%2C+W&rft.au=Oja%2C+S+S&rft.au=Saransaari%2C+P&rft.au=Albrecht%2C+J&rft.date=2004-07-23&rft.issn=0006-8993&rft.volume=1015&rft.issue=1-2&rft.spage=186&rft.epage=188&rft_id=info:doi/10.1016%2Fj.brainres.2004.05.014&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0006-8993&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0006-8993&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0006-8993&client=summon |