Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotype

• Published in: Experimental gerontology Vol. 82; pp. 39 - 49
• Main Authors: Malaquin, Nicolas, Martinez, Aurélie, Rodier, Francis
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.09.2016
• Subjects: Aging - genetics; Cellular Senescence - genetics; Cytokines - metabolism; DNA Damage; Epigenesis, Genetic; Epigenetics; Humans; Intracellular signalling pathways; Neoplasms - metabolism; NF-kappa B - genetics; Nuclear factor kappa B; Phenotype; Senescence-messaging secretome; Signal Transduction; Signalling cascade; Epigenetics; Senescence-messaging secretome; Signal transduction; Signalling cascade; Intracellular signalling pathways; Nuclear factor kappa B

Cellular senescence is historically associated with cancer suppression and aging. Recently, the reach of the senescence genetic program has been extended to include the ability of senescent cells to actively participate in tissue remodelling during many physiological processes, including placental b...