Biomanufacturing organized collagen-based microfibers as a Tissue ENgineered Device (TEND) for tendon regeneration

• Published in: Biomedical materials (Bristol) Vol. 16; no. 2; p. 025025
• Main Authors: Maghdouri-White, Yas, Sori, Nardos, Petrova, Stella, Wriggers, Hilary, Kemper, Nathan, Dasgupta, Amrita, Coughenour, Kelly, Polk, Seth, Thayer, Nick, Mario, Rodriguez Dvm, Simon Dpm, Bill, Bulysheva, Anna, Bonner, Kevin, Arnoczky Dvm, Steven, Adams Md, Samuel, Francis, Michael P
• Format: Journal Article
• Language: English
• Published: England 01.03.2021
• Subjects: Achilles Tendon - pathology; Achilles Tendon - surgery; Adsorption; Animals; Bone Marrow Cells - cytology; Cell Differentiation; Cell Proliferation; Cell Survival; Collagen Type I - metabolism; Connective Tissue; Female; Humans; Intercellular Signaling Peptides and Proteins - metabolism; Male; Platelet-Rich Plasma - metabolism; Polyesters - chemistry; Porosity; Rabbits; Rats; Regeneration; Spectroscopy, Fourier Transform Infrared; Stem Cells - cytology; Stress, Mechanical; Tendon Injuries - surgery; Tendons - cytology; Thermogravimetry; Tissue Engineering - instrumentation; Tissue Engineering - methods; Up-Regulation

Approximately 800, 000 surgical repairs are performed annually in the U.S. for debilitating injuries to ligaments and tendons of the foot, ankle, knee, wrist, elbow and shoulder, presenting a significant healthcare burden. To overcome current treatment shortcomings and advance the treatment of tendo...