The toxic effects of heavy metals on rat bone marrow in vitro erythropoiesis: protective role of hemin and zinc

• Published in: Environmental research Vol. 35; no. 1; p. 97
• Main Authors: Lutton, J D, Ibraham, N G, Friedland, M, Levere, R D
• Format: Journal Article
• Language: English
• Published: Netherlands 01.10.1984
• Subjects: Animals; Bone Marrow - drug effects; Cadmium - toxicity; Erythropoiesis - drug effects; Female; Gold - toxicity; Heme - analogs & derivatives; Hemin - pharmacology; In Vitro Techniques; Lead - toxicity; Rats; Rats, Inbred Strains; Trace Elements - toxicity; Zinc - pharmacology

The effects of gold (Au), lead (Pb), and cadmium (Cd) on rat bone marrow in vitro erythropoiesis (CFUE) were studied. Au was found to be significantly toxic to CFUE growth at concentrations as low as 10(-9) M whereas Pb and Cd displayed toxicity at 10(-7) M. Addition of Pb plus Cd in combination had...