DIFFERENT ALLELE-DISTRIBUTION OF MTHFR 677 C → T AND MTHFR −393 C → A IN PATIENTS CLASSIFIED ACCORDING TO SUBTYPES OF LESCH'S TYPOLOGY

• Published in: Alcohol and alcoholism (Oxford) Vol. 41; no. 4; pp. 364 - 367
• Main Authors: BÖNSCH, DOMINIKUS, BAYERLEIN, KRISTINA, REULBACH, UDO, FISZER, ROLAND, HILLEMACHER, THOMAS, SPERLING, WOLFGANG, KORNHUBER, JOHANNES, BLEICH, STEFAN
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.2006; Oxford Publishing Limited (England)
• Subjects: Adult; Alanine - genetics; Alcohol Drinking - psychology; Alcoholism - classification; Alcoholism - genetics; Alcoholism - psychology; Alcoholism and acute alcohol poisoning; Alleles; Amino Acid Substitution - genetics; Biological and medical sciences; Cytosine - metabolism; DNA Mutational Analysis; Gene Frequency - genetics; Genetic Predisposition to Disease - genetics; Genetic Variation - genetics; Genotype; Homocysteine - blood; Humans; Male; Medical sciences; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Middle Aged; Motivation; Nucleotide Mapping; Thymidine - genetics; Toxicology; Valine - genetics; Human; Methylenetetrahydrofolate reductase (NADPH); Gene frequency; Enzyme; Oxidoreductases; Typology; Subtype

Aims: The typology by Lesch distinguishes between four subtypes: type 1 (model of allergy), type 2 (model of anxiety or conflict), type 3 (alcohol as an antidepressant), and type 4 (alcohol as adaptation). Taking into account that alcohol dependence is associated with elevated homocysteine levels, t...