Integrin-linked kinase control dental pulp stem cell senescence via the mTOR signaling pathway

• Published in: Stem cells (Dayton, Ohio) Vol. 42; no. 10; pp. 861 - 873
• Main Authors: Chen, Lu, Wang, Xiping, Tian, Sha, Zhou, Linxi, Wang, Li, Liu, Xiaohan, Yang, Zihan, Fu, Guiqiang, Liu, Xingguang, Ding, Chen, Zou, Duohong
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 09.10.2024
• Subjects: Adolescent; Adult; Animals; Cell Differentiation - drug effects; Cell Proliferation - drug effects; Cellular Senescence - drug effects; Child; Dental Pulp - cytology; Dental Pulp - metabolism; Humans; Male; Osteogenesis - drug effects; Osteogenesis - genetics; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Rats; Signal Transduction; Stem Cells - cytology; Stem Cells - metabolism; TOR Serine-Threonine Kinases - metabolism; Young Adult; ILK; proteomic; cellular senescence; osteogenesis; HDPSCs

Abstract Human dental pulp stem cells (HDPSCs) showed an age-dependent decline in proliferation and differentiation capacity. Decline in proliferation and differentiation capacity affects the dental stromal tissue homeostasis and impairs the regenerative capability of HDPSCs. However, which age-corr...