Impact of demography and population dynamics on the genetic architecture of human longevity

• Published in: Aging (Albany, NY.) Vol. 10; no. 8; pp. 1947 - 1963
• Main Authors: Giuliani, Cristina, Sazzini, Marco, Pirazzini, Chiara, Bacalini, Maria Giulia, Marasco, Elena, Ruscone, Guido Alberto Gnecchi, Fang, Fang, Sarno, Stefania, Gentilini, Davide, Di Blasio, Anna Maria, Crocco, Paolina, Passarino, Giuseppe, Mari, Daniela, Monti, Daniela, Nacmias, Benedetta, Sorbi, Sandro, Salvarani, Carlo, Catanoso, Mariagrazia, Pettener, Davide, Luiselli, Donata, Ukraintseva, Svetlana, Yashin, Anatoliy, Franceschi, Claudio, Garagnani, Paolo
• Format: Journal Article
• Language: English
• Published: United States Impact Journals 08.08.2018
• Subjects: Research Paper; human genetics; longevity; population dynamics; centenarians
• ISSN: 1945-4589; 1945-4589
• DOI: 10.18632/aging.101515

The study of the genetics of longevity has been mainly addressed by GWASs that considered subjects from different populations to reach higher statistical power. The "price to pay" is that population-specific evolutionary histories and trade-offs were neglected in the investigation of gene-...